ID M9MBY8_PSEA3 Unreviewed; 809 AA.
AC M9MBY8;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE RecName: Full=ATP-dependent DNA helicase II subunit 1 {ECO:0000256|ARBA:ARBA00021796};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
DE AltName: Full=ATP-dependent DNA helicase II subunit Ku70 {ECO:0000256|ARBA:ARBA00031811};
GN ORFNames=PANT_2c00032 {ECO:0000313|EMBL:GAC71272.1};
OS Pseudozyma antarctica (strain T-34) (Yeast) (Candida antarctica).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Moesziomyces.
OX NCBI_TaxID=1151754 {ECO:0000313|EMBL:GAC71272.1, ECO:0000313|Proteomes:UP000011976};
RN [1] {ECO:0000313|Proteomes:UP000011976}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T-34 {ECO:0000313|Proteomes:UP000011976};
RX PubMed=23558529; DOI=10.1128/genomea.00064-13;
RA Morita T., Koike H., Koyama Y., Hagiwara H., Ito E., Fukuoka T., Imura T.,
RA Machida M., Kitamoto D.;
RT "Genome sequence of the basidiomycetous yeast Pseudozyma antarctica T-34, a
RT producer of the glycolipid biosurfactants mannosylerythritol lipids.";
RL Genome Announc. 1:E0006413-E0006413(2013).
CC -!- SUBCELLULAR LOCATION: Chromosome, telomere
CC {ECO:0000256|ARBA:ARBA00004574}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ku70 family.
CC {ECO:0000256|ARBA:ARBA00005240}.
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DR EMBL; DF196768; GAC71272.1; -; Genomic_DNA.
DR AlphaFoldDB; M9MBY8; -.
DR STRING; 1151754.M9MBY8; -.
DR OrthoDB; 21093at2759; -.
DR Proteomes; UP000011976; Unassembled WGS sequence.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00788; KU70; 1.
DR Gene3D; 1.10.1600.10; -; 1.
DR Gene3D; 2.40.290.10; -; 1.
DR Gene3D; 4.10.970.10; Ku70, bridge and pillars; 1.
DR Gene3D; 1.10.720.30; SAP domain; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR006164; Ku70/Ku80_beta-barrel_dom.
DR InterPro; IPR027388; Ku70_bridge/pillars_dom_sf.
DR InterPro; IPR047087; KU70_core_dom.
DR InterPro; IPR005160; Ku_C.
DR InterPro; IPR005161; Ku_N.
DR InterPro; IPR003034; SAP_dom.
DR InterPro; IPR036361; SAP_dom_sf.
DR InterPro; IPR016194; SPOC-like_C_dom_sf.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR12604; KU AUTOANTIGEN DNA HELICASE; 1.
DR PANTHER; PTHR12604:SF2; X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 6; 1.
DR Pfam; PF02735; Ku; 1.
DR Pfam; PF03730; Ku_C; 1.
DR Pfam; PF03731; Ku_N; 1.
DR Pfam; PF02037; SAP; 1.
DR SMART; SM00559; Ku78; 1.
DR SMART; SM00513; SAP; 1.
DR SUPFAM; SSF68906; SAP domain; 1.
DR SUPFAM; SSF100939; SPOC domain-like; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50800; SAP; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000313|EMBL:GAC71272.1};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Kinase {ECO:0000313|EMBL:GAC71272.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000011976};
KW Telomere {ECO:0000256|ARBA:ARBA00022895};
KW Transferase {ECO:0000313|EMBL:GAC71272.1}.
FT DOMAIN 769..803
FT /note="SAP"
FT /evidence="ECO:0000259|PROSITE:PS50800"
SQ SEQUENCE 809 AA; 90474 MW; F87C44A2C6D44C49 CRC64;
MHQRGTKDGG RSIRTGIAAA PHIHSWARSN RFTPTKSRPT LPKRARAKIP TDANLRKRLE
SGSVASTRTK GCLNPERLLP VSPLACSRPP SRTLPTMPKA YFVNKREAAR AFNSDDDDDD
DELEQLDLDA TYQKDMVLFC IDAGESMHRI DPATNTSPLY SALKAAASLM QKKLISSPHD
HVGVLIFNCA DTLFRSAKPG EYYKGSYELQ SVRQVNVPDT YNLKALLSRA ATDPKHLRTV
LPPANKQMRI DWALANAGVA MVAAANAGSK RVFWITDNDD PHPMSSDPKA TKARRACLDK
MNEFRKIGVR IEPFFINPTD GAASDEASTS DLSRGFEVNR FYADVFAQYD DDLEEAEARS
QPRLPAGFGK TAAEQLKGQE PRRSLWDSAV RFQELEDDIA TRETPKRVVF NIRFELAALD
APTADTQTQK QGSAAEEQLP QARMRGRKWQ IGIKGYSLVS RTTKGNPVKV IVDDDCGELK
EVVTHQHYID ANSGKPLSKE QVIPAFQFGN SSSLRGQVTF TPQELKSIKS FGMLPCLKLI
GFRDRDDLLR FEWNVKHAYF IYPSDVEWKG SKKTFTALLN SMVSKGKVGL GLFMPRQNVV
PVFVAIVPQQ EELTEEGQQL APPGMHLITL PYADDVRDIP TNLLHTEDAK DAQVDRAVAF
IERYQKKQPF NPDHYPNPAL NHHYAVLMAT AFQEEQPAGP TDLTVPQYAT IRKRTAHLIQ
EWHASIDEDP RLAMVAEGSS KQAKTSTGVR KTSFEDDSEI LDLWQKGKLS AYTVAELKSA
CEFYRLDAKG RKADLLVRLD AHIRKQRKG
//
