ID   M9LYB5_PSEA3            Unreviewed;       852 AA.
AC   M9LYB5;
DT   29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2013, sequence version 1.
DT   27-MAR-2024, entry version 39.
DE   SubName: Full=Transferrin receptor and related proteins {ECO:0000313|EMBL:GAC72045.1};
GN   ORFNames=PANT_6d00044 {ECO:0000313|EMBL:GAC72045.1};
OS   Pseudozyma antarctica (strain T-34) (Yeast) (Candida antarctica).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC   Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Moesziomyces.
OX   NCBI_TaxID=1151754 {ECO:0000313|EMBL:GAC72045.1, ECO:0000313|Proteomes:UP000011976};
RN   [1] {ECO:0000313|Proteomes:UP000011976}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=T-34 {ECO:0000313|Proteomes:UP000011976};
RX   PubMed=23558529; DOI=10.1128/genomea.00064-13;
RA   Morita T., Koike H., Koyama Y., Hagiwara H., Ito E., Fukuoka T., Imura T.,
RA   Machida M., Kitamoto D.;
RT   "Genome sequence of the basidiomycetous yeast Pseudozyma antarctica T-34, a
RT   producer of the glycolipid biosurfactants mannosylerythritol lipids.";
RL   Genome Announc. 1:E0006413-E0006413(2013).
CC   -!- SIMILARITY: Belongs to the peptidase M28 family. M28B subfamily.
CC       {ECO:0000256|ARBA:ARBA00005634}.
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DR   EMBL; DF196772; GAC72045.1; -; Genomic_DNA.
DR   AlphaFoldDB; M9LYB5; -.
DR   STRING; 1151754.M9LYB5; -.
DR   OrthoDB; 67337at2759; -.
DR   Proteomes; UP000011976; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd08022; M28_PSMA_like; 1.
DR   CDD; cd02121; PA_GCPII_like; 1.
DR   Gene3D; 3.50.30.30; -; 1.
DR   Gene3D; 1.20.930.40; Transferrin receptor-like, dimerisation domain; 1.
DR   Gene3D; 3.40.630.10; Zn peptidases; 1.
DR   InterPro; IPR046450; PA_dom_sf.
DR   InterPro; IPR003137; PA_domain.
DR   InterPro; IPR007484; Peptidase_M28.
DR   InterPro; IPR039373; Peptidase_M28B.
DR   InterPro; IPR007365; TFR-like_dimer_dom.
DR   InterPro; IPR036757; TFR-like_dimer_dom_sf.
DR   PANTHER; PTHR10404:SF46; GLUTAMATE CARBOXYPEPTIDASE 2 HOMOLOG; 1.
DR   PANTHER; PTHR10404; N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE; 1.
DR   Pfam; PF02225; PA; 1.
DR   Pfam; PF04389; Peptidase_M28; 1.
DR   Pfam; PF04253; TFR_dimer; 1.
DR   SUPFAM; SSF52025; PA domain; 1.
DR   SUPFAM; SSF47672; Transferrin receptor-like dimerisation domain; 1.
DR   SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius}; Receptor {ECO:0000313|EMBL:GAC72045.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011976};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        56..74
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          280..359
FT                   /note="PA"
FT                   /evidence="ECO:0000259|Pfam:PF02225"
FT   DOMAIN          470..649
FT                   /note="Peptidase M28"
FT                   /evidence="ECO:0000259|Pfam:PF04389"
FT   DOMAIN          722..850
FT                   /note="Transferrin receptor-like dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF04253"
FT   REGION          371..401
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   852 AA;  93189 MW;  10F8DCB1FFBA9FA9 CRC64;
     MAPFQHFGTE ALASTPLMLD NDYAEEKAAP SDSKPAGPIQ VKIHVPPTGK TYSFRGFRAL
     IALVLLLAVP FFVVKSTAEF VSDALIRLTR PCPHAASSVR GYAEHLRSVG FFSAEANADS
     LHRPDPEQRW RQWFDKLEND FLAVPSADSA RDALKRYTNV THYAGSEGDY NSALQILEEW
     GTLVGAPLTD DLKHLVFDAG SPQSQAYLRG EGDKNGVRAW TDTYAVWLNY PVNSSLTLAK
     PDALDAPYWS AKLQEDVLEK DPTSSRGVPF FHGYSASGSV SGQVVFAGMG RKQDFADLAA
     RGIDVKGKIV LVDYGSNFRG LKVRAAQEAG AVGVIIYTDT IEDGEVTEAN GYKAYPDGPA
     RNPSAIQRGS VQGLSFYPGD PSTPGKPSYR NATRLEPQDA DSLPKIPSLP LSYTEAKVLL
     AAMKGKGIRA SDVNDRLAGA IDGVEYWTGP SDDVVHLENF VDLQVRDIWN TYAVLPGHIT
     DEVVVLGNHR DAWTFGAADP NSGTAAFHEA IKGLGQLYRS GWKPMRTIIF ASWDAEEYGL
     VGSTEFGEDY AKWIQDHVVA YHNVDVSVSG SVIQSSSSPS LSRFVQDAAA KVDDPNTSGK
     IKLDAFNPLG SGSDYTVFLQ HLGVASTDLG YKRAAKDPVY MYHSNYDSFF WMDNFGDPGF
     RRHEAAAKIV GLMAIETSTQ LFAPMNVADY AHELTKYLAN IEKLAAKELG IPLGARHPAW
     LGELRIAIHS LGVAAKGFEK NKAFLRKKLV HLAKKVHKQG GHDKEIRKVL AQIRRVNQKL
     QTFEQGFISN DGLKGRAWYK HLGTAPGRWL GYGATTFPGV TEAITLDKGS GLQAEAHRLT
     THIKRLSHHL NH
//