ID M7P386_PNEMU Unreviewed; 679 AA.
AC M7P386;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Glycogen [starch] synthase {ECO:0000256|RuleBase:RU363104};
DE EC=2.4.1.11 {ECO:0000256|RuleBase:RU363104};
GN ORFNames=PNEG_03440 {ECO:0000313|EMBL:EMR08275.1};
OS Pneumocystis murina (strain B123) (Mouse pneumocystis pneumonia agent)
OS (Pneumocystis carinii f. sp. muris).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Pneumocystomycetes; Pneumocystaceae; Pneumocystis.
OX NCBI_TaxID=1069680 {ECO:0000313|EMBL:EMR08275.1, ECO:0000313|Proteomes:UP000011958};
RN [1] {ECO:0000313|Proteomes:UP000011958}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B123 {ECO:0000313|Proteomes:UP000011958};
RX PubMed=26899007; DOI=10.1038/ncomms10740;
RA Ma L., Chen Z., Huang D.W., Kutty G., Ishihara M., Wang H., Abouelleil A.,
RA Bishop L., Davey E., Deng R., Deng X., Fan L., Fantoni G., Fitzgerald M.,
RA Gogineni E., Goldberg J.M., Handley G., Hu X., Huber C., Jiao X., Jones K.,
RA Levin J.Z., Liu Y., Macdonald P., Melnikov A., Raley C., Sassi M.,
RA Sherman B.T., Song X., Sykes S., Tran B., Walsh L., Xia Y., Yang J.,
RA Young S., Zeng Q., Zheng X., Stephens R., Nusbaum C., Birren B.W.,
RA Azadi P., Lempicki R.A., Cuomo C.A., Kovacs J.A.;
RT "Genome analysis of three Pneumocystis species reveals adaptation
RT mechanisms to life exclusively in mammalian hosts.";
RL Nat. Commun. 7:10740-10740(2016).
CC -!- FUNCTION: Transfers the glycosyl residue from UDP-Glc to the non-
CC reducing end of alpha-1,4-glucan. {ECO:0000256|RuleBase:RU363104}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[(1->4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->4)-
CC alpha-D-glucosyl](n+1) + H(+) + UDP; Xref=Rhea:RHEA:18549, Rhea:RHEA-
CC COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC ChEBI:CHEBI:58223, ChEBI:CHEBI:58885; EC=2.4.1.11;
CC Evidence={ECO:0000256|ARBA:ARBA00043769};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18550;
CC Evidence={ECO:0000256|ARBA:ARBA00043769};
CC -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004964, ECO:0000256|RuleBase:RU363104}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 3 family.
CC {ECO:0000256|ARBA:ARBA00010686, ECO:0000256|RuleBase:RU363104}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMR08275.1}.
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DR EMBL; AFWA02000017; EMR08275.1; -; Genomic_DNA.
DR RefSeq; XP_007875527.1; XM_007877336.1.
DR AlphaFoldDB; M7P386; -.
DR STRING; 1069680.M7P386; -.
DR GeneID; 19897127; -.
DR VEuPathDB; FungiDB:PNEG_03440; -.
DR eggNOG; KOG3742; Eukaryota.
DR HOGENOM; CLU_015910_1_0_1; -.
DR OMA; RDVRNHI; -.
DR OrthoDB; 9432at2759; -.
DR UniPathway; UPA00164; -.
DR Proteomes; UP000011958; Unassembled WGS sequence.
DR GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 6.10.260.10; -; 1.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR InterPro; IPR008631; Glycogen_synth.
DR PANTHER; PTHR10176:SF3; GLYCOGEN [STARCH] SYNTHASE; 1.
DR PANTHER; PTHR10176; GLYCOGEN SYNTHASE; 1.
DR Pfam; PF05693; Glycogen_syn; 1.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 2.
PE 3: Inferred from homology;
KW Glycogen biosynthesis {ECO:0000256|ARBA:ARBA00023056,
KW ECO:0000256|RuleBase:RU363104};
KW Glycosyltransferase {ECO:0000256|RuleBase:RU363104};
KW Reference proteome {ECO:0000313|Proteomes:UP000011958};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU363104}.
SQ SEQUENCE 679 AA; 78234 MW; EAD42F27419841F9 CRC64;
MDSEKLRDVK NHILFEVSVE VCNRVGGIYS VLKSKAPVTS LEYSYDRYIA IGKFTQSAIN
FEVEQLSTED QPILHKTLQY MKNRGISYTY GRWLIDGAPR VLLFDIGNAF HWLNEWKGDL
WNTTGIPSPP DDSETNDAIA FGYIVAWFLG EFISHEYERA VVVHFHEWLA GVALPLCRKR
RLDLTTIFTT HATILGRYLC ADNADFYNNL QYFDVDYEAG KRGIYHRYCI ERAAAHSADV
FTTVSHITAY ESEHLLKRKP DGVLPNGLNV VKFAAVHEFQ NLHATFKQKI NEFVRGHFYG
HNDFDLDNTL YFFISGRYEY RNKGVDLYIE SLARLNERMK ASDSKMTVIA FIIMPAATHS
YTVEALKGQA VMKSLQNTIE HIQKGIGQRI FEKCCRHSKD FDEKFIDTSS LLTDQDKILL
KRRVFALKRS TLPPIVTHNM ADNNDPILTQ IRRVQLFNSD DDRVKIIFHP EFLNSNNPIL
PLDYDDFVRG CHLGVFPSYY EPWGYTSAEA VVMGVPSVTT NISGFGCYME NIIENPSDYG
VYIVDRRMKS VDESINQLTN IMYNFTTKTR RQRINQRNRC ERLSDFLDWK IMGLEYIKAR
QLALRRAYPN SFDTDDLIDK NIDLSLGTLI KVPHPLSAPT SPKCRNGFLS IHNLDDIQNI
QCLNTSEYAT NKHSDNDDE
//
