ID   M9LQ92_PSEA3            Unreviewed;      1359 AA.
AC   M9LQ92;
DT   29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2013, sequence version 1.
DT   27-MAR-2024, entry version 45.
DE   RecName: Full=DH domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=PANT_12c00024 {ECO:0000313|EMBL:GAC74551.1};
OS   Pseudozyma antarctica (strain T-34) (Yeast) (Candida antarctica).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC   Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Moesziomyces.
OX   NCBI_TaxID=1151754 {ECO:0000313|EMBL:GAC74551.1, ECO:0000313|Proteomes:UP000011976};
RN   [1] {ECO:0000313|Proteomes:UP000011976}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=T-34 {ECO:0000313|Proteomes:UP000011976};
RX   PubMed=23558529; DOI=10.1128/genomea.00064-13;
RA   Morita T., Koike H., Koyama Y., Hagiwara H., Ito E., Fukuoka T., Imura T.,
RA   Machida M., Kitamoto D.;
RT   "Genome sequence of the basidiomycetous yeast Pseudozyma antarctica T-34, a
RT   producer of the glycolipid biosurfactants mannosylerythritol lipids.";
RL   Genome Announc. 1:E0006413-E0006413(2013).
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DR   EMBL; DF196778; GAC74551.1; -; Genomic_DNA.
DR   STRING; 1151754.M9LQ92; -.
DR   OrthoDB; 24739at2759; -.
DR   Proteomes; UP000011976; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR   PANTHER; PTHR12673:SF159; RAC GUANINE NUCLEOTIDE EXCHANGE FACTOR JJ; 1.
DR   Pfam; PF00621; RhoGEF; 2.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000011976}.
FT   DOMAIN          348..641
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          674..780
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          1..80
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          125..157
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          223..280
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          542..577
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1172..1195
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1290..1359
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        8..62
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        223..278
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1180..1194
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1324..1347
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1359 AA;  143260 MW;  C976266C1F26CB87 CRC64;
     MHQFEHSAAG HASSSRTPAM PRISTALAFP PSSTSSSSPD TAGSASLASP ATSTPRATSP
     ENKPSESTKH DAPPHSPVPA CMAGLALQVQ SAVSRNVTGP LVQVLTDAQE ASALHCAQHD
     ATRALSTEAS ASSSSSSSSS GSGSSASSRT APMPGQTSAA SRYVSALSSP DLVPCDAAAQ
     SSAQALMGTS AQNSDDLATQ LHSVHAADAA HTSSSPIVAP LLQQRDSGSS DGSGSGTEAS
     LAQSDICRTP STSTTGSSHA GSLDTAISSV PSGTEFESNY KSHVEEQSAD TLRVSVAAYD
     PSIAPSQASP ISLSSEADNA LLDYSPLPHD ASAGASLVEA KFATAKVRRY AALLELIDTE
     RNYADDLATL VLVFFDNLCM MPFFNDQPAR QALVMRNSQD LLRTHQKLSA KLDAILVDLG
     LRKSGQRHAD DQKTELEKAL SPQADEAVVR AAKLFNQMMP QLQSYKAFCS RHGEALALIR
     EAEKRHADWD AFERHCADIL RLTQRAHKHT SSRPPSGATT PSVWATNSPA SYFIPIASSS
     ATPSPNLASG STSTLTAATT ASGSNPGSAA ATPATAPSVM RQNSSRLLFR DFLIKPIQRL
     CLYPLVLQTL QKHSSATDDS VDELALAISL MREVADQVDE AGKRRESELR ADLISSRIEP
     NQSVTLSFLK SLGDCQLSGT LDVLHHHRLL NPLTAPLRFK YFGVFVYHSF LLMVKVRKNS
     TYESRHWFPL WAARLSNVED EQNLIPNSFR LSVRDHHFEL AASNAKERQL WIDMLSLAIS
     RATFSPPGSQ AAFPCSLFFG DAPDGESLEA SEAPTPNASR PAEFQGYFET AKAGTVDPLM
     EFLAMHAAGA AQATGTNNRG QRASSSGPWM PTEILLRHAS SNSRAIVDRG MVLSDAVISA
     RIARDGGALS TLYAASGSGI GSAVGSSLGL SRLSAKDTAT VKIQRRKSCA GLLENADAED
     DPNNLVFTAT LVQPGSRSRS STRGQLDAVS EREGWKSSLL KKANRVRPTS IFAPNGLSVN
     TDGLASPVWG PGSVSTPSSP ITAGRDLLVH EFGSFGITGS VPLSPTTPTS HVAGIGGAEL
     ASHSLTSSPN SGSNSAANST VNLRAQGYAM PTRSRTSLYS MKDSLTMTFG KRVRTRSVQG
     GVGEADPMHE FGVGSALSSA AASPMASNVS LPHGEVVDSS SRRPSADELY RGQKARSRTN
     SISSVTGSIR RVFTSASLAT LSHKRGQSEA VKVGGSVQSE RQLAETVVEE EAAKTGGTLR
     RSRTMLDYSR SWFRGSATSV VERVNAQAVA PATSPTASPM ASPGQEQGPR GVGSKGDGMR
     RSSDTHVGTV NAQPSRARQS SKVYNKLKFL HNNKLSPMQ
//