ID M7UW15_BOTF1 Unreviewed; 408 AA.
AC M7UW15;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Putative c-3 sterol dehydrogenase c-4 decarboxylase protein {ECO:0000313|EMBL:EMR88052.1};
GN ORFNames=BcDW1_3267 {ECO:0000313|EMBL:EMR88052.1};
OS Botryotinia fuckeliana (strain BcDW1) (Noble rot fungus) (Botrytis
OS cinerea).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Sclerotiniaceae; Botrytis.
OX NCBI_TaxID=1290391 {ECO:0000313|EMBL:EMR88052.1, ECO:0000313|Proteomes:UP000012045};
RN [1] {ECO:0000313|Proteomes:UP000012045}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BcDW1 {ECO:0000313|Proteomes:UP000012045};
RX PubMed=23704180; DOI=10.1128/genomea.00252-13;
RA Blanco-Ulate B., Allen G., Powell A.L., Cantu D.;
RT "Draft genome sequence of Botrytis cinerea BcDW1, inoculum for noble rot of
RT grape berries.";
RL Genome Announc. 1:E0025213-E0025213(2013).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004406}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004406}.
CC -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC {ECO:0000256|ARBA:ARBA00009219}.
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DR EMBL; KB707802; EMR88052.1; -; Genomic_DNA.
DR AlphaFoldDB; M7UW15; -.
DR STRING; 1290391.M7UW15; -.
DR HOGENOM; CLU_007383_6_8_1; -.
DR Proteomes; UP000012045; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 309..331
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 10..312
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF01073"
SQ SEQUENCE 408 AA; 45626 MW; D9B72D737B2A8B38 CRC64;
MQSQALGHVL VIGGCGFMGH HLVKALLDDS NVEHVSVFSR SPRENRYPEA SYYAGDITSV
EEVTNLLKDI QPRIIFHAAS PDPYQDPPNH LSYQKVNVEG TKNLLACASS APSVVALVYT
SSLTIYKYDV NGEIFNADES HPILNGPVTK YNPYTESKAL ADALVLAANN PSSRPCHLAG
KCSHSHLRTA CIRIPGIYGE GDENMTMLGL QLARYGLSFL QLGDNTTLFD PIYVSNAVFG
HVLAAKALLT EVEADIAYTK DRDEDIDAVP PKSRICGEAF NITDDLPSPF WFYMRKFYTA
AGHPPKTIWV IPTWILFMLA WLTEYWFWIV YQGRRRPKIL IRSKLEHLCM TRTYQVSKAK
QKLGWYALVD IDEAAKNSMR WGLAKLGVDV KHMGSVGNQV QNERRKAA
//
