ID M7TWY0_BOTF1 Unreviewed; 502 AA.
AC M7TWY0;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=3-hydroxyisobutyryl-CoA hydrolase {ECO:0000256|ARBA:ARBA00011915};
DE EC=3.1.2.4 {ECO:0000256|ARBA:ARBA00011915};
GN ORFNames=BcDW1_3189 {ECO:0000313|EMBL:EMR88166.1};
OS Botryotinia fuckeliana (strain BcDW1) (Noble rot fungus) (Botrytis
OS cinerea).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Sclerotiniaceae; Botrytis.
OX NCBI_TaxID=1290391 {ECO:0000313|EMBL:EMR88166.1, ECO:0000313|Proteomes:UP000012045};
RN [1] {ECO:0000313|Proteomes:UP000012045}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BcDW1 {ECO:0000313|Proteomes:UP000012045};
RX PubMed=23704180; DOI=10.1128/genomea.00252-13;
RA Blanco-Ulate B., Allen G., Powell A.L., Cantu D.;
RT "Draft genome sequence of Botrytis cinerea BcDW1, inoculum for noble rot of
RT grape berries.";
RL Genome Announc. 1:E0025213-E0025213(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-
CC methylpropanoate + CoA + H(+); Xref=Rhea:RHEA:20888,
CC ChEBI:CHEBI:11805, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57340; EC=3.1.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001709};
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DR EMBL; KB707799; EMR88166.1; -; Genomic_DNA.
DR AlphaFoldDB; M7TWY0; -.
DR STRING; 1290391.M7TWY0; -.
DR HOGENOM; CLU_009834_22_0_1; -.
DR Proteomes; UP000012045; Unassembled WGS sequence.
DR GO; GO:0003860; F:3-hydroxyisobutyryl-CoA hydrolase activity; IEA:UniProtKB-EC.
DR CDD; cd06558; crotonase-like; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR045004; ECH_dom.
DR InterPro; IPR018376; Enoyl-CoA_hyd/isom_CS.
DR InterPro; IPR032259; HIBYL-CoA-H.
DR PANTHER; PTHR43176:SF3; 3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43176; 3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED; 1.
DR Pfam; PF16113; ECH_2; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR PROSITE; PS00166; ENOYL_COA_HYDRATASE; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:EMR88166.1}.
FT DOMAIN 52..402
FT /note="Enoyl-CoA hydratase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF16113"
SQ SEQUENCE 502 AA; 56111 MW; 27F473F85222D3F6 CRC64;
MPLRAKIINP AFAGRAQMAT ASDTPSYAQA EVIKELESDE KEDVLFNSLY GVRTIELNRP
QKLHSLNGSM IRKIVPRLQE WSKSDMANVI IIKGSGPKAF CAGGDVAALA EDNTKGEEGQ
ARSTDYFALE YKLDHLIATY QKPYVAFMDG ITMGGGVGLS IHAPFRIATE RTLFAMPETT
IGFFPDVGAS FFLPKMSGSV GTYLALTSDR LKGVNAFYSG IATHYIHSTS LPALEKRLAE
LRFKDFETLA QRAQLINSTI EEYCTGLPHD EPMLISGELR KAIDRHFSKA SVPEIITGLK
AEIEVLKAGA EETGLENPLQ AWLEKTLATL HQRSPTSVHV ALRQMRIGKD WSITETFQRE
YQMAAKFMRH PDFTEGIDSL LIRKDKNPQW KPKTLEDISP EDKIADPFFA VEGSQRIKLL
SDRDYYEYPF QFGVPRESEV EKVVRQGGKS AFQVVNHFLQ ATEGKQGVKE VVTEIIERKT
TKSGLGYLEW EQDKISSPKS SE
//
