ID M8AHR3_TRIUA Unreviewed; 450 AA.
AC M8AHR3;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=5' exonuclease Apollo {ECO:0000256|ARBA:ARBA00039555};
DE EC=3.5.2.6 {ECO:0000256|ARBA:ARBA00012865};
DE AltName: Full=DNA cross-link repair 1B protein {ECO:0000256|ARBA:ARBA00041693};
DE AltName: Full=SNM1 homolog B {ECO:0000256|ARBA:ARBA00042738};
GN ORFNames=TRIUR3_19233 {ECO:0000313|EMBL:EMS64465.1};
OS Triticum urartu (Red wild einkorn) (Crithodium urartu).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4572 {ECO:0000313|EMBL:EMS64465.1};
RN [1] {ECO:0000313|EMBL:EMS64465.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23535596; DOI=10.1038/nature11997;
RA Ling H.Q., Zhao S., Liu D., Wang J., Sun H., Zhang C., Fan H., Li D.,
RA Dong L., Tao Y., Gao C., Wu H., Li Y., Cui Y., Guo X., Zheng S., Wang B.,
RA Yu K., Liang Q., Yang W., Lou X., Chen J., Feng M., Jian J., Zhang X.,
RA Luo G., Jiang Y., Liu J., Wang Z., Sha Y., Zhang B., Wu H., Tang D.,
RA Shen Q., Xue P., Zou S., Wang X., Liu X., Wang F., Yang Y., An X., Dong Z.,
RA Zhang K., Zhang X., Luo M.C., Dvorak J., Tong Y., Wang J., Yang H., Li Z.,
RA Wang D., Zhang A., Wang J.;
RT "Draft genome of the wheat A-genome progenitor Triticum urartu.";
RL Nature 496:87-90(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a beta-lactam + H2O = a substituted beta-amino acid;
CC Xref=Rhea:RHEA:20401, ChEBI:CHEBI:15377, ChEBI:CHEBI:35627,
CC ChEBI:CHEBI:140347; EC=3.5.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00001526};
CC -!- SUBCELLULAR LOCATION: Chromosome, telomere
CC {ECO:0000256|ARBA:ARBA00004574}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA repair metallo-beta-lactamase (DRMBL)
CC family. {ECO:0000256|ARBA:ARBA00010304}.
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DR EMBL; KD055911; EMS64465.1; -; Genomic_DNA.
DR STRING; 4572.M8AHR3; -.
DR eggNOG; KOG1361; Eukaryota.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.12650; -; 1.
DR InterPro; IPR011084; DRMBL.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR PANTHER; PTHR23240:SF8; 5' EXONUCLEASE APOLLO; 1.
DR PANTHER; PTHR23240; DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED; 1.
DR Pfam; PF07522; DRMBL; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 3: Inferred from homology;
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Telomere {ECO:0000256|ARBA:ARBA00022895}.
FT DOMAIN 224..350
FT /note="DNA repair metallo-beta-lactamase"
FT /evidence="ECO:0000259|Pfam:PF07522"
SQ SEQUENCE 450 AA; 49928 MW; 9F66E512F4973ACC CRC64;
MDEGLVSVDK FSGGSQAYFL THLHQDHTRG LGAAAGXXXX XXXXLRAHRL PPRHRPPRHP
LPRYTSRPKP SSPDALARRR SVNPLTNPWP RAVRAGSLLF LLFLFRGDLG CRLYTGDFRW
ELGCDKARAA KKALLDALAG DTVDVLYLDN SYCHPSLNFP PRRVVAQQIV DLIRAHPDHE
VILGIDTLGK EDLLLYIARA LQTKIWVWPQ RLLTMHLLGI DDNREIFTTQ TSLTRVRAVP
RYGLSIESLE ALNTVCPTIG IMPSGNTWLW RNSEGKGNKF SGKGPAKSTK CKGRGRGAVG
TIEMNYDPSS PPKLFEKDSY TLPYTDHACF AELEDFMQTV RPSTVVGIVS SSYCYVNPRG
HFGHLCGDEA CSDKTPVKNG GHAGNSTPVK NGRHAGNSTP KRRPGASKAP RRRMVKISSP
TLYRSRAIMM KRRYSCGAKI VEPEEPIPVS
//
