ID   M8AID8_TRIUA            Unreviewed;       782 AA.
AC   M8AID8;
DT   29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2013, sequence version 1.
DT   27-MAR-2024, entry version 51.
DE   SubName: Full=Vacuolar cation/proton exchanger 3 {ECO:0000313|EMBL:EMS64730.1};
GN   ORFNames=TRIUR3_07360 {ECO:0000313|EMBL:EMS64730.1};
OS   Triticum urartu (Red wild einkorn) (Crithodium urartu).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX   NCBI_TaxID=4572 {ECO:0000313|EMBL:EMS64730.1};
RN   [1] {ECO:0000313|EMBL:EMS64730.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23535596; DOI=10.1038/nature11997;
RA   Ling H.Q., Zhao S., Liu D., Wang J., Sun H., Zhang C., Fan H., Li D.,
RA   Dong L., Tao Y., Gao C., Wu H., Li Y., Cui Y., Guo X., Zheng S., Wang B.,
RA   Yu K., Liang Q., Yang W., Lou X., Chen J., Feng M., Jian J., Zhang X.,
RA   Luo G., Jiang Y., Liu J., Wang Z., Sha Y., Zhang B., Wu H., Tang D.,
RA   Shen Q., Xue P., Zou S., Wang X., Liu X., Wang F., Yang Y., An X., Dong Z.,
RA   Zhang K., Zhang X., Luo M.C., Dvorak J., Tong Y., Wang J., Yang H., Li Z.,
RA   Wang D., Zhang A., Wang J.;
RT   "Draft genome of the wheat A-genome progenitor Triticum urartu.";
RL   Nature 496:87-90(2013).
CC   -!- FUNCTION: Vacuolar cation/proton exchanger (CAX). Translocates Ca(2+)
CC       and other metal ions into vacuoles using the proton gradient formed by
CC       H(+)-ATPase and H(+)-pyrophosphatase. {ECO:0000256|ARBA:ARBA00025327}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC       family. Cation/proton exchanger (CAX) subfamily.
CC       {ECO:0000256|ARBA:ARBA00008248}.
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DR   EMBL; KD052551; EMS64730.1; -; Genomic_DNA.
DR   AlphaFoldDB; M8AID8; -.
DR   STRING; 4572.M8AID8; -.
DR   eggNOG; KOG1397; Eukaryota.
DR   eggNOG; KOG4585; Eukaryota.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProt.
DR   GO; GO:0015369; F:calcium:proton antiporter activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1420.30; NCX, central ion-binding region; 2.
DR   InterPro; IPR004713; CaH_exchang.
DR   InterPro; IPR004798; CAX-like.
DR   InterPro; IPR027806; HARBI1_dom.
DR   InterPro; IPR004837; NaCa_Exmemb.
DR   InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR   NCBIfam; TIGR00378; cax; 1.
DR   PANTHER; PTHR31503; VACUOLAR CALCIUM ION TRANSPORTER; 1.
DR   PANTHER; PTHR31503:SF53; VACUOLAR CATION_PROTON EXCHANGER 3; 1.
DR   Pfam; PF13359; DDE_Tnp_4; 1.
DR   Pfam; PF01699; Na_Ca_ex; 2.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   DOMAIN          171..334
FT                   /note="DDE Tnp4"
FT                   /evidence="ECO:0000259|Pfam:PF13359"
FT   DOMAIN          457..612
FT                   /note="Sodium/calcium exchanger membrane region"
FT                   /evidence="ECO:0000259|Pfam:PF01699"
FT   DOMAIN          646..707
FT                   /note="Sodium/calcium exchanger membrane region"
FT                   /evidence="ECO:0000259|Pfam:PF01699"
SQ   SEQUENCE   782 AA;  87844 MW;  6ACCA27A41BBA2C2 CRC64;
     MEDMADGDYS DSGQMIINDF SAMSLLQHVL FGRLFKTPRN TSKLTGAQKT REWLEGHPVR
     FYEQLRVDKH TFYLLRDALC ERNLLTDTKR MDVNEQLVIF LHTIGHNVRN RVIQNRFQHS
     GETISRHFKR VLKAINGLCD VYITDPPNEV PNEILGDSRF YPYFKNCMGA IDGTHINAKI
     KLDKQTPYRN RHGYPSQNVM AVVSFDMTFS YVAAGWEGSA SDQAVLRWAV TDGGFVVPEG
     KFYLVDSGYA NTPRFIAPYR GDHYHIGSFR GTKRRYSSEK DLFNHRHTQL LRNVVERTFG
     VLKARFPILT RNGGIPYPYK KQVQIVMACC IIHNFIRKVD RNDELFELYE QEGTQGDVDT
     GDQEVRGQAN LQEDDRVAGE RMMENHQIEM GAFKANGLDV PNGVLRSTMI PSWSLHTTVK
     RVLQSIRTVI FTSKLNLLMP FGPATIVLYY TTDWHGVIFL FSMLGITPLA ERLGYATEQL
     AVYTGPTLGG LLNATFGNAT EMIIAIYALK NGMIRVVQQS LLGSILSNML LVVGCAFFAG
     GIIHRNKDQV FSKATAVVNS GLLLMAVMGL MFPAVLHFTK SEIQQGASEL ALSRFSSCIM
     LVAYASYLYF QLSARNSSYS QIGSEEVPNE DATEEDEEVE ISMWEAIAWL AVLTIWISVL
     SEYLVNAIEG ASDSLHLPVA FISVILLPIV GNAAEHASAI MFAMKDKLIP FCVVVGWMMG
     QKMDLNFQLF ETATLFITVL VVAFMLQDGI ANYLKGLMLV LCYLIVAASF FVHVDPQASD
     DD
//