ID M7T5I1_EUTLA Unreviewed; 156 AA.
AC M7T5I1;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Multiprotein-bridging factor 1 {ECO:0000256|ARBA:ARBA00014317};
GN ORFNames=UCREL1_7953 {ECO:0000313|EMBL:EMR65076.1};
OS Eutypa lata (strain UCR-EL1) (Grapevine dieback disease fungus) (Eutypa
OS armeniacae).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Xylariomycetidae; Xylariales; Diatrypaceae; Eutypa.
OX NCBI_TaxID=1287681 {ECO:0000313|EMBL:EMR65076.1, ECO:0000313|Proteomes:UP000012174};
RN [1] {ECO:0000313|Proteomes:UP000012174}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UCR-EL1 {ECO:0000313|Proteomes:UP000012174};
RX PubMed=23723393; DOI=10.1128/genomeA.00228-13;
RA Blanco-Ulate B., Rolshausen P.E., Cantu D.;
RT "Draft genome sequence of the grapevine dieback fungus Eutypa lata UCR-
RT EL1.";
RL Genome Announc. 1:E0022813-E0022813(2013).
CC -!- FUNCTION: Transcriptional coactivator that stimulates GCN4-dependent
CC transcriptional activity by bridging the DNA-binding region of GCN4 and
CC TBP (SPT15), thereby recruiting TBP to GCN4-bound promoters. Involved
CC in induction of the ribosome quality control (RQC) pathway; a pathway
CC that degrades nascent peptide chains during problematic translation.
CC Required to prevent stalled ribosomes from frameshifting.
CC {ECO:0000256|ARBA:ARBA00035107}.
CC -!- SIMILARITY: Belongs to the MBF1 family.
CC {ECO:0000256|ARBA:ARBA00009802}.
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DR EMBL; KB706946; EMR65076.1; -; Genomic_DNA.
DR RefSeq; XP_007795830.1; XM_007797639.1.
DR AlphaFoldDB; M7T5I1; -.
DR STRING; 1287681.M7T5I1; -.
DR KEGG; ela:UCREL1_7953; -.
DR eggNOG; KOG3398; Eukaryota.
DR HOGENOM; CLU_112609_0_0_1; -.
DR OMA; NKAHQGT; -.
DR OrthoDB; 120438at2759; -.
DR Proteomes; UP000012174; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR CDD; cd00093; HTH_XRE; 1.
DR Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 1.
DR InterPro; IPR001387; Cro/C1-type_HTH.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR InterPro; IPR013729; MBF1_N.
DR PANTHER; PTHR10245:SF15; ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1; 1.
DR PANTHER; PTHR10245; ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1 MULTIPROTEIN BRIDGING FACTOR 1; 1.
DR Pfam; PF01381; HTH_3; 1.
DR Pfam; PF08523; MBF1; 1.
DR SMART; SM00530; HTH_XRE; 1.
DR SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 1.
DR PROSITE; PS50943; HTH_CROC1; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000012174};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 87..147
FT /note="HTH cro/C1-type"
FT /evidence="ECO:0000259|PROSITE:PS50943"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 156 AA; 16762 MW; 5C0C5551F5409DB2 CRC64;
MDDWNSVTKI GSKARGGASQ RETVVRSSSA LNAAKRTGAA IATDKKYATG NAAKGSASGI
GQFHTKVDRS DEIIKPKTVG LAVGNAIKEA RQRCEPTMKQ DELAKKCNTT AAIVQQMEQG
RAPPDQKVLA AMERILNIKL RGKEDEIGKP RFAPKK
//
