ID M7S7C8_EUTLA Unreviewed; 1381 AA.
AC M7S7C8;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Putative multidrug resistance protein {ECO:0000313|EMBL:EMR61999.1};
GN ORFNames=UCREL1_11097 {ECO:0000313|EMBL:EMR61999.1};
OS Eutypa lata (strain UCR-EL1) (Grapevine dieback disease fungus) (Eutypa
OS armeniacae).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Xylariomycetidae; Xylariales; Diatrypaceae; Eutypa.
OX NCBI_TaxID=1287681 {ECO:0000313|EMBL:EMR61999.1, ECO:0000313|Proteomes:UP000012174};
RN [1] {ECO:0000313|Proteomes:UP000012174}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UCR-EL1 {ECO:0000313|Proteomes:UP000012174};
RX PubMed=23723393; DOI=10.1128/genomeA.00228-13;
RA Blanco-Ulate B., Rolshausen P.E., Cantu D.;
RT "Draft genome sequence of the grapevine dieback fungus Eutypa lata UCR-
RT EL1.";
RL Genome Announc. 1:E0022813-E0022813(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; KB707516; EMR61999.1; -; Genomic_DNA.
DR RefSeq; XP_007798934.1; XM_007800743.1.
DR STRING; 1287681.M7S7C8; -.
DR KEGG; ela:UCREL1_11097; -.
DR eggNOG; KOG0055; Eukaryota.
DR eggNOG; KOG0058; Eukaryota.
DR HOGENOM; CLU_000604_17_2_1; -.
DR OMA; TFWACLT; -.
DR OrthoDB; 1693178at2759; -.
DR Proteomes; UP000012174; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd18577; ABC_6TM_Pgp_ABCB1_D1_like; 1.
DR Gene3D; 1.20.1560.10; ABC transporter type 1, transmembrane domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039421; Type_1_exporter.
DR PANTHER; PTHR24221; ATP-BINDING CASSETTE SUB-FAMILY B; 1.
DR PANTHER; PTHR24221:SF644; OS07G0464600 PROTEIN; 1.
DR Pfam; PF00664; ABC_membrane; 3.
DR Pfam; PF00005; ABC_tran; 3.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF90123; ABC transporter transmembrane region; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
DR PROSITE; PS50929; ABC_TM1F; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000012174};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..48
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 68..96
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 147..167
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 173..191
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 263..281
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 293..313
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 643..665
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 776..795
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 886..907
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 24..315
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 353..593
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 609..965
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 1014..1381
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 702..724
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 987..1006
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1069..1149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1282..1326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1069..1121
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1285..1301
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1311..1326
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1381 AA; 148317 MW; 72C06038B192A770 CRC64;
MDETKLAFKH LFAFSTWRHC GILALGLTSA LIVSGLKTAL AIILGKVFVA ITGFGSGKVS
GQETFDMISF WCMVIGIAGI AGWLFNFTFM FAWITFGEQQ ARRIRTKTFS ALLKKDMAWF
DCQENGVASL LVGIQSQTRD VQMATSIALG SLSMDVATAF GNLVVAFCFS PKLTLILMGT
VPVSLLILKV ISRNFKHAIQ EQKEELSLAA KHTTAAIASV NLVKVFNGID YETSEYAQSL
GRTMKHYLVQ ARISACQHGY TKLWIEGMFV IGFLYGIVLV NEGVSPGDVL TTFYAALAAL
QAVEAFLPMY LLLVKGMSAG QELGRIVEEG VQRSNSSPRR LGIHKPHTFA GDIEIQSVTF
AYPSNPHSNV LKKASLSFPA GELSFVVGKS GSGKSTLGNL LLKLYEFSSG YIYIDGESLQ
TFDDTWVRNN ITVVQQTSVL FDDAFFMNVA LGHPSNPSKV PVEDVVAACD FAMLQSTVSN
LPHGLATRIG PHGHDLSGGQ KQRVALARAR LRNTPVLILD EVTSDLDPLT RNEIMEKIRR
WRRGSTTIII THDVAQIRNG DRVYVMDDGC VVQQGLREHL AADHDDPFAR LVALSPTPAR
KTRADEGWLT DACVPTFSIV FANLLAALYQ PDADARLASG RRWSLYLLLV AIVGSLATAA
GHYLLDRAGQ AWVDALRLRA FGGVLRQPLA WFSTRSHHSH YQHDHDHHHS PISRSPLPTQ
EHAHSGTLYC NSRFDSNSHS HYHPATRTPN CIVQASLLDR PADEVRQLVS KFGPPLLIAT
LVAASSIGWA LTLSWRLTLV GLASASCFAS AAGAHATAAQ KAAARSDVAA AGTGAVACGA
LAPLSRLKVV RALVLERFFI RRYEGSARGT FKVGVKGAVE TAALFAVWQA AGWFMMAVAF
WYAGVLLRDF GVSDLGYHDD DRRGEGPAAN TTMITAGSVL QVVNLLVLGL SASSNMLHSV
PGVAAAKAAA AQLLYYAELK VDGGEQKGFD GGDGNHGGDG DTTSNTLIVN PLPIRMNGLS
FRYPSNPTVK VLRDITLSIE AGTSTAIVGP SGCGKSTLIS LLLGLYMPDQ STSSSSSSSS
LLPSPRNRNE NDSNTTPTPT PTTSNSNSNS SASSSRPLKT TFYPITPRPR PRPRRQRRPH
PSPPLTFANI SSHNIDLPSL RAQQSYVPQA PILFPCSIGS NILYGLPSSS PLRTARNLVR
AARAAGIHDY VCSLPEGYRT KVGDGGAVAL SGGQAQRVCI ARALARRPRL LVLDEPTGAL
DRGGGGGVAR FLRELVNGGG GISEIGDEGD DDNDGGDGGD GDADSEPYCA LDGYSQSNSD
GGRSMTTTMG AAPAVVVVTH DRELMRAADR IVVMDKGRIV EVGGYRELIA KRGRFAELVR
D
//
