ID M7P6T7_PNEMU Unreviewed; 1933 AA.
AC M7P6T7;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 55.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EMR09600.1};
GN ORFNames=PNEG_02184 {ECO:0000313|EMBL:EMR09600.1};
OS Pneumocystis murina (strain B123) (Mouse pneumocystis pneumonia agent)
OS (Pneumocystis carinii f. sp. muris).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Pneumocystomycetes; Pneumocystaceae; Pneumocystis.
OX NCBI_TaxID=1069680 {ECO:0000313|EMBL:EMR09600.1, ECO:0000313|Proteomes:UP000011958};
RN [1] {ECO:0000313|Proteomes:UP000011958}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B123 {ECO:0000313|Proteomes:UP000011958};
RX PubMed=26899007; DOI=10.1038/ncomms10740;
RA Ma L., Chen Z., Huang D.W., Kutty G., Ishihara M., Wang H., Abouelleil A.,
RA Bishop L., Davey E., Deng R., Deng X., Fan L., Fantoni G., Fitzgerald M.,
RA Gogineni E., Goldberg J.M., Handley G., Hu X., Huber C., Jiao X., Jones K.,
RA Levin J.Z., Liu Y., Macdonald P., Melnikov A., Raley C., Sassi M.,
RA Sherman B.T., Song X., Sykes S., Tran B., Walsh L., Xia Y., Yang J.,
RA Young S., Zeng Q., Zheng X., Stephens R., Nusbaum C., Birren B.W.,
RA Azadi P., Lempicki R.A., Cuomo C.A., Kovacs J.A.;
RT "Genome analysis of three Pneumocystis species reveals adaptation
RT mechanisms to life exclusively in mammalian hosts.";
RL Nat. Commun. 7:10740-10740(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMR09600.1}.
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DR EMBL; AFWA02000012; EMR09600.1; -; Genomic_DNA.
DR RefSeq; XP_007874167.1; XM_007875976.1.
DR STRING; 1069680.M7P6T7; -.
DR GeneID; 19895877; -.
DR VEuPathDB; FungiDB:PNEG_02184; -.
DR eggNOG; KOG0952; Eukaryota.
DR HOGENOM; CLU_000335_2_0_1; -.
DR OMA; MCSATEF; -.
DR OrthoDB; 57056at2759; -.
DR Proteomes; UP000011958; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0010467; P:gene expression; IEA:UniProt.
DR GO; GO:0090304; P:nucleic acid metabolic process; IEA:UniProt.
DR CDD; cd18795; SF2_C_Ski2; 2.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR Gene3D; 1.10.3380.10; Sec63 N-terminal domain-like domain; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004179; Sec63-dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR47961; DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED; 1.
DR PANTHER; PTHR47961:SF13; SEC63 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00270; DEAD; 2.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF02889; Sec63; 2.
DR PIRSF; PIRSF039073; BRR2; 1.
DR SMART; SM00382; AAA; 2.
DR SMART; SM00487; DEXDc; 2.
DR SMART; SM00490; HELICc; 2.
DR SMART; SM00973; Sec63; 2.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 2.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 2.
DR PROSITE; PS51194; HELICASE_CTER; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000011958}.
FT DOMAIN 283..476
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 512..722
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 1141..1316
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 1349..1556
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 1933 AA; 222816 MW; 0989FC36D148D5B3 CRC64;
MNSTNAFSNS LKEMKNYLNK IGEYNENYRN NLYFIKIKNF YGNDFKKYLS NLYLIIDSFK
KESKNDINFQ EHTINSIKKP LDLNKVKDYC ESIEKKNICL YIEPLFVTIK NIILSTNNEF
ELQNELLNIL GYNNLDFIIL IIQNIQNLKN EVLHINNQAN SWNNVIFSSR KDYRNASESN
ITRYDQDNLF FKDQSYENLE SYPNIYGISN SRSSLSIFGT KFSLPLCSTR DIYPLYEEIT
VQPPNKAQKI DNKIIFIKEM NNLCSKSFQE YQTLNYIQSL IYPIAYETNE NMLICAPTGA
GKTDIAILAI MRVISQFSDP SPYKEPKSKN FKINKSEFKV IYISPMKALA SEIVKKIKGR
LSWLNIQVQE LTGDIQLTKS EIISTQILVT TPEKWDIMTR KNVGDIGLTQ KVKLMIFDEI
HMLHDERGTV IETLIARTQR YIESSQTMIR IIGLSATLPN YIDVARFLGV NCYHGLFYFS
DQFRSVPLEQ HFLGVKGKPG SKISSTNMNL VTYEKVIQLV KNNHQVMVFV HTRKETAKTA
KTLLNLALND GYQDIFNPSN HTHYNFFKKD ISKSKNKEMK ELLEKGFGIH NAGMLRSDRN
IVEKYFSIGI IRILCCTATL AWGVNLPAYA VIIKGTQIYE PQKGIFVDLG ILDVLQIFGR
AGRPQYEDRG IGYIITSNDK LAHYVSSVTQ QHPIESKFME KLTDNLNAEI SLGSVTNVEE
AISWLSYTYF YIRMKKNPLI YGLTQEDIRD DPQIYKRRKE LIISAAKKLY ETQMIIFNKK
SGFLSPKDLG RIASNYYISR ENIENFNLTL KSNITEEEVF HILSKSSEFS QMKYRENENE
ELKQLLEKYC HYKIKETIDS TPGKVNILLQ SYISKALIED SALISDSNYI ATNASRICRA
LFEIALSRNW ESALTILSVC KSIERQIWSY EHPLSQFNLP TKILQKLEMH NNIGNMEDLK
RLSKTELGML IHHIRLGGII SNYINKFPLI KIDAKIFPIT KKILRIQLNI QPNFIWDNTI
HNLVELFWIW VEDSDSTEIL HSLHLLLSKK KKEETLDFVI LLPDIIPSQI LIWGISDKWL
KAETMTPISL NNIVFPDDSS SITELLDLQP LPISALNNHV LEEIYSKKFI FFNAIQTQIF
HTLYHTNINV LIGAPTGSGK TIAAELSLWW AFKTKPSSKI IYIAPMKALV RERVKDWTTR
FANPLKKKII ELTGDTSPDS KEIYEANIII TTPEKWDGIS RNWKKRKYVQ EICLIIIDEI
HLLGDDRGPI LEIIVSRMNY IATQNKSHIR IIGLSTAITN ALDLADWLSI KEEGLYNFRH
SVRPIPLKIY IDGFSGHKYC QRMASMNKSV FSAILDHSPD KPVLIFVSSR RQTRLTSQDL
ITYCGLEENP KRFLHMSDHK LNMILTQVKD ESLKNALNFG IGLHHAGLTE NDRKLSEELF
INNKIQILIA TSTLAWGINT PTHLVIVKGT EFFDAKTQGY KDMNLTDVLQ MLGRAGRPQF
DTAGIAKIFV QDTKKSFYKH FLHEGFPVES SLHKVLTDHI SAEIVNETIS SEQDAIDYLT
WTYFFRRIHK NPTYYGLSDS SQNSINTYLS KIINTSINEL IESNCIYRDE NGTLKATVFG
SIASYYYISH KTIRNLLSKI KIEINFKSCL KLLSEASEFD ELSVRHNEDI INKEISQKLP
FKSEEMALPL WDPHVKTFLL IQAHLKHFDL PIIDYITDTI SILDQSVRIL QAYIDISTEL
GYLETCLEFI SLLQCIKHAR WPELSELSIL PGVNHENAMN LQQISQTKLE FLPKKSKNDL
EKLGLLLKVP KEKMIEFINV AKTIPIVTIE ISQKEKSFLN ITLIKDSKPY HPNYILYSPK
FPKPQKEGWY ILCTSHTSNR IHVLKRLTMS KHTHGILNTN IIIPQTIYGE IVNIIVISDT
FCIKKVHSIT LMS
//
