ID M8AKN5_TRIUA Unreviewed; 712 AA.
AC M8AKN5;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=S-acyltransferase {ECO:0000256|RuleBase:RU079119};
DE EC=2.3.1.225 {ECO:0000256|RuleBase:RU079119};
DE AltName: Full=Palmitoyltransferase {ECO:0000256|RuleBase:RU079119};
GN ORFNames=TRIUR3_29330 {ECO:0000313|EMBL:EMS65580.1};
OS Triticum urartu (Red wild einkorn) (Crithodium urartu).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4572 {ECO:0000313|EMBL:EMS65580.1};
RN [1] {ECO:0000313|EMBL:EMS65580.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23535596; DOI=10.1038/nature11997;
RA Ling H.Q., Zhao S., Liu D., Wang J., Sun H., Zhang C., Fan H., Li D.,
RA Dong L., Tao Y., Gao C., Wu H., Li Y., Cui Y., Guo X., Zheng S., Wang B.,
RA Yu K., Liang Q., Yang W., Lou X., Chen J., Feng M., Jian J., Zhang X.,
RA Luo G., Jiang Y., Liu J., Wang Z., Sha Y., Zhang B., Wu H., Tang D.,
RA Shen Q., Xue P., Zou S., Wang X., Liu X., Wang F., Yang Y., An X., Dong Z.,
RA Zhang K., Zhang X., Luo M.C., Dvorak J., Tong Y., Wang J., Yang H., Li Z.,
RA Wang D., Zhang A., Wang J.;
RT "Draft genome of the wheat A-genome progenitor Triticum urartu.";
RL Nature 496:87-90(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-
CC hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA-
CC COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151;
CC EC=2.3.1.225; Evidence={ECO:0000256|RuleBase:RU079119};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- DOMAIN: The DHHC domain is required for palmitoyltransferase activity.
CC {ECO:0000256|RuleBase:RU079119}.
CC -!- SIMILARITY: Belongs to the DHHC palmitoyltransferase family.
CC {ECO:0000256|RuleBase:RU079119}.
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DR EMBL; KD042450; EMS65580.1; -; Genomic_DNA.
DR AlphaFoldDB; M8AKN5; -.
DR STRING; 4572.M8AKN5; -.
DR eggNOG; KOG0509; Eukaryota.
DR OMA; DVPDCNG; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019706; F:protein-cysteine S-palmitoyltransferase activity; IEA:UniProtKB-EC.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001594; Palmitoyltrfase_DHHC.
DR PANTHER; PTHR24161; ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR24161:SF17; PALMITOYLTRANSFERASE HIP14; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF01529; DHHC; 1.
DR SMART; SM00248; ANK; 4.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 3.
DR PROSITE; PS50216; DHHC; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU079119,
KW ECO:0000313|EMBL:EMS65580.1}; ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW Membrane {ECO:0000256|RuleBase:RU079119};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|RuleBase:RU079119, ECO:0000313|EMBL:EMS65580.1};
KW Transmembrane {ECO:0000256|RuleBase:RU079119};
KW Transmembrane helix {ECO:0000256|RuleBase:RU079119}.
FT TRANSMEM 257..278
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT TRANSMEM 284..305
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT TRANSMEM 393..417
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT TRANSMEM 437..459
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT DOMAIN 348..475
FT /note="Palmitoyltransferase DHHC"
FT /evidence="ECO:0000259|Pfam:PF01529"
SQ SEQUENCE 712 AA; 79987 MW; 234EBE9555D48932 CRC64;
MEGCLLLLQF NCLAIQFDSW PALISPQFRS RDHGADVNAI DHTGQTALHW SAVRGHIQVA
ELLLKEGAKV DAADLYGYQT THVAAQYGQT AFLYHIISKW NADPDVPDND GRSPLHWAAY
KGFADSIRLL LFLGAYRGRQ DKEGMYSLFY KPSYHLKMNH ESMNSPYYWF LWELGCTPLH
WAAIRGNMES CTVLVQVGKK EDLMVQDNTG LTPAQLAADK SHRQVAFYLG NARKVHERGC
GGNNYFGKLS KLGLAPVLWC IIIGLIVAYI HSVIAGQYNS NMTLLFGFFS WLGVFLAIAG
LVMFYRCSRK DPGYINKNIR DSQTQRDDEP LLKRGLDNPE LLAGNWSQLC ITCKIVRPIR
SKHCSTCDRC VEQFDHHCPW VSNCIGKKNK WEFFMFLILE VSAMIITAAT AVIRVAGDPG
SPASFGGWLN YSAMNHPWVV SFVIMDLFLF FGVITLTVVQ ASQISGNITT NEMANAMRYS
YLRGPGGRFR NPFDHGVRKN CSDFFLKGYN EDIEKVEQTS HPDEEMAIIH MTRGAVSQNG
ESVPLHANGA DHVCADSQAN SKSHRQVSSS KCCDHTKKTD KTPLGLGVDS SDAVLFWKIQ
LYIGRAVNYE CCSSERNVGF ITTFYVNMNR IRVSASVTYE TEVGDDLIEE VLQAVNNCKI
LDGWNNTSVV MIPKLRKSKL PNPQPGIKLD HRRPMRVNRI GSMDKSHEMM LP
//
