ID M9MF49_PSEA3 Unreviewed; 1411 AA.
AC M9MF49;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE RecName: Full=Telomerase reverse transcriptase {ECO:0000256|ARBA:ARBA00016182, ECO:0000256|RuleBase:RU365061};
DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493, ECO:0000256|RuleBase:RU365061};
DE AltName: Full=Telomerase catalytic subunit {ECO:0000256|RuleBase:RU365061};
GN ORFNames=PANT_9d00385 {ECO:0000313|EMBL:GAC74017.1};
OS Pseudozyma antarctica (strain T-34) (Yeast) (Candida antarctica).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Moesziomyces.
OX NCBI_TaxID=1151754 {ECO:0000313|EMBL:GAC74017.1, ECO:0000313|Proteomes:UP000011976};
RN [1] {ECO:0000313|Proteomes:UP000011976}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T-34 {ECO:0000313|Proteomes:UP000011976};
RX PubMed=23558529; DOI=10.1128/genomea.00064-13;
RA Morita T., Koike H., Koyama Y., Hagiwara H., Ito E., Fukuoka T., Imura T.,
RA Machida M., Kitamoto D.;
RT "Genome sequence of the basidiomycetous yeast Pseudozyma antarctica T-34, a
RT producer of the glycolipid biosurfactants mannosylerythritol lipids.";
RL Genome Announc. 1:E0006413-E0006413(2013).
CC -!- FUNCTION: Telomerase is a ribonucleoprotein enzyme essential for the
CC replication of chromosome termini in most eukaryotes. It elongates
CC telomeres. It is a reverse transcriptase that adds simple sequence
CC repeats to chromosome ends by copying a template sequence within the
CC RNA component of the enzyme. {ECO:0000256|RuleBase:RU365061}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.49;
CC Evidence={ECO:0000256|ARBA:ARBA00024557,
CC ECO:0000256|RuleBase:RU365061};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU365061}.
CC Chromosome, telomere {ECO:0000256|RuleBase:RU365061}.
CC -!- SIMILARITY: Belongs to the reverse transcriptase family. Telomerase
CC subfamily. {ECO:0000256|ARBA:ARBA00008001,
CC ECO:0000256|RuleBase:RU365061}.
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DR EMBL; DF196775; GAC74017.1; -; Genomic_DNA.
DR STRING; 1151754.M9MF49; -.
DR OrthoDB; 55913at2759; -.
DR Proteomes; UP000011976; Unassembled WGS sequence.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003721; F:telomerase RNA reverse transcriptase activity; IEA:InterPro.
DR CDD; cd01648; TERT; 1.
DR Gene3D; 1.10.132.70; -; 1.
DR Gene3D; 1.10.357.90; -; 1.
DR Gene3D; 3.30.70.2630; -; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR021891; Telomerase_RBD.
DR InterPro; IPR003545; Telomerase_RT.
DR InterPro; IPR049139; TERT_C.
DR PANTHER; PTHR12066; TELOMERASE REVERSE TRANSCRIPTASE; 1.
DR PANTHER; PTHR12066:SF0; TELOMERASE REVERSE TRANSCRIPTASE; 1.
DR Pfam; PF00078; RVT_1; 1.
DR Pfam; PF12009; Telomerase_RBD; 1.
DR Pfam; PF21399; TERT_C; 1.
DR SMART; SM00975; Telomerase_RBD; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW Chromosome {ECO:0000256|ARBA:ARBA00022454, ECO:0000256|RuleBase:RU365061};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842, ECO:0000256|RuleBase:RU365061};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU365061};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU365061};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU365061};
KW Reference proteome {ECO:0000313|Proteomes:UP000011976};
KW RNA-directed DNA polymerase {ECO:0000256|RuleBase:RU365061};
KW Telomere {ECO:0000256|ARBA:ARBA00022895, ECO:0000256|RuleBase:RU365061};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU365061}.
FT DOMAIN 733..1169
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT REGION 362..397
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 518..562
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 772..797
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 951..983
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1346..1368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 362..386
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 537..560
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 773..789
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1411 AA; 157986 MW; D0CCB8C38B183C4A CRC64;
MSMRDRQAGV RCSVLQRHFA EVVPLLTLIH DRFGIDASTS SSRSTPDLSE ERWACLDATV
VGLDQHASDA SQSRSWNAVI SSSATSHHTI YEAVQEAQLQ ILSLTPARGT TAIHGRPTAS
SNILLKGYRR PDDRLESFRI TSTGRPGLIN LFPNSMVTNL VLEKEWHYLF HKIGSERFTW
LLVHTSIFVP LMRNGADGTC FVQLTGPALS EPATLKTTSD EQAHSRVNGV PELGQDRTNL
LAQKQDKTPE PPAEVETDCA AEAAVPDAAR SLKLGKRARG FERTTSRLSA RSAASDADIG
ASAANAGALA RKPSEIVLVR SRMFYARSSR NKAGRVEIGL PSVHVLPRSG CAKELDKVLP
NLTQSSSTGQ HTASNKISLL RKSRPSPDTA NEQKRGYRDA DSIFTARRTR HLAKYVFPRQ
FGLHNVFTGA RDFDTTTQPF RDYTVREAEI KTLGAKRTPK AVRSALPILA KILVRHDRLN
YRALLDRCCP SRVPKGRLTA QERKQIVEDL AEIETLQAGA HHSTARDVAT ERHPRTSGPS
GVLTDSAHTN TPSKGKTTSM TPKLKVELPA PAARKPRYHN YAVPTTGQVA HFAKLAVKSL
LPRDLFGSRH NQNLILDTIG EFVRLRRFES FNLHQIAQSF RFADVDWALP PRASRKRRLS
RHDAEARKKI VLEVLYWLFD GLLIPLLRTT FYVTETAAYR NRVLYFRQDD WHVLSRPVLG
QLKETLFEPL TRAEALAMMS SRKLGYSHVR LLPKETGVRP IVNLRRRSTK QVHNAKKIDQ
EEGKSKSKRA RAAAVPTAKQ RKESLMLGQS INYILQSVFH VLTYEKSRML AASTSRGHTL
GDETEQMDVD MLTSSVFGPN EIYTQLKTFK QSLLPETRGT KASGSSKKPS KTEEKKLYFV
KLDVRCAFDS IDQAKLLGII EQILRKGEDE QTEGYRIHRF AKLMPSAVHE SRSAAAHASG
ANNAGAAGAV PSRAAHPRPS GTKREFVRLA RPDSEHIDFI DLASSLAVSL HDVVFVDNVS
YRYESTSLIL KLLRQHVTEN LIKIGKEFYR QRVGIPQGSS LSTLLCSFFY AGMEAQDPFL
RSLRNGGTSD KKCLLMRYTD DFLLITTSKR QAKQFYNVMR KGHPEYGCFI SPAKTLVNFD
LVDPMMAAEV GPLVQRTYGD EFPWCGLTIN TRDLGVSTDL TRYAATDMRD TLTVEYCRRP
GVALVEKMIQ SMKSRCHILF TDTALNGDDR VYANVYTSFV VAALKFSAYL AELRRFGITF
TAEYLLKAIR RLVTFTSRYI GSRAASATAK LNPTAKGDKN VRLGRCGKRA AAWRVSCTVH
APYVHWLGYT AFLDVLRRQD LSYRPRRRKT ATEEEKDQHS PYHRSMDSDT RRALVKLVDA
CVRRTCSDAS RRRLSSIAAK ALQQAQKSLH I
//
