ID M7P594_PNEMU Unreviewed; 274 AA.
AC M7P594;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=VWFA domain-containing protein {ECO:0000259|PROSITE:PS50234};
GN ORFNames=PNEG_02822 {ECO:0000313|EMBL:EMR09050.1};
OS Pneumocystis murina (strain B123) (Mouse pneumocystis pneumonia agent)
OS (Pneumocystis carinii f. sp. muris).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Pneumocystomycetes; Pneumocystaceae; Pneumocystis.
OX NCBI_TaxID=1069680 {ECO:0000313|EMBL:EMR09050.1, ECO:0000313|Proteomes:UP000011958};
RN [1] {ECO:0000313|Proteomes:UP000011958}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B123 {ECO:0000313|Proteomes:UP000011958};
RX PubMed=26899007; DOI=10.1038/ncomms10740;
RA Ma L., Chen Z., Huang D.W., Kutty G., Ishihara M., Wang H., Abouelleil A.,
RA Bishop L., Davey E., Deng R., Deng X., Fan L., Fantoni G., Fitzgerald M.,
RA Gogineni E., Goldberg J.M., Handley G., Hu X., Huber C., Jiao X., Jones K.,
RA Levin J.Z., Liu Y., Macdonald P., Melnikov A., Raley C., Sassi M.,
RA Sherman B.T., Song X., Sykes S., Tran B., Walsh L., Xia Y., Yang J.,
RA Young S., Zeng Q., Zheng X., Stephens R., Nusbaum C., Birren B.W.,
RA Azadi P., Lempicki R.A., Cuomo C.A., Kovacs J.A.;
RT "Genome analysis of three Pneumocystis species reveals adaptation
RT mechanisms to life exclusively in mammalian hosts.";
RL Nat. Commun. 7:10740-10740(2016).
CC -!- SIMILARITY: Belongs to the proteasome subunit S5A family.
CC {ECO:0000256|ARBA:ARBA00005574}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMR09050.1}.
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DR EMBL; AFWA02000007; EMR09050.1; -; Genomic_DNA.
DR RefSeq; XP_007874856.1; XM_007876665.1.
DR AlphaFoldDB; M7P594; -.
DR STRING; 1069680.M7P594; -.
DR GeneID; 19896511; -.
DR VEuPathDB; FungiDB:PNEG_02822; -.
DR eggNOG; KOG2884; Eukaryota.
DR HOGENOM; CLU_033293_1_0_1; -.
DR OMA; QMSMQDQ; -.
DR OrthoDB; 169547at2759; -.
DR Proteomes; UP000011958; Unassembled WGS sequence.
DR GO; GO:0000502; C:proteasome complex; IEA:UniProtKB-KW.
DR CDD; cd01452; VWA_26S_proteasome_subunit; 1.
DR Gene3D; 1.10.287.3990; -; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR003903; UIM_dom.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10223; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4; 1.
DR PANTHER; PTHR10223:SF0; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4; 1.
DR Pfam; PF13519; VWA_2; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50330; UIM; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Proteasome {ECO:0000256|ARBA:ARBA00022942};
KW Reference proteome {ECO:0000313|Proteomes:UP000011958}.
FT DOMAIN 5..189
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 234..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 274 AA; 30597 MW; 0FADA10B90415572 CRC64;
MTLEATMIVM DNSEFARNGD YLPTRFGSQK DAINLIFSAK MRAHPENMIG LMSMGGKGPE
ILVTLTQDYG KFLAAMHESK IGGNSNICTS IQVAHLALKH RPEKRQRQRI IVFVGSPVTE
DEKTLVKLAK KMKKNNVSVD FVYFGEICEE NTAKLNAFIE AINSDNNSHL TTIPPGPRLL
SDQLLYSPII ATDRASMHST SNIQGGFPSE HFDFGVDPNL DPELALALQM SLQEEQARQE
VQEGRSRENN TELSNHTIQK DSTQENTEKM DVEK
//
