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Database: UniProt
Entry: M7Y066_9RHIZ
LinkDB: M7Y066_9RHIZ
Original site: M7Y066_9RHIZ 
ID   M7Y066_9RHIZ            Unreviewed;       425 AA.
AC   M7Y066;
DT   29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2013, sequence version 1.
DT   16-JAN-2019, entry version 32.
DE   RecName: Full=Phosphoribosylamine--glycine ligase {ECO:0000256|HAMAP-Rule:MF_00138};
DE            EC=6.3.4.13 {ECO:0000256|HAMAP-Rule:MF_00138};
DE   AltName: Full=GARS {ECO:0000256|HAMAP-Rule:MF_00138};
DE   AltName: Full=Glycinamide ribonucleotide synthetase {ECO:0000256|HAMAP-Rule:MF_00138};
DE   AltName: Full=Phosphoribosylglycinamide synthetase {ECO:0000256|HAMAP-Rule:MF_00138};
GN   Name=purD {ECO:0000256|HAMAP-Rule:MF_00138};
GN   ORFNames=MmSR116_4651 {ECO:0000313|EMBL:EMS40246.1};
OS   Methylobacterium mesophilicum SR1.6/6.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Methylobacteriaceae; Methylobacterium.
OX   NCBI_TaxID=908290 {ECO:0000313|EMBL:EMS40246.1, ECO:0000313|Proteomes:UP000012488};
RN   [1] {ECO:0000313|EMBL:EMS40246.1, ECO:0000313|Proteomes:UP000012488}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SR1.6/6 {ECO:0000313|EMBL:EMS40246.1,
RC   ECO:0000313|Proteomes:UP000012488};
RX   PubMed=23788544;
RA   Marinho Almeida D., Dini-Andreote F., Camargo Neves A.A.,
RA   Juca Ramos R.T., Andreote F.D., Carneiro A.R.,
RA   Oliveira de Souza Lima A., Caracciolo Gomes de Sa P.H.,
RA   Ribeiro Barbosa M.S., Araujo W.L., Silva A.;
RT   "Draft Genome Sequence of Methylobacterium mesophilicum Strain
RT   SR1.6/6, Isolated from Citrus sinensis.";
RL   Genome Announc. 1:E00356-13(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-phospho-D-ribosylamine + ATP + glycine = ADP + H(+) +
CC         N(1)-(5-phospho-D-ribosyl)glycinamide + phosphate;
CC         Xref=Rhea:RHEA:17453, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:57305, ChEBI:CHEBI:58089,
CC         ChEBI:CHEBI:58457, ChEBI:CHEBI:456216; EC=6.3.4.13;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_00138};
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC       N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-
CC       ribose 1-diphosphate: step 2/2. {ECO:0000256|HAMAP-Rule:MF_00138}.
CC   -!- SIMILARITY: Belongs to the GARS family. {ECO:0000256|HAMAP-
CC       Rule:MF_00138}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EMS40246.1}.
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DR   EMBL; ANPA01000016; EMS40246.1; -; Genomic_DNA.
DR   RefSeq; WP_010686426.1; NZ_ANPA01000016.1.
DR   EnsemblBacteria; EMS40246; EMS40246; MmSR116_4651.
DR   PATRIC; fig|908290.3.peg.4710; -.
DR   UniPathway; UPA00074; UER00125.
DR   Proteomes; UP000012488; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0004637; F:phosphoribosylamine-glycine ligase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0009113; P:purine nucleobase biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.30.1490.20; -; 1.
DR   Gene3D; 3.90.600.10; -; 1.
DR   HAMAP; MF_00138; GARS; 1.
DR   InterPro; IPR011761; ATP-grasp.
DR   InterPro; IPR013815; ATP_grasp_subdomain_1.
DR   InterPro; IPR016185; PreATP-grasp_dom_sf.
DR   InterPro; IPR020561; PRibGlycinamid_synth_ATP-grasp.
DR   InterPro; IPR000115; PRibGlycinamide_synth.
DR   InterPro; IPR020560; PRibGlycinamide_synth_C-dom.
DR   InterPro; IPR037123; PRibGlycinamide_synth_C_sf.
DR   InterPro; IPR020559; PRibGlycinamide_synth_CS.
DR   InterPro; IPR020562; PRibGlycinamide_synth_N.
DR   InterPro; IPR011054; Rudment_hybrid_motif.
DR   Pfam; PF01071; GARS_A; 1.
DR   Pfam; PF02843; GARS_C; 1.
DR   Pfam; PF02844; GARS_N; 1.
DR   SMART; SM01210; GARS_C; 1.
DR   SUPFAM; SSF51246; SSF51246; 1.
DR   SUPFAM; SSF52440; SSF52440; 1.
DR   TIGRFAMs; TIGR00877; purD; 1.
DR   PROSITE; PS50975; ATP_GRASP; 1.
DR   PROSITE; PS00184; GARS; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00409};
KW   Complete proteome {ECO:0000313|Proteomes:UP000012488};
KW   Ligase {ECO:0000256|HAMAP-Rule:MF_00138, ECO:0000313|EMBL:EMS40246.1};
KW   Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00409};
KW   Purine biosynthesis {ECO:0000256|HAMAP-Rule:MF_00138}.
FT   DOMAIN      108    309       ATP-grasp. {ECO:0000259|PROSITE:PS50975}.
SQ   SEQUENCE   425 AA;  43856 MW;  2F7C93D95F79A61C CRC64;
     MNILLIGSGG REHALAWRLA QSPLCTRLFT APGNPGTARH GTNRSDLSVT DHAAVAAFCA
     AESIGLVVVG PEAPLVAGLV DDLKAAGIRA FGPTRDAARL EGSKGFTKDL CAACGIPTAA
     FARFTELEPA LAYTRQQGAP IVVKADGLAA GKGVTVAETL DQAEDALAAL FEEPGAEVVV
     EECLFGEEAS FFALCDGTRA IPLGTAQDHK RVFDGDRGPN TGGMGAYSPA RVVTPEIEAR
     VMAEIIAPTL AGMRARGCPF TGILYAGLML TADGPKLIEY NTRFGDPEAQ VLMPRLSSDL
     VPALLSACEG DLSGVSLEFD AHRAALTVVM AAAGYPGAVV RGSVIRGVDA AEGDGVFVFQ
     AGTRAEDGQL LADGGRVLAV TALGDSVTDA QARAYAAVAR IDWPEGFCRR DIGFRAVARE
     AGGEG
//
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