ID   M9M7Y6_PSEA3            Unreviewed;       822 AA.
AC   M9M7Y6;
DT   29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2013, sequence version 1.
DT   27-MAR-2024, entry version 40.
DE   RecName: Full=Translation initiation factor eIF2B subunit epsilon {ECO:0000256|ARBA:ARBA00044144};
DE   AltName: Full=eIF2B GDP-GTP exchange factor subunit epsilon {ECO:0000256|ARBA:ARBA00044345};
GN   ORFNames=PANT_26c00012 {ECO:0000313|EMBL:GAC77355.1};
OS   Pseudozyma antarctica (strain T-34) (Yeast) (Candida antarctica).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC   Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Moesziomyces.
OX   NCBI_TaxID=1151754 {ECO:0000313|EMBL:GAC77355.1, ECO:0000313|Proteomes:UP000011976};
RN   [1] {ECO:0000313|Proteomes:UP000011976}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=T-34 {ECO:0000313|Proteomes:UP000011976};
RX   PubMed=23558529; DOI=10.1128/genomea.00064-13;
RA   Morita T., Koike H., Koyama Y., Hagiwara H., Ito E., Fukuoka T., Imura T.,
RA   Machida M., Kitamoto D.;
RT   "Genome sequence of the basidiomycetous yeast Pseudozyma antarctica T-34, a
RT   producer of the glycolipid biosurfactants mannosylerythritol lipids.";
RL   Genome Announc. 1:E0006413-E0006413(2013).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000256|ARBA:ARBA00004514}.
CC   -!- SIMILARITY: Belongs to the eIF-2B gamma/epsilon subunits family.
CC       {ECO:0000256|ARBA:ARBA00007878}.
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DR   EMBL; DF196792; GAC77355.1; -; Genomic_DNA.
DR   AlphaFoldDB; M9M7Y6; -.
DR   STRING; 1151754.M9M7Y6; -.
DR   OrthoDB; 5474157at2759; -.
DR   Proteomes; UP000011976; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0031369; F:translation initiation factor binding; IEA:InterPro.
DR   CDD; cd04197; eIF-2B_epsilon_N; 1.
DR   CDD; cd11558; W2_eIF2B_epsilon; 1.
DR   Gene3D; 1.25.40.180; -; 1.
DR   Gene3D; 2.160.10.10; Hexapeptide repeat proteins; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR035543; eIF-2B_epsilon_N.
DR   InterPro; IPR005835; NTP_transferase_dom.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   InterPro; IPR003307; W2_domain.
DR   InterPro; IPR044123; W2_eIF2B_epsilon.
DR   PANTHER; PTHR45887; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON; 1.
DR   PANTHER; PTHR45887:SF1; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON; 1.
DR   Pfam; PF00483; NTP_transferase; 1.
DR   Pfam; PF02020; W2; 1.
DR   SMART; SM00515; eIF5C; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR   PROSITE; PS51363; W2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Initiation factor {ECO:0000313|EMBL:GAC77355.1};
KW   Protein biosynthesis {ECO:0000313|EMBL:GAC77355.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011976}.
FT   DOMAIN          644..813
FT                   /note="W2"
FT                   /evidence="ECO:0000259|PROSITE:PS51363"
FT   REGION          1..39
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          486..514
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          541..560
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          588..634
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        546..560
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        596..623
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   822 AA;  89504 MW;  8920EDDDACDB2354 CRC64;
     MPPKSSAKGG GSGGGGKSGN AAASSKAKSH QNKEEDLQRE PLQAVVLADA FSKRLDPLTT
     DKPACLLPLC NVPLLDWTLE NLALAEVEEI FILASRHSDQ IKKHLATTPA RYSLPKITVI
     ATPDAQSLGD VMRELDSKQI IRSDFILIHA DSVASMDLAS IVDAHKRRRK KDKDAIMTIC
     TMPVGKRSRI RTPGNLSLFF LEPHTSQLVH YAPVRAAPRL RTTSLPLEVF DEDAAATTHS
     LARAAEVDVR NDLVDCGIDI CSADVPPLFS ENFDYQTLRR DFVLGILTSD LLDSKIFVHV
     APTGPPASAV QIASSSFPEV VGTSKYGRGY AARVKSPADY DAISKDVMGQ WTYPLGPAGY
     LPGGQRYSPR SGLRFLGDNV VLSRTCQLGP HTLVGSQSEI GDKASLYQSM LGSSVRVGSR
     TTISGSYVWT GSVIGSGCSI ERSIVGERVT ILDGVKLNKG CIIAEGCTVG PNVELPAFSR
     VGNKKEKFDD DFDSDSEDDE QLDTARTGAS ASNAAKEAFS KGLGAKGVGF LWRALGEKPV
     RAEDDMDSEA SDEDEDEVDE IERSHNLRLM RLGADLEDME LDDTLSDISS VGIGRDSDDD
     DDDDGSGAQT DNSMSDDDDD DMLGGSMMLS IGDGETNVEK QAAVKRLDEF RTEATASLER
     AFEENHTVDD AAIELKTLRM ASNVPLKEVR KTVIGFILTK CEPDQPKQML AVLDKWCPLI
     SVVAVDDQIE ALATVQNFCA TQPKYYKIFI PLLKKFYNDD IISEENIVGW WKSPLSRKTD
     ADIGGDKNLQ LRKAAEEVIR YILESQESTD EDDDDDEDDD DE
//