ID M7Y1J4_9BACT Unreviewed; 1428 AA.
AC M7Y1J4;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=C943_02659 {ECO:0000313|EMBL:EMS31086.1};
OS Mariniradius saccharolyticus AK6.
OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Cyclobacteriaceae;
OC Mariniradius.
OX NCBI_TaxID=1239962 {ECO:0000313|EMBL:EMS31086.1, ECO:0000313|Proteomes:UP000010953};
RN [1] {ECO:0000313|EMBL:EMS31086.1, ECO:0000313|Proteomes:UP000010953}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AK6 {ECO:0000313|EMBL:EMS31086.1,
RC ECO:0000313|Proteomes:UP000010953};
RA Vaidya B., Khatri I., Tanuku N.R.S., Subramanian S., Pinnaka A.;
RT "Genome assembly of Mariniradius saccharolyticus AK6.";
RL Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMS31086.1}.
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DR EMBL; AMZY02000023; EMS31086.1; -; Genomic_DNA.
DR RefSeq; WP_008631618.1; NZ_AMZY02000023.1.
DR STRING; 1239962.C943_02659; -.
DR eggNOG; COG0587; Bacteria.
DR InParanoid; M7Y1J4; -.
DR OrthoDB; 9803237at2; -.
DR Proteomes; UP000010953; Unassembled WGS sequence.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd06127; DEDDh; 1.
DR CDD; cd04485; DnaE_OBF; 1.
DR CDD; cd12113; PHP_PolIIIA_DnaE3; 1.
DR Gene3D; 1.10.150.870; -; 1.
DR Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR004805; DnaE2/DnaE/PolC.
DR InterPro; IPR029460; DNAPol_HHH.
DR InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR NCBIfam; TIGR00594; polc; 1.
DR PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR PANTHER; PTHR32294:SF0; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF14579; HHH_6; 1.
DR Pfam; PF02811; PHP; 1.
DR Pfam; PF00929; RNase_T; 1.
DR SMART; SM00479; EXOIII; 1.
DR SMART; SM00481; POLIIIAc; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE 4: Predicted;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000010953};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1..191
FT /note="Exonuclease"
FT /evidence="ECO:0000259|SMART:SM00479"
FT DOMAIN 246..313
FT /note="Polymerase/histidinol phosphatase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00481"
SQ SEQUENCE 1428 AA; 161003 MW; 5D8561829D545892 CRC64;
MYIIFDTETT GLPRNYDAPM EDLDNWPRLV QIAWQLHDAR GKLLSNHNYI VKPEGFTIPY
NAEKVHGIST ARALKEGHDL EKVLGIFDED LKKATYVVGH NIGFDINVVG SEFLRKKLPM
KLRDRKELDT KDLSTDFCAI PGGKGGKFKW PTLTELHHKL FGNGFADAHD AAYDVDATAK
CFFGLITQRV IQPEKGIPLA EVVYEPPRLD AANFANAKDD TKTAAKEILK AAGTADISQM
QDLPFTHLHV HTQYSVLQAT SEIPSLIALA KSMNMPAIAM TDHGNMMGAF HFVKEAFSKG
IKPIIGCEFN LCKDRKNKSQ KDDGYQTVLI AKNKGGYHNL AKLASYANIE GYYYVPRIDK
ELLVQYKSDL IATTGGLWSE IPYLILNVGD TQAEEAFIWW KEQFGEDFYV ELNRHGIPEE
EKVNEVLLHF AKKYGVKFFA ANNAYYNQKV DAKAHDILLC VKDGELVEKP KKYIGKRGRE
FRFGFPNDEF YIKSPEEMKK LFADLPEAIA CTDEIVQKIE SYKLERPVLL PKFDIPDEFK
DPQDEIDGGK RGENAYLRYL TYEGAKKRYP DLTDEIKERL DFELATIEKT GYPGYFLIVQ
DFTGEARKMG VSVGPGRGSA AGSAVAYCTG ITNVDPIAYD LLFERFLNPD RVSLPDIDID
FDDEGRDKVI KYVIDKYGSN QVAQIITYGT MAAKSAIRDT ARVLNLPLAE ADKLAKLVPD
IKLKALFDLS KDRAKLADKL KGNGEDLSKA EELIRISKGQ DELSKTVNQA TVLEGSVRNT
GIHACGVIIT PDDITNFVPV ALAKDSDMVC TQFDNSVVES AGLLKMDFLG LKTLTLIKDA
VKIVKERHGI DLDPDNFPID DAKTYELFQR GETVGIFQYE SPGMQKYMRD LKPTVFADLI
AMNALYRPGP LEYIPSFVRR KHGQEPITYD LDDMKEYLEE TYGITVYQEQ VMLLSQKLAG
FTKGEADVLR KAMGKKQKDV LDKMKPKFVE QASAKGHDAQ KLEKIWKDWE AFASYAFNKS
HSTCYAWIAY QTAYLKAHYP AEYMASVLSN NMNDITQVTF FMEECKRMGI SVLGPDVNES
KSGFTVNKDG QIRFGLAAIK GAGAAAVEAI IVEREKSGRY QTIFDFCKRV NSRALNKKTL
EALAMAGSFD CFPQHHRRQY LEAPEGDVTL LEKAVKYAQK VQQESESNQV SLFGGGSGME
VSLPTVASME PFSQLQQLNI EKEVVGLYIS GHPLDQFRVE IDAFTNTPLP EFADIENLRK
KSDIKAAGIV TSFAHRTTKT GKPFGTLSME DYHGAHTFFL FGDDYIKFKG YFMTGWFLYL
SGSVHPNKFK ENEFEFKINM IMLLNEVRGK MVKGLRVNID LDDLSFELME KLEAITQRYR
GDAKLYINII DSKENITLDL MSKRFTVDPS NEMIKELGRI PEVVYEIV
//
