ID M7SLU1_EUTLA Unreviewed; 1256 AA.
AC M7SLU1;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Putative polyketide synthase protein {ECO:0000313|EMBL:EMR65132.1};
GN ORFNames=UCREL1_7897 {ECO:0000313|EMBL:EMR65132.1};
OS Eutypa lata (strain UCR-EL1) (Grapevine dieback disease fungus) (Eutypa
OS armeniacae).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Xylariomycetidae; Xylariales; Diatrypaceae; Eutypa.
OX NCBI_TaxID=1287681 {ECO:0000313|EMBL:EMR65132.1, ECO:0000313|Proteomes:UP000012174};
RN [1] {ECO:0000313|Proteomes:UP000012174}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UCR-EL1 {ECO:0000313|Proteomes:UP000012174};
RX PubMed=23723393; DOI=10.1128/genomeA.00228-13;
RA Blanco-Ulate B., Rolshausen P.E., Cantu D.;
RT "Draft genome sequence of the grapevine dieback fungus Eutypa lata UCR-
RT EL1.";
RL Genome Announc. 1:E0022813-E0022813(2013).
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DR EMBL; KB706935; EMR65132.1; -; Genomic_DNA.
DR RefSeq; XP_007795776.1; XM_007797585.1.
DR AlphaFoldDB; M7SLU1; -.
DR STRING; 1287681.M7SLU1; -.
DR KEGG; ela:UCREL1_7897; -.
DR eggNOG; KOG1202; Eukaryota.
DR HOGENOM; CLU_000022_31_8_1; -.
DR OrthoDB; 2479255at2759; -.
DR Proteomes; UP000012174; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd05195; enoyl_red; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR43775:SF29; ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED; 1.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR Pfam; PF13602; ADH_zinc_N_2; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF08242; Methyltransf_12; 1.
DR Pfam; PF00550; PP-binding; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000012174};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1173..1251
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 1256 AA; 137825 MW; 2BED2FBC70D9A954 CRC64;
MRKVACHAIR ALSDVDLDSP NFPSYLSRFA ASLKQYEGQE NESISSWGEI QALLEECEAV
NPIYRLFTEF GRNLRSTLRG GTDTLELLYA SDAAETFYGS VFNDLCDARF EAFLDLASHQ
NPGLRIVEVG AGTGGLTRNV LGALRAFEQR AGSSRFAEYT YTDVSPVFFE AAQAKFTEFT
NRLVFKKLDL ERDPREEGFE LGAYDIVIAG SVLHATARLA LTMANVRALL RPGGYLVNVE
ITAPDSAWAN VGFGSLPGWW LSTEPWRQHG PLVTEQTWQA LAQEAGFSGI DLCLRINGDV
SLMVSTAVEQ GNKNSVALDS YAGQFQYQLI LLVDPGKGAQ LTLASHISKQ WRNVQIVHFD
RVHECTWADT GIVLSLLEVG IPRLAKLGEH DFGALKLLMQ RTQKMLWVTA PSIDDGAETE
ALPQYGLAEG LMRVIRSEEP TKHIVTLAVE SFGSRDLEVV WAQKNCAGYV MQVIKSCFED
TPSSPELEFV VREGHLTIGR LVYRKDLDED RRARIQPQMR DEPWMSGPAL TLEVGVPGML
DTLRFVDDAQ YAQKDLRSGE VEIETKAWPI SFRDVFIALG RLGQEELGFE CAGIVTRVGS
AVKFRPGDRV CMVRPGCMRT YLRAPASAVF KIPDSLPFHD AVAAVNPGMT AYHALINIAR
LQEGEKVLIH SAAGSTGQMA IWIAKRVGAE IFATVGFDKK KQLLVDTFEV SPDHIFYSRN
TSFAQGIMRI TNGCGVDVVL NSLSGDKLEA SWECIAPYGR FVEIGKMDIG ANASLPMAHF
AKNVSFCAID LHHIAQTNVR LTGQLVQAVM DLIALGEAAC PTPLHVYPAT QVEKAFRYMQ
SGRNTGRIII DISHDYIVPK FVVMRSIWRF DPNASYLVAG GLGGLGRAII RWMASKGAKT
LIIPSRSGIS SQAASKVVSQ LQEMGVKIVA PRCDVGSEIG LARLLQDYAS GGMPPIKGCI
NAAMVLQDAV FEGMTYAQWK GTIISKVNSS WNLHQQLPRH MDFFILLSSL SGIYGSLAQA
NYAAGCTFQD ALTRYRTAIG MGKTSVSLDL GWMRDAGIVS EREDYRRNRS NARDMNYVDV
ADLITLLDVY CDPALPPPRG CSRQSSQLLV GAVTPVDIHE QGRPLAPFES RPLFAGFAVT
ATTARRKTAA AQQPQENKEH PTVLFQKAES AEARTSIVVA ALVNKLARAL GVDADNINVQ
RPLSDYGVDS LMAVELRNWV RCDFRAAVAV FEIMDGGAPI TAIGALVTER TEEKLS
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