ID M7P406_PNEMU Unreviewed; 524 AA.
AC M7P406;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=FYVE-type domain-containing protein {ECO:0000259|PROSITE:PS50178};
GN ORFNames=PNEG_03071 {ECO:0000313|EMBL:EMR08595.1};
OS Pneumocystis murina (strain B123) (Mouse pneumocystis pneumonia agent)
OS (Pneumocystis carinii f. sp. muris).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Pneumocystomycetes; Pneumocystaceae; Pneumocystis.
OX NCBI_TaxID=1069680 {ECO:0000313|EMBL:EMR08595.1, ECO:0000313|Proteomes:UP000011958};
RN [1] {ECO:0000313|Proteomes:UP000011958}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B123 {ECO:0000313|Proteomes:UP000011958};
RX PubMed=26899007; DOI=10.1038/ncomms10740;
RA Ma L., Chen Z., Huang D.W., Kutty G., Ishihara M., Wang H., Abouelleil A.,
RA Bishop L., Davey E., Deng R., Deng X., Fan L., Fantoni G., Fitzgerald M.,
RA Gogineni E., Goldberg J.M., Handley G., Hu X., Huber C., Jiao X., Jones K.,
RA Levin J.Z., Liu Y., Macdonald P., Melnikov A., Raley C., Sassi M.,
RA Sherman B.T., Song X., Sykes S., Tran B., Walsh L., Xia Y., Yang J.,
RA Young S., Zeng Q., Zheng X., Stephens R., Nusbaum C., Birren B.W.,
RA Azadi P., Lempicki R.A., Cuomo C.A., Kovacs J.A.;
RT "Genome analysis of three Pneumocystis species reveals adaptation
RT mechanisms to life exclusively in mammalian hosts.";
RL Nat. Commun. 7:10740-10740(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMR08595.1}.
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DR EMBL; AFWA02000015; EMR08595.1; -; Genomic_DNA.
DR RefSeq; XP_007875127.1; XM_007876936.1.
DR AlphaFoldDB; M7P406; -.
DR STRING; 1069680.M7P406; -.
DR GeneID; 19896758; -.
DR VEuPathDB; FungiDB:PNEG_03071; -.
DR eggNOG; KOG1842; Eukaryota.
DR HOGENOM; CLU_026440_1_0_1; -.
DR OMA; QASNFLH; -.
DR OrthoDB; 1441111at2759; -.
DR Proteomes; UP000011958; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15761; FYVE1_Vac1p_like; 1.
DR CDD; cd15737; FYVE2_Vac1p_like; 1.
DR Gene3D; 4.10.860.20; Rabenosyn, Rab binding domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR021565; Rbsn_Rab-bd.
DR InterPro; IPR036531; Rbsn_Rab-bd_sf.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR13510; FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED; 1.
DR PANTHER; PTHR13510:SF44; RABENOSYN-5; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF11464; Rbsn; 1.
DR SMART; SM00064; FYVE; 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 2.
DR SUPFAM; SSF140125; Rabenosyn-5 Rab-binding domain-like; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000011958};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 239..318
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
SQ SEQUENCE 524 AA; 61997 MW; CFE8A4F874902E15 CRC64;
MIRSKYQGVL YCPVCNKLSK DLYELNVHLD ENHFDVTEKQ KETVKSWFKK KVDEAKQLAS
IVVTQHYLHK EEFELNENQV ETEVTKEHWQ IEENVSCFFE SCCKSLISKG ERINCRKCGK
LFCNAHTTYQ IKLSQDAQHD PYHGVWSRVC KYCYEERKGY MDTNGPVIDY FSEFKHFRTQ
AVDKINLHAN RLEKRISKLF ELVLDSKNVP VTNSFYKLIN SFKSRKKALE QTIVSWEDDF
SVTHCPICKH SFNYTNKKHH CRLCGKIICA NLKTECSSMV QLNMKSRCLN TFNSEIVHKN
STNASIYSDL SIRICKNCRR IVFSRKEFSD SLSKPHQLDI FYKELSTLRY KIETLLPNFK
SQLDELRKAF NANQKRIDEV ALIREKILDT FFQYDKLSKN ISQLTTKSLA IKNLQIEIHS
EAKRFLQKHM LSLQFVPNLK KKGNNNTNKM MHFPKLNEKK YLELHILEEQ RHQVQNWIKD
ASKRRKYDEV GVLLDNMNML SLEIEKIRAQ VHEFSPSFEH KTYS
//
