ID   M7U4J4_BOTF1            Unreviewed;       845 AA.
AC   M7U4J4;
DT   29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2013, sequence version 1.
DT   27-MAR-2024, entry version 41.
DE   SubName: Full=Putative peptidase a1 protein {ECO:0000313|EMBL:EMR88554.1};
GN   ORFNames=BcDW1_2892 {ECO:0000313|EMBL:EMR88554.1};
OS   Botryotinia fuckeliana (strain BcDW1) (Noble rot fungus) (Botrytis
OS   cinerea).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Helotiales; Sclerotiniaceae; Botrytis.
OX   NCBI_TaxID=1290391 {ECO:0000313|EMBL:EMR88554.1, ECO:0000313|Proteomes:UP000012045};
RN   [1] {ECO:0000313|Proteomes:UP000012045}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BcDW1 {ECO:0000313|Proteomes:UP000012045};
RX   PubMed=23704180; DOI=10.1128/genomea.00252-13;
RA   Blanco-Ulate B., Allen G., Powell A.L., Cantu D.;
RT   "Draft genome sequence of Botrytis cinerea BcDW1, inoculum for noble rot of
RT   grape berries.";
RL   Genome Announc. 1:E0025213-E0025213(2013).
CC   -!- SIMILARITY: Belongs to the peptidase A1 family.
CC       {ECO:0000256|ARBA:ARBA00007447}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KB707785; EMR88554.1; -; Genomic_DNA.
DR   AlphaFoldDB; M7U4J4; -.
DR   STRING; 1290391.M7U4J4; -.
DR   HOGENOM; CLU_009988_0_0_1; -.
DR   Proteomes; UP000012045; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   CDD; cd05471; pepsin_like; 1.
DR   Gene3D; 2.40.70.10; Acid Proteases; 2.
DR   InterPro; IPR001461; Aspartic_peptidase_A1.
DR   InterPro; IPR034164; Pepsin-like_dom.
DR   InterPro; IPR033121; PEPTIDASE_A1.
DR   InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR   PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR   PANTHER; PTHR47966:SF89; SACCHAROPEPSIN; 1.
DR   Pfam; PF00026; Asp; 1.
DR   PRINTS; PR00792; PEPSIN.
DR   SUPFAM; SSF50630; Acid proteases; 1.
DR   PROSITE; PS51767; PEPTIDASE_A1; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius}; Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           24..845
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004086347"
FT   TRANSMEM        439..462
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          50..403
FT                   /note="Peptidase A1"
FT                   /evidence="ECO:0000259|PROSITE:PS51767"
FT   REGION          489..525
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          722..762
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          811..845
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        729..759
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        828..845
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   845 AA;  91124 MW;  AEC9F5CE7EAC06F6 CRC64;
     MSSWRYLAFF LLPILGLLEQ TLASATSATP VPPLTVLPSG NWNGIDGNWS SFWLTVGTPP
     QPVLVFISTA SNQPWVVSPD GCSPSDPGTC YSSRGLNFNS NSSATWVPNT INPGGEFALE
     VESSLGLTGN GDYGNDTILL GSPGSGSPSL SSQVLATIAT HDFWLGLFGL NPAPTNFSSK
     TEPAPSYMSN LKSQGHIPSL SYGYTAGAYY RNGGGANGGG VLGNLTLGGY EESLFVPNNL
     TVDFATSGDD LTIDVNAITV KSPGGTSQVV SSPSSSFPAF IDSSVPYLYL PTSICQKFEE
     AIGISYDSES ELYLLTDAQH TALVNRNASV VFTLTNSTSK AMVNITLPYA AFDWWAEYPL
     VQNSTRYFPL KRATDNSQIT LGRAFLQEAY LIADYERSQF SIHQRNWTTF YPTSNPTTIF
     PLNNPAPLSS SKSKISTPVI AAIVLAILTS IALTLCLTIF ILHRVHQRKQ TPGRSNTVST
     FASTSRSLSK KESFRSAPSS PLPLPFISSK DKSDKKSKHV SNAPSELSFF DKGTNSVLLT
     PSNRSLVSLN IGKAIGSPNL TLNPQYNNSG VSISRNPSQS NAADTVLNKN LNLVPTEPKP
     AFHLASLSTR RKERKKKRKE KAQEIYELSG GSDALCWAEM DEMDEELEEM DMDSRASSPA
     LSALSFASDA ALITSNPEKP KPWMDNDREI RGSGSIMNMG MNRDSGMERM NRMDKEAEAY
     RERSGGHSHP GTGNDTVTTN NSRGRESHFT NTTMGLDTPT DGVGTGGTWE FEKYLDASRL
     PWVQRGSGLG VVVEPPSPVA QPVAAMPALR EGAQAPGKKV EIVNDSMKSS GQKRESEKGV
     IWGRF
//