ID M7Y882_TRIUA Unreviewed; 1328 AA.
AC M7Y882;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN ORFNames=TRIUR3_27986 {ECO:0000313|EMBL:EMS46218.1};
OS Triticum urartu (Red wild einkorn) (Crithodium urartu).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4572 {ECO:0000313|EMBL:EMS46218.1};
RN [1] {ECO:0000313|EMBL:EMS46218.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23535596; DOI=10.1038/nature11997;
RA Ling H.Q., Zhao S., Liu D., Wang J., Sun H., Zhang C., Fan H., Li D.,
RA Dong L., Tao Y., Gao C., Wu H., Li Y., Cui Y., Guo X., Zheng S., Wang B.,
RA Yu K., Liang Q., Yang W., Lou X., Chen J., Feng M., Jian J., Zhang X.,
RA Luo G., Jiang Y., Liu J., Wang Z., Sha Y., Zhang B., Wu H., Tang D.,
RA Shen Q., Xue P., Zou S., Wang X., Liu X., Wang F., Yang Y., An X., Dong Z.,
RA Zhang K., Zhang X., Luo M.C., Dvorak J., Tong Y., Wang J., Yang H., Li Z.,
RA Wang D., Zhang A., Wang J.;
RT "Draft genome of the wheat A-genome progenitor Triticum urartu.";
RL Nature 496:87-90(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|RuleBase:RU000442};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC {ECO:0000256|ARBA:ARBA00005755, ECO:0000256|RuleBase:RU000442}.
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DR EMBL; KD276699; EMS46218.1; -; Genomic_DNA.
DR STRING; 4572.M7Y882; -.
DR eggNOG; KOG0970; Eukaryota.
DR OMA; WNERTAD; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:1902975; P:mitotic DNA replication initiation; IEA:InterPro.
DR CDD; cd05776; DNA_polB_alpha_exo; 1.
DR CDD; cd05532; POLBc_alpha; 1.
DR Gene3D; 3.30.70.2820; -; 1.
DR Gene3D; 1.10.3200.20; DNA Polymerase alpha, zinc finger; 1.
DR Gene3D; 1.10.132.60; DNA polymerase family B, C-terminal domain; 1.
DR Gene3D; 1.10.287.690; Helix hairpin bin; 1.
DR Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR042087; DNA_pol_B_thumb.
DR InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR InterPro; IPR038256; Pol_alpha_znc_sf.
DR InterPro; IPR045846; POLBc_alpha.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR015088; Znf_DNA-dir_DNA_pol_B_alpha.
DR NCBIfam; TIGR00592; pol2; 1.
DR PANTHER; PTHR45861; DNA POLYMERASE ALPHA CATALYTIC SUBUNIT; 1.
DR PANTHER; PTHR45861:SF1; DNA POLYMERASE ALPHA CATALYTIC SUBUNIT; 1.
DR Pfam; PF00136; DNA_pol_B; 1.
DR Pfam; PF03104; DNA_pol_B_exo1; 1.
DR Pfam; PF08996; zf-DNA_Pol; 1.
DR PRINTS; PR00106; DNAPOLB.
DR SMART; SM00486; POLBc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|RuleBase:RU000442};
KW DNA-binding {ECO:0000256|RuleBase:RU000442};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW ECO:0000256|RuleBase:RU000442};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU000442};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU000442};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 260..567
FT /note="DNA-directed DNA polymerase family B exonuclease"
FT /evidence="ECO:0000259|Pfam:PF03104"
FT DOMAIN 633..1083
FT /note="DNA-directed DNA polymerase family B
FT multifunctional"
FT /evidence="ECO:0000259|Pfam:PF00136"
FT DOMAIN 1123..1324
FT /note="Zinc finger DNA-directed DNA polymerase family B
FT alpha"
FT /evidence="ECO:0000259|Pfam:PF08996"
SQ SEQUENCE 1328 AA; 147951 MW; A94A8387A1DBC369 CRC64;
MMGKQRLSSM FTSSVFKKPG SDRTKGSSLA ADSIVDDVIA EFAPDENDRE ERRRRVGRVS
APTPTPAPVA QIKAIQAAVH AEMEVRSDNG FEPDVVSDHG NDMEVELQPE VELKPDVEMQ
PKLEAAPGSS AELVDENKSS EELKQEANGE VKIEKVHRLN AKIKAEGTRN GDMLSATAGW
MKICGEGENA GGEGEVSVNG NTDVDESSEF ELKDGALPFY VLDAYEEPFG INSGTVYLFG
KELSSGLKSE VAEKLSDLNV SSFVMTPVKR NYAFERTDVP IGEQYVLKIN YPYKDPAVPA
DLRGEHFHVL LGTNNSALEL FLIKRKIKGP SWLSISKFVA CPSTQRVSWC KFEVTVDSPK
DISVLMTSTT LEVPPVVVAA VNLKTVINEK HNVHEIVSAS VICCHQVKID TPMRSEDWQK
RGTISHFTVM RKLEGSIFPI GLTKEASDRN QKAGSNVLAL ESSERALLNR LMIELSKLDC
DVLVGHNISG FDLDVLLHRA QTCKVPSSMW SKIGRLRRSV MPRLTKGNTL YGSGASPGII
SCIAGRLLCD TYLCSRDLLR EVSYSLTQLA ETQLKKDRRE VSPHDIPPMF QSSGTLLKLV
EYGETDAWLS LELMFHLSVL PLTRQLTNIS GNLWGKTLQG ARAQRVEYLL LHSFHAKKFI
IPDKFAARNK ELNSAKRKLN ADTEGGNAAD GAADPSIDDE VHNGDQGKAR KGPSYAGGLV
LEPKKGLYDK YILLLDFNSL YPSIIQEFNI CFTTVERSSD GNLPNLPTSK ATGVLPELLK
SLVERRRMVK SWLKTASGLK RQQFDIQQQA LKLTANRFFA KPLAELITLQ GREILQNTVD
LVQNNLNLEV IYGDTDSIMI YTGLDDISKA KAIAGKVIQE VNKKYRCLEI DLDGVYKRML
LLKKKKYAAI KVALDGSLRE NIERKGLDMV RRDWSLLSKE IGDFCLNQIL SGGTCDDVIE
SIHNSLVQVQ AQMKSGQIEL EKYIITKSLT KAPEDYPDAK NQPHVQVALR LKQNGFSGCS
AGDTVPYIIC SQQDSDNTHS GGIAQRARHP DELKRDPNKW MIDIEYYLSQ QIHPVVSRLC
ASIEGTSPAR LAECLGLDSS KFQSRSIGSS NEDTSTMLLS VIDDEDERYR GCEPLRLSCP
SCTNTFECPP VSSLIASLSD PNEGKDATVN FWRRMRCPRC PDDTDECRVS PAVLANQIKR
QADNFINRYY KGLLMCDDEG CKYSTHIVNL RVMGDSERGT ICPNYPQCNG RLVRQYTEAD
LYRQLSYFCY VLDATRCLDK LDQKMRLPFE KEFAVLNQTI SLAFLEIQKI RDRCAFGWVQ
LTDLAVSI
//
