ID M9MBL3_PSEA3 Unreviewed; 2622 AA.
AC M9MBL3;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 08-NOV-2023, entry version 58.
DE SubName: Full=Predicted Rho GTPase-activating protein {ECO:0000313|EMBL:GAC72613.1};
GN ORFNames=PANT_7d00189 {ECO:0000313|EMBL:GAC72613.1};
OS Pseudozyma antarctica (strain T-34) (Yeast) (Candida antarctica).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Moesziomyces.
OX NCBI_TaxID=1151754 {ECO:0000313|EMBL:GAC72613.1, ECO:0000313|Proteomes:UP000011976};
RN [1] {ECO:0000313|Proteomes:UP000011976}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T-34 {ECO:0000313|Proteomes:UP000011976};
RX PubMed=23558529; DOI=10.1128/genomea.00064-13;
RA Morita T., Koike H., Koyama Y., Hagiwara H., Ito E., Fukuoka T., Imura T.,
RA Machida M., Kitamoto D.;
RT "Genome sequence of the basidiomycetous yeast Pseudozyma antarctica T-34, a
RT producer of the glycolipid biosurfactants mannosylerythritol lipids.";
RL Genome Announc. 1:E0006413-E0006413(2013).
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DR EMBL; DF196773; GAC72613.1; -; Genomic_DNA.
DR STRING; 1151754.M9MBL3; -.
DR OrthoDB; 1359393at2759; -.
DR Proteomes; UP000011976; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd06224; REM; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR047165; RHG17/44/SH3BP1-like.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR14130; 3BP-1 RELATED RHOGAP; 1.
DR PANTHER; PTHR14130:SF14; RHO GTPASE-ACTIVATING PROTEIN 92B; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 2.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000011976}.
FT DOMAIN 888..1167
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT DOMAIN 1356..1539
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 2125..2318
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 280..303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 318..374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 390..449
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 597..659
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1901..1937
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1952..1992
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2319..2441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2464..2565
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..117
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..194
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 219..239
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 323..347
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 390..428
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1913..1931
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1953..1989
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2322..2340
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2377..2401
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2468..2491
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2503..2525
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2535..2549
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2622 AA; 282685 MW; EDE63C4AA56AA37C CRC64;
MPTPSSQSGP HPGSARAQNQ HAQQPYYPQA QPLHHQHQHL QRYQQQHQQQ PSPPASSSSQ
QSQAHHDRAP PSQPIGRSQS AFNFLLNKAK APFSSSSSSS TLNASTSLSS LSVHQEDPFD
DTTNHIQYHR QLQNDHAFPQ APPSAPPARR TASGGIEKTA RPHPFAHDAS QPSKSTGAPF
SRPSYSSEEP QNAVASPTKR GFFGGIGRDR KASTASINKP APHKPNFSHS PLSKPQRTDP
TMAANYAHFS KSQSDLHSRA DYPSPTNMTV ELPRLPAVYH NSNTAQPPID RNRYLRSPSP
AMNFSRSVDD LSIAEQQPAS PYPISPAHGQ SSSSLATAAT STSPGTWGEH GIPVPQPDWR
PSDMGTLASP THQSAASFQR FKPGHNKLDS VASQLQPSSG SVHSPPHNWS GMSPPQYSYM
QSSAAPSSAR ADAKHARKAS KLMGKDSSAR GAVATSLAAS LGLTHLGAAS AAAVPPLSIL
TTAEPVPLPP GAAFQGFLAR NANISLTLAQ LSGHDHGKGK DKEKDVTKGW KPYRVVLQDG
RLCFYKPPSN ISDDVKALFP TGIVRGVPDT PASSASISSL TADQLVRSGL SKQDLLSATS
STAEMTSPLA SPSLRPRLPS ARPNKSATTP SEVPTTPVAA PPPAEADAPR HQSWLKPGKH
PNLLLVDTVD APPAWADRIQ AGTSEALAHE FVHATQFPTE QAEAQASRRS ILPSPLASGS
RAAASSAESA VESFVVAVLA NASSPAKDAP QDANKQISTF FLDVVKQAEE LTSAGTDISQ
SISASLPSLA SRLRTLLDVA TRAGLFGILT GETLQKLAVL VSMDIDELDD KMQVYTSPIL
SLSDARSPEQ PRDWIARLAE KEAASAREDL RKLRSSLELS DDLLLQLEPL EIAQQIQAFH
VDALRRLVIS GTSFLDLLHP TTTDADSIAA LSFDSLSPHP LTTLALSHLL KSSSSAQDAP
NAAQNGARHR ASVLRHWIAI ASYLLSLGDV AGWMAVCAAL CSRAVTRLEQ TWRYLAEGDR
VLVAEEWAPI LSSLSWTEGL AVHVRPRFVG DGTQSFTTSP DGTKLAVVPY LGSAFYRTLR
QPNNPSTSPS GMLSMSNSSS AEDAAHLWVS VNEWRSAWQG EPSLTLAAHS EPVEEYQAAL
QLLFQNSNTP VSTMEYNMER SFQLEPKALG NVDAGSLDAR ERLSLPSSAD ADLPLAPLLF
PQPLPLLSLL NMSQIKASLG RRNDPRANQI HDPQATITSR SITRPSLAGS PLARASAFSP
PLGRSSRNAA FSGVEWSTIS APTKWDDASN GAVNIGNELV LRLIQEANLS LPGSPMTSKR
FSQDFGRASR PLSQVSKRSS LPASNRSSVI DIVVPVQVVV KAATLDRMID LLVMGVQHIN
VPPISSPMDG PEQQSAPQRK TRLVMDMESY RTTFLATFRS LCSAPELFEQ LQKRFSTAIM
ASKELAGADE FRSSSQFPSW IGVIPAGSQA EPTDWEMVYR IRMGVVLTLR LWIDRFPQDF
VDDDDLYHLA LNFLRHPGME VTTEDPDQQK VVHALAQLRS MFGSRIMGAN ARQEERSYAT
NMAVQISDSR QQADFDFDRA SAAELVEYLE SIATVFFDKI VDRDLLVVSE IFEKFAIQPT
AWYTVKSAGT ASGEEDKPIT NMYTLLDVLR APGGTNADAS KDSTASLRLR MPSAIHDALA
AQSLFRGWIA IHIVESGIGL ERRQERLSKL LDALWLCRAR MLKLRNDEMT ASANAQAGNV
GPIADTSLPF REPTIGSFVE SAIVNTLGSS ESRIFLRAWQ GVAAARGGRG DGIDDLMPKQ
VDADLRSAVD MAGTPDIGWI LACLAEAATR APSVPTSTSD VELIDFEKRR TMWALIDGAV
RVRPACSLPD LVDVAGARLR LMQSALNRVI WDRRAFREEA AKEMRNAPPV RSDAKLRTTT
SSKALSGLSK QQQEKLRRDR AALEMLKSLP SAPPISSRVS SMPSSRARAS NVSSTAFPSM
PQSSDKATMV QAPPPDKATI RARRMTALFK GAVRPLISLD KPNEPSKPTA ELMRLTPLQK
PSLVAGLGGA RVSVWNNTQR SFVFHLTSQE GAKYLLQTTN AADLAEWISQ IERASKEYAG
PQLLDARKGG VPSKTRAGPA PLYARPLAEL AEREGHSVPT AVERMFAEVE ARGLREQGIY
RISGSKSAVE NLRTAWDQQP AESIDLSTGE FSDVHTIAGA IKAWLRELPE PLITFDSYDA
LIATNAMEND DRLYAMRDII WKMPKCHFDV LRRTAEHLAR VVEEGEINKM LAHNVALVFG
TSLLNPPPGP SSVAIGFGNL GKAANVVKTI VTMHEWLFEP EPEPEPEPEP EPEAGPEEEA
EAEEGQRLGA QQNADIEQAD PGSASATEAG VEEASSPVES INATRLRGAS ISSSQDSQPG
LSKDVPVLAT RQDEEQAQSD EEEASTLTEL APRPRRGGRA RPLTIVGLDG LAALGANEDI
AKVLESGTTP NAEASVGEDG TSESQPSQAA PRIVLSGAGD ESDREADGDE GSESGDDDDD
SHEQDAVADA TEVDSEAARV QEKEGHADEA WGAAASARPR KTRSTYRDSV FTSYSIYADC
FDNMRLESQS SAASMVKRQS MHLLNSPPVA QEAVTGDAAV TR
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