ID M9LRS5_PSEA3 Unreviewed; 614 AA.
AC M9LRS5;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=3-hydroxyisobutyryl-CoA hydrolase {ECO:0000256|ARBA:ARBA00011915};
DE EC=3.1.2.4 {ECO:0000256|ARBA:ARBA00011915};
GN ORFNames=PANT_19d00024 {ECO:0000313|EMBL:GAC75936.1};
OS Pseudozyma antarctica (strain T-34) (Yeast) (Candida antarctica).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Moesziomyces.
OX NCBI_TaxID=1151754 {ECO:0000313|EMBL:GAC75936.1, ECO:0000313|Proteomes:UP000011976};
RN [1] {ECO:0000313|Proteomes:UP000011976}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T-34 {ECO:0000313|Proteomes:UP000011976};
RX PubMed=23558529; DOI=10.1128/genomea.00064-13;
RA Morita T., Koike H., Koyama Y., Hagiwara H., Ito E., Fukuoka T., Imura T.,
RA Machida M., Kitamoto D.;
RT "Genome sequence of the basidiomycetous yeast Pseudozyma antarctica T-34, a
RT producer of the glycolipid biosurfactants mannosylerythritol lipids.";
RL Genome Announc. 1:E0006413-E0006413(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-
CC methylpropanoate + CoA + H(+); Xref=Rhea:RHEA:20888,
CC ChEBI:CHEBI:11805, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57340; EC=3.1.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001709};
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DR EMBL; DF196785; GAC75936.1; -; Genomic_DNA.
DR AlphaFoldDB; M9LRS5; -.
DR STRING; 1151754.M9LRS5; -.
DR OrthoDB; 3639304at2759; -.
DR Proteomes; UP000011976; Unassembled WGS sequence.
DR GO; GO:0003860; F:3-hydroxyisobutyryl-CoA hydrolase activity; IEA:InterPro.
DR CDD; cd06558; crotonase-like; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR045004; ECH_dom.
DR InterPro; IPR018376; Enoyl-CoA_hyd/isom_CS.
DR InterPro; IPR032259; HIBYL-CoA-H.
DR PANTHER; PTHR43176:SF3; 3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43176; 3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED; 1.
DR Pfam; PF16113; ECH_2; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR PROSITE; PS00166; ENOYL_COA_HYDRATASE; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000011976}.
FT DOMAIN 101..189
FT /note="Enoyl-CoA hydratase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF16113"
FT DOMAIN 218..502
FT /note="Enoyl-CoA hydratase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF16113"
SQ SEQUENCE 614 AA; 65579 MW; 3DA83933C6F80540 CRC64;
MRMSRLLRTT TSSLLARPQA TTAAARLAPS LPALPALSAA SRTMTRVKTA NARLSQVSRQ
FSSSTSMSAS APKSGAGVGA GSNAALDDNK LVKLLSEGGL RTILLNREKA LNALNQEMVD
LIDAALDECI QAAACNVILL RGTGRALCSG GDVLAVVKAA DSADAKVRNT ALDFFQSEFQ
LDYKIARLGE AANAHSAGKG AEDARTLTKS KGGELKKPKT FVSVMDGITM GGGVGLSVHA
PFRVATERTM FAMPETGIGY FPDVGVTRVL ARLDGRIGQY LGMTGARISG EEAYLVGLAT
HYVASGNIDA LAHRLSTLPA ESALNPSLVS QALHEFDADP LAANETLAKS AFFGDRRIAL
DYVFGQLSCE SIFSCLDEIA AGKTDSQAAV ELAELGLAHI TPEVQAWAQQ TLKDLKTKSP
RALKITHQAI LEARRFDVEE AFRFDMRLAT AFCDFSIGRD FYTGVTHVLE RDPATGKRRT
GIAAWDPPSL DKVSDTQIRA QFFSDLDTAR KAGLQMDVPE LPSVPAPATS KEARQARDSL
LRGKGPLRWE QSHNVFALPS EAECAALLEG NHPAAAAVTP DSAELIDCLK RHKGHLPGLE
FKVADWIKRS HRSA
//
