ID M7XQF5_RHOT1 Unreviewed; 1604 AA.
AC M7XQF5;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Rho GTPase-activating protein {ECO:0000313|EMBL:EMS22438.1};
GN ORFNames=RHTO_00717 {ECO:0000313|EMBL:EMS22438.1};
OS Rhodotorula toruloides (strain NP11) (Yeast) (Rhodosporidium toruloides).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina;
OC Microbotryomycetes; Sporidiobolales; Sporidiobolaceae; Rhodotorula.
OX NCBI_TaxID=1130832 {ECO:0000313|EMBL:EMS22438.1, ECO:0000313|Proteomes:UP000016926};
RN [1] {ECO:0000313|EMBL:EMS22438.1, ECO:0000313|Proteomes:UP000016926}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NP11 {ECO:0000313|EMBL:EMS22438.1,
RC ECO:0000313|Proteomes:UP000016926};
RX PubMed=23047670; DOI=10.1038/ncomms2112;
RA Zhu Z., Zhang S., Liu H., Shen H., Lin X., Yang F., Zhou Y.J., Jin G.,
RA Ye M., Zou H., Zou H., Zhao Z.K.;
RT "A multi-omic map of the lipid-producing yeast Rhodosporidium toruloides.";
RL Nat. Commun. 3:1112-1112(2012).
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DR EMBL; KB722651; EMS22438.1; -; Genomic_DNA.
DR RefSeq; XP_016273557.1; XM_016414401.1.
DR GeneID; 27364730; -.
DR eggNOG; KOG1703; Eukaryota.
DR eggNOG; KOG2710; Eukaryota.
DR HOGENOM; CLU_001321_2_1_1; -.
DR OrthoDB; 1329523at2759; -.
DR Proteomes; UP000016926; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd09391; LIM1_Lrg1p_like; 1.
DR CDD; cd09392; LIM2_Lrg1p_like; 1.
DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 4.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR001781; Znf_LIM.
DR PANTHER; PTHR14963; RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED; 1.
DR PANTHER; PTHR14963:SF1; RHO GTPASE-ACTIVATING PROTEIN CONUNDRUM; 1.
DR Pfam; PF00412; LIM; 2.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00132; LIM; 3.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 3.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR PROSITE; PS50023; LIM_DOMAIN_2; 3.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW LIM domain {ECO:0000256|PROSITE-ProRule:PRU00125};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00125};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00125}.
FT DOMAIN 328..390
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 393..453
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 793..873
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 1218..1420
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 502..526
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 725..764
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 908..1048
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1060..1100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1113..1145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1464..1604
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..49
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..72
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 91..108
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 166..293
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 294..323
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 510..524
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 923..943
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 944..978
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1018..1032
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1034..1048
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1069..1100
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1498..1537
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1538..1552
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1562..1581
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1604 AA; 172877 MW; 14CDC1B9980466C5 CRC64;
MSSRQPEAST SAHPFEHPVA HSPLSTSPTR YGDHDHLAAH AHYDGSSRRN QPARDGSGSS
GASPSRTGSR GPSPARGGSG DSDGGAYRRK GSDTMSSSRQ NSGERGLGQI QEHSEAGLAG
RGAGGQGLGR GGGLPVLNTH MLPVGHGLLS PASPAYPHHP NDSRASLLPR QRSGSHSYSP
SHGLPSSSST RATPSPTFPP SHSNSTLSSH SHSHSQSGLR SPITTNFPNS SSSTTHTHPT
TASNSPLMHP PSRPSSSASH SQQSHSRSQS QNPSADGHSR TSGSRSRGNS ATSVDGRESE
RGRDDGTPGG KAERREKDRS RKERMAAATC AKCELPMTGQ FVRALGTVYH LDCFRCMDCG
KMVAAKFFPI DATDGSGRQV PLCETDYFRR LNLLCAKCGQ ALRGSYITAL DMKFHVEHFT
CEVCPTVFGP QDSYYEHDGS VYCHFHYSTR FAVKCTGCRT AILKQFVEIN RNSVDEHWHP
ECYMIHKFWN IKLAPAPKAV EALPPSDPSD HSIATVSDSS TSAPPPPEYL AIEASETPGS
LKARQKHMEE QVYRIWTILS AFEESSAACI SEMLRHVSSG HYMEGVGMAE KFVLHVETLF
AAIDDLNEAF RRAGAKELQH VREARMLCKK VVNFFMLLSH THETGARKMS ITQDLLSLVT
GLAHYLKILI RIALAGSLKL EREHGNVQAI GLFLGRLDRL ARDPEANKIS ATMLALARKG
GARNASSARA GLGPATSTAP NRKDSDRSAE SASGDEANGG SHVAPVLARP TYGYKSLARA
IGTLVGQGEA TTDLCEGCRL TIEEECVRHG TSIRWHLPCL RCAQCHRLAT KDDSTANASA
LLPLADFVWV PAGGEGGQGS TVCKECARRE RGGSLEGTVD GFAHVTRLEQ YAFLLCVALN
KLYGRLKQRG VVPGTPPDGE ETRSLSDAYR DSSDIKRMKS VQLDRKLSAT TARVPQRSTV
IQSPSGRTAQ SDATDPTFQL FQAKPPVPSR KDQPLVDPVR GTTIPRSQVR EVAPPSSGGA
TPTPSNAVTP TPSPGLAGPA PLPPSATLPA AVQRPHFNRA TTAVRIVDDP PPKTEDVPSG
EVREREGLGG TSEPTKDEEG LTLADLPKAL EAEQKRAAAP DYQAGRSPLS DPREQSRPYA
SPANNGPKLL SELSALEYFI VKHVSAVLLS SETSALCDVA PLDDLLDIID ARKNTFWGKL
FKAGGEKKKV PKKGVFGIPL EVLVERNGAD SMHGAGPGSL RVPSFVDDVI SAMKQMDMSI
EGIFRKNGNI RRLKDLTEAL DRDASSVNLS DDNPVQLAAL LKKFLRDLPD PLMTFKLFHL
FIAAQRVDDP EARKKALHYC CCMMPKAHRD TMEVVFVFLK WVASFSHVDE ETGSKMDLQN
LATVISPNIL YAKGKDPARD ESFSAARVVH ELLEMQDEFW EVPAECLSIL NDQELFSNPS
QLTSKEILAR AENHIRLNGR ATHWKVSRGE ASPPRRPGLQ EAWSAPAVPG GGGGSRPIST
YASPSPFRSP ERPTSYSNQP SSGGGGGPNA NGAPQPWSTG SPPWPPAPPP EDRFEAPYRR
GTEATGSSSS LHRQAYSESG QPPFPSHPMP HTSSSHPYQR AAGR
//
