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Database: UniProt
Entry: M7TJJ6_BOTF1
LinkDB: M7TJJ6_BOTF1
Original site: M7TJJ6_BOTF1 
ID   M7TJJ6_BOTF1            Unreviewed;       482 AA.
AC   M7TJJ6;
DT   29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2013, sequence version 1.
DT   24-JAN-2024, entry version 37.
DE   RecName: Full=Vacuolar calcium ion transporter {ECO:0000256|RuleBase:RU365028};
GN   ORFNames=BcDW1_10117 {ECO:0000313|EMBL:EMR81289.1};
OS   Botryotinia fuckeliana (strain BcDW1) (Noble rot fungus) (Botrytis
OS   cinerea).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Helotiales; Sclerotiniaceae; Botrytis.
OX   NCBI_TaxID=1290391 {ECO:0000313|EMBL:EMR81289.1, ECO:0000313|Proteomes:UP000012045};
RN   [1] {ECO:0000313|Proteomes:UP000012045}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BcDW1 {ECO:0000313|Proteomes:UP000012045};
RX   PubMed=23704180; DOI=10.1128/genomea.00252-13;
RA   Blanco-Ulate B., Allen G., Powell A.L., Cantu D.;
RT   "Draft genome sequence of Botrytis cinerea BcDW1, inoculum for noble rot of
RT   grape berries.";
RL   Genome Announc. 1:E0025213-E0025213(2013).
CC   -!- FUNCTION: Has a role in promoting intracellular calcium ion
CC       sequestration via the exchange of calcium ions for hydrogen ions across
CC       the vacuolar membrane. Involved also in manganese ion homeostasis via
CC       its uptake into the vacuole. {ECO:0000256|RuleBase:RU365028}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Vacuole membrane
CC       {ECO:0000256|RuleBase:RU365028}.
CC   -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC       family. {ECO:0000256|ARBA:ARBA00008170, ECO:0000256|RuleBase:RU365028}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|RuleBase:RU365028}.
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DR   EMBL; KB708083; EMR81289.1; -; Genomic_DNA.
DR   AlphaFoldDB; M7TJJ6; -.
DR   STRING; 1290391.M7TJJ6; -.
DR   HOGENOM; CLU_008721_1_1_1; -.
DR   Proteomes; UP000012045; Unassembled WGS sequence.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015369; F:calcium:proton antiporter activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.20.1420.30; NCX, central ion-binding region; 2.
DR   InterPro; IPR004713; CaH_exchang.
DR   InterPro; IPR004798; CAX-like.
DR   InterPro; IPR004837; NaCa_Exmemb.
DR   InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR   NCBIfam; TIGR00378; cax; 1.
DR   PANTHER; PTHR31503; VACUOLAR CALCIUM ION TRANSPORTER; 1.
DR   PANTHER; PTHR31503:SF14; VACUOLAR CALCIUM ION TRANSPORTER; 1.
DR   Pfam; PF01699; Na_Ca_ex; 2.
PE   3: Inferred from homology;
KW   Antiport {ECO:0000256|RuleBase:RU365028};
KW   Calcium {ECO:0000256|RuleBase:RU365028};
KW   Calcium transport {ECO:0000256|RuleBase:RU365028};
KW   Ion transport {ECO:0000256|RuleBase:RU365028};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU365028};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU365028};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU365028}; Transport {ECO:0000256|RuleBase:RU365028};
KW   Vacuole {ECO:0000256|RuleBase:RU365028}.
FT   TRANSMEM        130..149
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365028"
FT   TRANSMEM        161..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365028"
FT   TRANSMEM        190..213
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365028"
FT   TRANSMEM        234..251
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365028"
FT   TRANSMEM        271..289
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365028"
FT   TRANSMEM        395..417
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365028"
FT   TRANSMEM        423..444
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365028"
FT   TRANSMEM        451..471
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365028"
FT   DOMAIN          129..291
FT                   /note="Sodium/calcium exchanger membrane region"
FT                   /evidence="ECO:0000259|Pfam:PF01699"
FT   DOMAIN          327..469
FT                   /note="Sodium/calcium exchanger membrane region"
FT                   /evidence="ECO:0000259|Pfam:PF01699"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   482 AA;  53024 MW;  C30E3A7282A59AF7 CRC64;
     MASTSALPPP NGSRNSGGLR PPLKHSIQIS FSNLPDEVLI ARHKARAESG SPQSTEEDRL
     IPGFEVNHLG FRVTTGIAPE GESGRRGLSP IKCIQLCWKS SSSASQAVNF LWPIVPVAIV
     ITYARPEWHT VIFILNYLSM IPSANLIGFA GQELSRKLDK VFGILMETTL GSVVEIVMFM
     VLLARQQFQV MQAAIMGSIL ATQLLCLGMC FFVGGLTHDE QEFDEEISEV GSDLLLQAGL
     GLIVPAAFNM AVKSANSDYD PFVLADSVLH ISRMTSILLM ISYALYVYFQ MRSHQSIYDA
     IFEADEHKQE DYEEDLLKEK LTFTECVVAL IVAISMVTFT AIRLVESIEF IVDEDGISDS
     FVGLILVPLV EKFAEHLTAI DEAHDNSMNL ALSHVLGATI QTALFNAPLV VIIGWIVNIP
     MDLNFDLFII VVLILSILVV GNFLKDCRSN YLEGALCVLV YINIAVAAFY YPNPPKVVPP
     HV
//
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