ID M7NWX2_PNEMU Unreviewed; 1468 AA.
AC M7NWX2;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=VPS10 domain-containing protein {ECO:0000259|SMART:SM00602};
GN ORFNames=PNEG_00099 {ECO:0000313|EMBL:EMR11661.1};
OS Pneumocystis murina (strain B123) (Mouse pneumocystis pneumonia agent)
OS (Pneumocystis carinii f. sp. muris).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Pneumocystomycetes; Pneumocystaceae; Pneumocystis.
OX NCBI_TaxID=1069680 {ECO:0000313|EMBL:EMR11661.1, ECO:0000313|Proteomes:UP000011958};
RN [1] {ECO:0000313|Proteomes:UP000011958}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B123 {ECO:0000313|Proteomes:UP000011958};
RX PubMed=26899007; DOI=10.1038/ncomms10740;
RA Ma L., Chen Z., Huang D.W., Kutty G., Ishihara M., Wang H., Abouelleil A.,
RA Bishop L., Davey E., Deng R., Deng X., Fan L., Fantoni G., Fitzgerald M.,
RA Gogineni E., Goldberg J.M., Handley G., Hu X., Huber C., Jiao X., Jones K.,
RA Levin J.Z., Liu Y., Macdonald P., Melnikov A., Raley C., Sassi M.,
RA Sherman B.T., Song X., Sykes S., Tran B., Walsh L., Xia Y., Yang J.,
RA Young S., Zeng Q., Zheng X., Stephens R., Nusbaum C., Birren B.W.,
RA Azadi P., Lempicki R.A., Cuomo C.A., Kovacs J.A.;
RT "Genome analysis of three Pneumocystis species reveals adaptation
RT mechanisms to life exclusively in mammalian hosts.";
RL Nat. Commun. 7:10740-10740(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMR11661.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AFWA02000005; EMR11661.1; -; Genomic_DNA.
DR RefSeq; XP_007871956.1; XM_007873765.1.
DR STRING; 1069680.M7NWX2; -.
DR GeneID; 19893797; -.
DR VEuPathDB; FungiDB:PNEG_00099; -.
DR eggNOG; KOG3511; Eukaryota.
DR HOGENOM; CLU_000700_0_0_1; -.
DR OMA; ATMSEFI; -.
DR OrthoDB; 5840at2759; -.
DR Proteomes; UP000011958; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007034; P:vacuolar transport; IEA:UniProt.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.10.70.80; -; 2.
DR Gene3D; 3.30.60.270; -; 2.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR PANTHER; PTHR12106:SF27; VPS10 HOMOLOG 1-RELATED; 1.
DR Pfam; PF15902; Sortilin-Vps10; 2.
DR Pfam; PF15901; Sortilin_C; 2.
DR SMART; SM00602; VPS10; 2.
DR SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000011958};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1359..1383
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 54..684
FT /note="VPS10"
FT /evidence="ECO:0000259|SMART:SM00602"
FT DOMAIN 720..1347
FT /note="VPS10"
FT /evidence="ECO:0000259|SMART:SM00602"
SQ SEQUENCE 1468 AA; 169957 MW; 244ACAE5BCAC1321 CRC64;
MAHLNSLNIS KIFCIFSFLF FGVLGAKNYH ITVTSFKHSL FSFFYFDNSK VILAHDILDK
VIWKSDNEGT SWTKIKSIPK NKAKMLILHP FSDRMAFVLG EDKTHYYTDD QGLTWKSFST
ENPFSEETAP LKFNSANPNY IIFIGSECVD SARINCKFMA YYTKDAFNTN PKLLKENIQS
CMFAKSSKEF SNCSDELVLC VYMQSNIYAS GIYLMKSEDW FSTYTHINFD EKPLVSLEGI
GTVQTFIIAV VRSHNTELEM YVSKDGNTWN KAKFPYYHQK KLKENSYTIM ESKPYSLQVD
ILTSEYPFYG GISFKSDISG IYYTPSLEHT NRNDMGYVDF EDIRFIDGAI FANVIENWKE
LENNGDFDKK IQSKISYDNG NTWNSIKPPI NSDCNIFDSK ICSLHLHSIT DRYRFDKTFS
SYAPGILIGI GSVGSYLKPF HECNLYISED AGKTWSLSLE GTHIYECSDH ANIIAAIPDQ
KTRNFYYSFD RGRNWQSIDL KHNIRPLALI VIPNSKTGKF LLIATEFNEN DIDHSINAIS
IDIGEAFTKQ CILDKNDLEK SDLEKWYSHT ENESNCSMGR KQYFWRRKIG RKCFIKENYS
ELQVIEENCP CSNNDYECDY NFMEYDNKCL EQVPQEIPPD ACKKPDDVFW APSGYRKIPG
NICDSKRGVI KDKKIEVSCK TNTHLDKIRI TLTDFKGELV NYYYLKKNED DSNDKNDADE
TILVLTNQME LHVSHDQGNQ WNQILADENI LFMYQNVYTS EQVYFFGMNK KAWVTKNRCL
TIEKIQLPIY SHIEYKPEFH PDNKDWIIYT GCKDNKIMQE CETESYYSLD GGNSWNLLIS
NTRSCSWIKT KDFDADKNLI YCEVYIFDSE KSSDNPVKLV YSTDFFNTYN VLFDSITNYA
RFKEFIILGK YNSQLKTLEP YISLDGLNFT IANFPSHYSG QIYTILDSST KSIFVHVTKD
DYKSFKWGSI LKSNSNGTNF VKSLDFVDRN SDGFIDFERF KGLEGIIISN IVINPDDIVK
GSSKRVKSLI TYNDGSEWSY LTPPKEDSKG NKYCTGKLEK CSLNLHGVIE RIDLHGTFSS
ITIPGLDFAI GNVGEYLDNY LNSNTFMTLD GGVTWKEIQK GPYLWKFGDQ GSIILLVRDK
DYTDHFLYSL DMGSTWKTVY FPEKESILIY DITTVYSDTS RKFLLFSIRS NNGNKWTAIH
IDFTMLTDRK CKLNEDSLDK SDFNTWSFKY PNSENSCLFG TIKTYYRKKS ERHCFIGKSN
IKHYISKNCT CQPQDYECDY NYERASDGSC QLIQGLKPLD HLEECKKHNL LEYNKPTGYR
RIPLTTCQGG KELDKDSTPI PCPSKEKKFI KLGKGLHGFE LFCIIISPFI IIIFGSYCMW
ILYKDRFLGQ IRLGEDERPS GLIQYPIILL DKITVLFSAI RTITNYIITR IISLFSGYRF
NTRNSFFRNN YSALLSDSPE LLYDDFES
//
