ID   M7ZH92_TRIUA            Unreviewed;      1730 AA.
AC   M7ZH92;
DT   29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2013, sequence version 1.
DT   27-MAR-2024, entry version 68.
DE   RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE            EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
GN   ORFNames=TRIUR3_15663 {ECO:0000313|EMBL:EMS62548.1};
OS   Triticum urartu (Red wild einkorn) (Crithodium urartu).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX   NCBI_TaxID=4572 {ECO:0000313|EMBL:EMS62548.1};
RN   [1] {ECO:0000313|EMBL:EMS62548.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23535596; DOI=10.1038/nature11997;
RA   Ling H.Q., Zhao S., Liu D., Wang J., Sun H., Zhang C., Fan H., Li D.,
RA   Dong L., Tao Y., Gao C., Wu H., Li Y., Cui Y., Guo X., Zheng S., Wang B.,
RA   Yu K., Liang Q., Yang W., Lou X., Chen J., Feng M., Jian J., Zhang X.,
RA   Luo G., Jiang Y., Liu J., Wang Z., Sha Y., Zhang B., Wu H., Tang D.,
RA   Shen Q., Xue P., Zou S., Wang X., Liu X., Wang F., Yang Y., An X., Dong Z.,
RA   Zhang K., Zhang X., Luo M.C., Dvorak J., Tong Y., Wang J., Yang H., Li Z.,
RA   Wang D., Zhang A., Wang J.;
RT   "Draft genome of the wheat A-genome progenitor Triticum urartu.";
RL   Nature 496:87-90(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC         [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC         cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC         EC=2.3.2.26; Evidence={ECO:0000256|ARBA:ARBA00000885};
CC   -!- SIMILARITY: Belongs to the UPL family. K-HECT subfamily.
CC       {ECO:0000256|ARBA:ARBA00006331}.
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DR   EMBL; KD080692; EMS62548.1; -; Genomic_DNA.
DR   STRING; 4572.M7ZH92; -.
DR   eggNOG; KOG0168; Eukaryota.
DR   eggNOG; KOG0170; Eukaryota.
DR   OMA; AEPLSQF; -.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   CDD; cd00078; HECTc; 1.
DR   Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000225; Armadillo.
DR   InterPro; IPR000569; HECT_dom.
DR   InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR   InterPro; IPR045322; HECTD1/TRIP12-like.
DR   PANTHER; PTHR45670; E3 UBIQUITIN-PROTEIN LIGASE TRIP12; 1.
DR   PANTHER; PTHR45670:SF1; E3 UBIQUITIN-PROTEIN LIGASE TRIP12; 1.
DR   Pfam; PF00632; HECT; 1.
DR   SMART; SM00185; ARM; 3.
DR   SMART; SM00119; HECTc; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR   PROSITE; PS50237; HECT; 1.
PE   3: Inferred from homology;
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
SQ   SEQUENCE   1730 AA;  187342 MW;  3D9AD2C597626F96 CRC64;
     MSGPNGARMK SMLAGLRADG EEGRQVEALT QLCEMLSIGT EDTLAGFSVD SFVPVLVGLL
     NHESNPDIML LAARALTHLC DVLPSSCSAV VHYGAVACFC ARLLTIEYMD LAEQSLQALK
     KISQEHPTAC LRAGALMAVL SYLDFFSTGV QRVALSTAAN MCRKLPSDAS DFVMEAVPLL
     TNLLNYHDAK VLEHASVCLT RIAESFASSP EKLDQLCNYG LVAQAASLIA VSNSAGQASL
     STLTYTGVIR VLSICASGSP LAAKTLLLHG ISGTLKDILS GSGLVAGTTV SPTRPADQNI
     QNLEESCMLD TYSVYNNLPN VSRARAVCAV LQAITMYEIV NLADELLPPL PAGTISLPAH
     SHVFMKGSSV KKPGSSKQGE SGSTDIKVSG REKLLRDQPE LLQQFGMDIL PTMTQVYGSS
     VNGPIRHKCL SVIAKLMYYS SAEMIEILHG TTNISSFLAG ILAWKDPHVL VPALQIAEIL
     MEKLPGTFSK MFVREGVVHA VESLICQEIS SPMLFQVPQQ DKDIDSGTCT SSRSRRSRRR
     SSAGNTDNNS LDEPKGSHTT IANSPPSTLE GPNTRIRASV SDRAKSFKDK YFPSEPGSSD
     IAVTDDLLKL RALCAKLNAT ADTVKTKAKG KSKSLGGDDF DILCNVEQQL DDIIDKILSE
     LSNGDGVSTF EFIGSGVISA LLNYLSCGTF GKEKVSEANL PKLRHLALRR YKAFIYVALP
     NDAVGNQTPM AFLVQKLQSA LSSLERFPVV ISHSGRTSSL GGSRPSSGLS ALSQPLKLRL
     CRAAGEKTLK DYSSNIVLID PLASLAAVED FLWPRIQRSE SISYPAVSSG KNSESVAPSA
     TAPVASSTQS VRRPSTRSKS LADADSATKK DIQEGSGNTS KGKGKAVVKS MSDEPKGPHT
     RTAARRKVAS QKDAEVKPPH GHSSSEDEEL GASPFEADDA LMLGDDDDDV SDDEDDDHEV
     LRGSLPDCVP ESVHDVKLAD ADGSSIASIA SDNQTQPSSG SSVKHTFSSR GAGSVELRNP
     STLGSRGAMS FAAAAMAGLA SVGSRGIRGS QDRRGLPLGT SAHEHSNKLI FTAGGKQLSK
     HLTVYQAMQQ QVVHDEDDEE RLGGSDLPND GSRLWSDMFT ITYQKADNEV DRESTRGSSL
     VLKSSKSELC RATSQEQCTS LLDSILQGEL PCDIEKSTQT YNILALLRVL EGLNQLSPRL
     RLQATCDDFI EGKVGTLDGL YGTGAKVPSE EFISSKLTPK LARQIQDVLA LCSGSLPSWC
     YQMTKACPFL FPFETRRQHF YSTAFGLSRA LNRLQQQQGD NNSSATEREV RIGRLQRQKV
     RVSRNRILDS AAKVMEMFSN QKAVLEVEYF GEVGTGLGPT LEFYTLLSHD LQRVGLGLWR
     SDSDSLEAKK LDSHSPADSR NLIHAPLGLF PRPWPPSTAS SEGSKFFKVV EYFRLVGRIM
     AKALQDGRLL DLPLSTAFYK LLLGQELDLY DILSFDAEFG KILQELQVLV ERKRFLESCS
     NHSQQIEELG FRGAPIQDLC LDFTLPGYPD FVLKEGEENT VVCIYNLEEY ISLVVDATLK
     TGIMRQVEAF KAGFNQVFDI SSLQIFSPQE LDYLICGRRE LWEPETLVEH IKFDHGYTSK
     SPAIVNLLEI MTEFTPEQQH AFCQFVTGAP RLPPGGLASL NPKLTIVRKH SSTAANTSNA
     AGAAESADDD LPSVMTCANY LKLPPYSTKE VMHKKLLYAI NEGQGSFDLS
//