ID M7SEY5_EUTLA Unreviewed; 1332 AA.
AC M7SEY5;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Putative leptomycin b resistance protein pmd1 protein {ECO:0000313|EMBL:EMR62773.1};
GN ORFNames=UCREL1_10284 {ECO:0000313|EMBL:EMR62773.1};
OS Eutypa lata (strain UCR-EL1) (Grapevine dieback disease fungus) (Eutypa
OS armeniacae).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Xylariomycetidae; Xylariales; Diatrypaceae; Eutypa.
OX NCBI_TaxID=1287681 {ECO:0000313|EMBL:EMR62773.1, ECO:0000313|Proteomes:UP000012174};
RN [1] {ECO:0000313|Proteomes:UP000012174}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UCR-EL1 {ECO:0000313|Proteomes:UP000012174};
RX PubMed=23723393; DOI=10.1128/genomeA.00228-13;
RA Blanco-Ulate B., Rolshausen P.E., Cantu D.;
RT "Draft genome sequence of the grapevine dieback fungus Eutypa lata UCR-
RT EL1.";
RL Genome Announc. 1:E0022813-E0022813(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCB family.
CC Multidrug resistance exporter (TC 3.A.1.201) subfamily.
CC {ECO:0000256|ARBA:ARBA00007577}.
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DR EMBL; KB707373; EMR62773.1; -; Genomic_DNA.
DR RefSeq; XP_007798126.1; XM_007799935.1.
DR KEGG; ela:UCREL1_10284; -.
DR eggNOG; KOG0055; Eukaryota.
DR HOGENOM; CLU_000604_17_2_1; -.
DR OMA; GFGQEEQ; -.
DR OrthoDB; 1067095at2759; -.
DR Proteomes; UP000012174; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd18577; ABC_6TM_Pgp_ABCB1_D1_like; 1.
DR CDD; cd18578; ABC_6TM_Pgp_ABCB1_D2_like; 1.
DR CDD; cd03249; ABC_MTABC3_MDL1_MDL2; 2.
DR Gene3D; 1.20.1560.10; ABC transporter type 1, transmembrane domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039421; Type_1_exporter.
DR PANTHER; PTHR24221; ATP-BINDING CASSETTE SUB-FAMILY B; 1.
DR PANTHER; PTHR24221:SF503; LP14331P; 1.
DR Pfam; PF00664; ABC_membrane; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF90123; ABC transporter transmembrane region; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50929; ABC_TM1F; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000012174};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 92..116
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 143..167
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 219..240
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 246..266
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 322..341
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 353..374
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 759..782
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 809..831
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 877..903
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 909..929
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 991..1011
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1023..1047
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 96..386
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 421..666
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 761..1052
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 1087..1325
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..33
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1332 AA; 145421 MW; D2BF18E95CD553F2 CRC64;
MAEFSSEKPG RAIGEGTSPP VSSHSSTDDT RIATGNLEKA DSKVLQVTDQ SSDDPYAHLP
EHEAVILKRQ VITPEVKAGV ATLYRYSTRS DLFIMAISAV CAIAGGAALP LMTVIFGNLQ
GTFEDYFKGQ TAYDDFMDTM TGLVLYFIYL AIGEFVTIYV ATVGFIYTGE HVSGKIREHY
LASCMSQNIG FFDKLGAGEV TTRITADTNL IQEGISEKVG LTLTAVATFV SAFVIGFVFY
WKLTLILTSV VFALLLVMGT GSRFIIGFNK DSIQAYALGG TVAEEVISSI RNSVAFGTQE
RLAKQYDVHL IRAEHFGFRV KATIACMVAG MMLVLYLNYG LSFWMGSKYL VDGVIPLSTV
LIIMMSIMVG AFNLGNVAPN IQAFGTALAA AAKIFNTIDR QSPLDPTVDE GGKLEKVEGN
IRLEHIKHIY PSRPEVVVMK DVTLDIPAGK TTALVGASGS GKSTIVGLVE RFYDPVAGSV
YLDGHDISTL NLRWLRQQIS LVSQEPTLFG TTIYENIRHG LIGTQFEDAS EEKQRELVYE
AAKEANAHDF VSALPEGYET NVGQRGFLLS GGQKQRIAIA RAVVSDPKIL LLDEATSALD
TKSEGVVQAA LEVAAAGRTT ITIAHRLSTI RDAHNIVVMT EGSIVEQGTH DELLEKRGAY
YKLVSAQNIA AVDELTAAEQ EALDAGDDEI VRQASHNKGE AGYIEDPDDN IRAKLNRTNT
QGSASSKALQ SRKAEEEQKY GLWTLIKLIA AFNKSEWKLM LWGLGWSIIC GGGNPTGALF
FAKQIMTLSV PLNDATAGTI KHDSDFWSAM YLMLAFVMFI SQIAQGVAFA YCSERLIHRV
RDRAFRTMLR QDVSFFDRDE NTAGALTSFL STETTHIAGL SGVTLGTILM VVSTLVSSLV
LALAIGWKLA LVCISTVPVL LACGFFRFWM LAHFQRRSKN AYEQSATYAS EAISAIRTVA
SLTREEDVMV QYRESLAAQL RSSLISIAKS SLLYAASQSF LFLAFALGFW YGGTLLAKYE
YDMFQFFVCF MAVIFGAQSA GTVFSFAPDM GKAHQAAAEL KTLFDRKPVV DTWSNDGTPL
EGVEGTIEFR DVHFRYPTRP EQPVLRGLNL TVRPGQYVAL VGASGCGKST TIALLERFYD
PLVGGVYIDG KEISSLNVND YRSYLALVSQ EPTLYQGTIK ENILLGSSSE TVTDEAIDFA
CKESNIYDFI MSLPDGFNTV VGTKGALLSG GQKQRIAIAR ALIRDPKILL LDEATSALDS
ESEHVVQAAL DKAAKGRTTI AVAHRLSTIQ HADAIYVFDQ GRIVEEGTHS ELMRRNGRYA
ELVNLQSLEK RR
//
