ID M7TBW8_EUTLA Unreviewed; 477 AA.
AC M7TBW8;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=ATP-dependent DNA helicase {ECO:0000256|RuleBase:RU363044};
DE EC=3.6.4.12 {ECO:0000256|RuleBase:RU363044};
GN ORFNames=UCREL1_8894 {ECO:0000313|EMBL:EMR64140.1};
OS Eutypa lata (strain UCR-EL1) (Grapevine dieback disease fungus) (Eutypa
OS armeniacae).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Xylariomycetidae; Xylariales; Diatrypaceae; Eutypa.
OX NCBI_TaxID=1287681 {ECO:0000313|EMBL:EMR64140.1, ECO:0000313|Proteomes:UP000012174};
RN [1] {ECO:0000313|Proteomes:UP000012174}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UCR-EL1 {ECO:0000313|Proteomes:UP000012174};
RX PubMed=23723393; DOI=10.1128/genomeA.00228-13;
RA Blanco-Ulate B., Rolshausen P.E., Cantu D.;
RT "Draft genome sequence of the grapevine dieback fungus Eutypa lata UCR-
RT EL1.";
RL Genome Announc. 1:E0022813-E0022813(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|RuleBase:RU363044};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|RuleBase:RU363044};
CC -!- SIMILARITY: Belongs to the helicase family.
CC {ECO:0000256|RuleBase:RU363044}.
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DR EMBL; KB707118; EMR64140.1; -; Genomic_DNA.
DR RefSeq; XP_007796759.1; XM_007798568.1.
DR AlphaFoldDB; M7TBW8; -.
DR STRING; 1287681.M7TBW8; -.
DR KEGG; ela:UCREL1_8894; -.
DR eggNOG; KOG0987; Eukaryota.
DR HOGENOM; CLU_001613_7_3_1; -.
DR OMA; CIKTCKP; -.
DR OrthoDB; 5474774at2759; -.
DR Proteomes; UP000012174; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR CDD; cd18809; SF1_C_RecD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR010285; DNA_helicase_pif1-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR049163; Pif1-like_2B_dom.
DR PANTHER; PTHR47642; ATP-DEPENDENT DNA HELICASE; 1.
DR PANTHER; PTHR47642:SF5; ATP-DEPENDENT DNA HELICASE; 1.
DR Pfam; PF05970; PIF1; 1.
DR Pfam; PF21530; Pif1_2B_dom; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU363044};
KW DNA damage {ECO:0000256|RuleBase:RU363044};
KW DNA recombination {ECO:0000256|RuleBase:RU363044};
KW DNA repair {ECO:0000256|RuleBase:RU363044};
KW Helicase {ECO:0000256|RuleBase:RU363044, ECO:0000313|EMBL:EMR64140.1};
KW Hydrolase {ECO:0000256|RuleBase:RU363044};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU363044};
KW Reference proteome {ECO:0000313|Proteomes:UP000012174}.
FT DOMAIN 276..308
FT /note="DNA helicase Pif1-like 2B"
FT /evidence="ECO:0000259|Pfam:PF21530"
SQ SEQUENCE 477 AA; 53812 MW; AADE599ED8887D23 CRC64;
MGKTVRIAAP TGRAALQVNG TTTWSFAGWT PDHHKRTLDE LCAGAHGRFV WKRLTETDVL
ILDEISMVEN LHFERLNAVM KEARNNKKAF GGVQLIVTGD FCQLPPVKPF QHCIQCGHEL
TAGSSDSGFT FTCSRHGAYF ERDKWAFRAR AWEECNFVHV QLTTIHRQSD EAFIRILQKC
RIGEELASSE VDLLMDHECM VHHATKLFAT RDEVNKVNRI EFEKLKGLKH TYWCLDNFFW
HQDRHPHLQW KSVRKAKGPQ SQGPLRALED HRFSECVELK KGMLVVLLVN LDLASGLCNG
SQGIICGFER NDPKKLPKAK TLKEDPINRI FGDRAPIKEQ QIKLFIEDPG VRYKTWPVVR
FHNGQVRTLY ADCSIAELGD SRPYSLLART QIPLAPAWAM TIHKSQSLTL DRVIVNLSKA
FEEGQVYVAL SRATGLKGLK IEGDSAGLLA GLGGNKEVQE FLRGKFGGVN ARSSITQ
//
