ID M9MGT9_PSEA3 Unreviewed; 5426 AA.
AC M9MGT9;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=Midasin {ECO:0000256|ARBA:ARBA00017143, ECO:0000256|PIRNR:PIRNR010340};
GN ORFNames=PANT_26d00006 {ECO:0000313|EMBL:GAC77348.1};
OS Pseudozyma antarctica (strain T-34) (Yeast) (Candida antarctica).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Moesziomyces.
OX NCBI_TaxID=1151754 {ECO:0000313|EMBL:GAC77348.1, ECO:0000313|Proteomes:UP000011976};
RN [1] {ECO:0000313|Proteomes:UP000011976}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T-34 {ECO:0000313|Proteomes:UP000011976};
RX PubMed=23558529; DOI=10.1128/genomea.00064-13;
RA Morita T., Koike H., Koyama Y., Hagiwara H., Ito E., Fukuoka T., Imura T.,
RA Machida M., Kitamoto D.;
RT "Genome sequence of the basidiomycetous yeast Pseudozyma antarctica T-34, a
RT producer of the glycolipid biosurfactants mannosylerythritol lipids.";
RL Genome Announc. 1:E0006413-E0006413(2013).
CC -!- FUNCTION: Nuclear chaperone required for maturation and nuclear export
CC of pre-60S ribosome subunits. {ECO:0000256|PIRNR:PIRNR010340}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}. Nucleus, nucleoplasm
CC {ECO:0000256|ARBA:ARBA00004642}.
CC -!- SIMILARITY: Belongs to the midasin family.
CC {ECO:0000256|ARBA:ARBA00007188, ECO:0000256|PIRNR:PIRNR010340}.
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DR EMBL; DF196792; GAC77348.1; -; Genomic_DNA.
DR STRING; 1151754.M9MGT9; -.
DR OrthoDB; 1221059at2759; -.
DR Proteomes; UP000011976; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR CDD; cd00009; AAA; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 6.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR040848; AAA_lid_7.
DR InterPro; IPR011704; ATPase_dyneun-rel_AAA.
DR InterPro; IPR048617; MDN1_AAA_lid_4.
DR InterPro; IPR012099; Midasin.
DR InterPro; IPR041190; Midasin_AAA_lid_5.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR025662; Sigma_54_int_dom_ATP-bd_1.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR48103:SF2; MIDASIN; 1.
DR PANTHER; PTHR48103; MIDASIN-RELATED; 1.
DR Pfam; PF07728; AAA_5; 9.
DR Pfam; PF17865; AAA_lid_5; 1.
DR Pfam; PF17867; AAA_lid_7; 3.
DR Pfam; PF21108; MDN1_4th; 1.
DR PIRSF; PIRSF010340; Midasin; 1.
DR SMART; SM00382; AAA; 6.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 6.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS00675; SIGMA54_INTERACT_1; 2.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR010340};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|PIRNR:PIRNR010340};
KW Initiation factor {ECO:0000313|EMBL:GAC77348.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR010340};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR010340};
KW Protein biosynthesis {ECO:0000313|EMBL:GAC77348.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000011976}.
FT DOMAIN 5184..5328
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 290..310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 886..941
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1920..1939
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4447..5059
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 295..309
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 915..941
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1925..1939
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4483..4505
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4506..4523
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4524..4557
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4562..4637
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4638..4676
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4712..4727
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4728..4754
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4755..4771
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4786..4800
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4839..4853
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4854..4868
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4928..4946
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4947..4962
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4989..5018
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5035..5059
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5426 AA; 591762 MW; 1357F3B9D8438EFD CRC64;
MGLAADSTPS TAQVEAKVAA VSRRSALDLD VHASCSALAE ELSEQSNAVG LGQDVLAGLD
AGQGTASDAL SRVADLLIDP SCTVSVAAQF KPVLLELLAR VLKRIDASNR AHAQATIQIL
HTFALLISIF PEIHDLLSHF LATFASASFV HGITAEQPEL RNQVLLDLLR IASAAPFSLA
DEVGTSYTQW AHSILSASEP SDSLPTRLLA VALFSALQNS SEQARIELQR KCLNLGSTDV
FDQYAVEATA TLAFEPAGIN VWTLEVEEFG RIDRIRGLVM SRQVAFLPHP SDAADTPSAS
ATDASKPRSH ARLSSADLSA EVCCIGSVLL SCSPRSNRES AATRSHDPFV ETEGITPALS
DLAVRLSLNY PILLSGPPSS GKSTLIRHLS QLLKGAESSA AASHLLTIQL GDQSGIDAKQ
LLGSFVSSPT EPGKFEWTEG ALTRAVRQGK WVVLEDIDKA GSEVLSTVAR IVQQLGPTKA
VGLRPIIDLG TRGKVTAGTG FALFATRSIA SSSSSAKKAA ASSIATFLGA SHWSEVTIDA
PSLQDVSTIL TNKSPRLAES QPRFVERLVA TWYKLQRATQ PSTHGAAQAT GTNAGSVRVA
TLRDLIKWSR RVERLLAADQ AMLSDPLTNP VQQEEIFIEA CDIFLGSVPP ASDVLGSGTA
ASSASSTLQI SRSTNGKQVD RYGALVELLA EELGLTSERA WWALKQRIPE LSVRSLDSTT
DAVAMSAAVD SATSAIRVGR CELARRSKAT AKRAMPVSRK FAMTKPSLLL LERLTVATAL
AEPLLLVGET GTGKTTVVQH LASLLGQPMT ALNLSQQTES GDLLGAFKPL DPKLPATELH
DQWSSLFART FSSRRNARFV DAERKAFVAG KWSRLALLWR ESAKMASQRK KGSTKANGTE
AAEESIADPG ADVRPSSASR KKRKTDKGAT EGSPADVDDA RAEAELDREW LDLDEKARAF
GLQHGSKKKN LVFSFVEGPL VKALRQGDWL LLDEINLAAA ETLDSLTGLL QSPTSSITLT
ERGDLEPIPR HPNFRIFACM NPATDVGKKD LPASLRSRFT ELYVPSPDAD REALTAIVDK
YIGEHALGDR GAVMDVAECY TEIRRLAQQH QLADGANQRP HYSIRTLSRA LTFATDIVPQ
YGLRRSLWEG FIMAFTLLLD EASARLVRGI IERHTLSKAK NARSIATYVP PAPEGADDGK
FVQVGPFWLP TGPAPLDAAE DYILTPSVQS KLVGLSRAAL VRRFPVLIQG PTSAGKTSAV
EYLARRTGHR FVRINNHEHT DIQEYIGSYA SDPDSGKLSF QEGLLVKALR RGDWIVLDEL
NLAPTDVLEA LNRLLDDNRE LVIPETGEVV KPHPHFMLFA TQNPPGLYAG RKVLSRAFRN
RFLELHFDDV PRAELETILT NRCKIAPSYS SRIVGVFEEL QKRRQAGRVF ETKQAFVTLR
DLFRWGNREA VGYQQLAENG YMLIAERARR ADDKEIVQEV IEKVMRVKLN VESMYRLEGP
DSEATLARIG TGIGGAIVAA LSQTGIVQTS AFQRLLCLVA TSLRYNEPVL LVGETGAGKT
SVCEVLATAF GRQLHCVNCH QNTDTADLLG GQRPLRNRAA LQRSAAAACI EVLSGLGIAH
ELNAQSKMED VSSFVEAVLS KEQEHFASLE EASRNEARTA LRNAVRSVYQ ATALFEWQDG
PLVQAMRAGD HILLDEISLA DDSVLERLNS VLEPARTLVL AERATSSSHL GSEADLMSSQ
ITGAEGFQVL ATMNPGGDYG KKELSPALRN RFTEIWVPHV DIRSDLVQII NAQLKDASLA
AWTEPIIDFS DWFIHQIGGR DQSGLGLRDL LTWASFMNEI SARSSLDSAL AFAHGASLTI
IDGLGALPAT AAMTASGLEQ LRDRCLAKVA ELIAPHQYDP KMSSLFEVEV SSEKLRIGPF
SVPRGQPDPS TQGSGSFSFG AKTSASNAMR VLRALSVPAK SVLLEGSPGA GKTSLITALA
AAAARPLTRI NLSDQTELVD LFGSDMPLEG GGPGEFAWRD AAFLTAMQQG EWVLLDEMNL
ASQTVLEGLN SCLDHRGTVY VPELGRSFAK HPDFRIFAAQ NPHHQGGGRK GLPKSFLNRF
IKVHIEELDG DDILAISTHL YPNFDTEQLR SMILFNFELH NEVVVKHSFG RIGAPWEFNL
RDLMRWLDLL HTDLGLNKLG DPIEHLASLY VQRFRTASDR RSARDLFKRA FPGAASSEPR
MVTTITANHV RIGHAVMPRE PASELQSHRL ALLQSQLPVL KALIDCVQKK WLSILVGPTG
SGKTSVVRLV AQLAGARLEE FQMNSGTDTM DLIGTFEQFD PSTRTRSALA ALVREAHRLS
EQVAARSHSR YASFLTAQGT LKTALGSSQS SPSSELLLAA LEDVRNATGD VRDEVFRTTL
ENAVAVVTEM TQNTQDAQKS TGRFEWIDGP LLRALQEGHW LMLDNANLCS ASVLDRLNSL
FEPNGCLVIS ERGVVDGKVP VIRPHPNFRV FMCLDPRHGE LSRAMRNRGI EIALLPKTDS
TSHDLDSLAI LSGCTRTQSL IPSRSTQDEL MEAAIQAQLT QRAILTADML PDSKGASQRR
AAAWAASQLP LQNSCLASTA LPLYLAGAGE HGSPAAASLL VRLSSSRALA LALQVFQRCF
PSASGNSLSL LQEVVSSGKT FHPPGLTLRQ DLVNVGRVSQ ELADRLAIDL RYDDNVLDLL
QSHGLPPQML VDLLLVALLH RQEARSVLES ASSKRLNDLS ILERSARLSS SARVHDEDQA
ATAVRNVYPL VVEISDTVVS SVQSQAAASC GSATLRRVAL LMRSADYLQS LCTTSELDFS
SIQILVRFMS NLVREINAGG LDVAAALTET IDLLGGSLTL SSGKALSTIW SLYGADEGMQ
TNLYRLICDE AQLFRSAPSG DLLKSALDIA ATLCVAGKQS ASPSELRDMM QLGWQTLKMI
RSASNKITAE GQDPHARSRA SENAEATLLS MAELSIRTPE CLSDPTNASR MKLVIALLES
HPSPSVQAAA ASNKAALWSL APGSAKSSAL LSDFSWIRRL WPFGSTSGST SGGPADLLRP
SLVHTLLESR FGDRSLSEKS RHDVAVGRMI QTAGALLPAS SPSRAEKLAQ ILVRFVCFVS
ETLCRAALKD SADLKSPVLT GLLTVSDCQS ALTYVLASPD ARLTADTADA LTEWTSFLQS
FSLSEIDASD EEASMALLGR GWIAASLIML RLFLPNVALD PIVARRTMAD FGVFCRTQLE
NALALEVFAE SMVTGGSRNR VTDELRAQME ESRSALSPQG GDDGQAWRKP NLKLLSQLYR
ETSSFLKEVI TAKRVDDLVQ ALLNGHSEQA QQREDSLQAS ILSFGDRLRK TFSELRDMVE
PITASLSQLQ LGLGLVRQAA RIASASEDVK QRGAIVQALS AFPTTRSSSL LRQLDLSGQL
QARSDVSAAL LIVSTASVAY DHTALGIDVL EKRETLRAIS RTYERVFQLW ALDRERAKRE
EEEATSLYKS RKVEESIELD ADAEEREFHA LFPEYGDDVM DAPTTRRAAQ EEQSVGVLLP
SQRFTAVLSA HMAIFGPSRS NAGSDLYHRE RDALVTKLLR KHHRDWSEQI DRTGAAFGLS
AAIDEHLASK QTARDFNFYL DPRPSEIRKA TVIVEELRLR LDALIQDWPE QMVLQHIRDR
CDAVLRLEAA SPVAKMLSAL EQLLTHTEDW EGFASQQTSL QSNRERISAQ IIEWRRLELS
CWAELLKTQA RNFQEELGGW WFRVYEIVIR GTRAASADGP DAFKSHVEQL IDAVDQFVRS
SPLGQFEGRL SLLESFAHFV ERLVRLAPPK QSRGLKEVGV VLKNVTTFFR QFDERISNTL
QSQRAVLEKD ILGFIKLASW KDINVHALKQ SAQKTHRQLH KTLRKFRDIL RQPVDPMLAA
HLDALTRKEI PPVSLDMIRL QAASETSSKV SDAWAKAVLI ASLEDSAPEH IRNLSKTLTI
LQKMGGDRLR PTLLTATTTA TGVSDLADEI VDRQQQLAKL TPAFSKEDNE KAIKNLTARK
RKAWSDLLKE LRRVGLSSYL KTDVVSMNQS VMHIYTRPSI LEACPKSLSD ELFPSLEKLF
FRLLAALPKV RDSLHGHSAD LSTAELQRGV NYIEHVTHLV LQERDRMHSE LQMLASLEHL
SARMHTLQSA PLGTATRVSS QAPFHALADF LARLAAALDE IRVQAPKFLA TTAFPAVASD
ALMSRLSSWA TELTNSASLV ETLTEATRAS GPNGLAFLTE QERSHVEASA TLVKSIEEGL
REHLQVMPAL ESLLHPVWTW TAANFGLFEN CLAQTKTPLG ASRETQGLAH QANKLISAVL
QIAQDVRKTG SASAAGTVSA DEASDGLSDK IISSELQALQ AQQAVLRSAS VLSEVQKLFE
LAQQLSRDAE AETFVQVQLA AVYPFLHEFS ALLRTHLLAS AHLSTSLLKL DHVLCHLMTA
LASKGFCKPP EEQENDDGEG DDGEQLEGGT GLGDGSGAKD ITDQMEDDEE IEELQKDDPA
DEGDEGEKTE REKNAKEADQ DFGGDLEDIS GDEEDDAASN QDGDDADEQE PEDAVGDVDP
LDPNAVDEKV WEGGDDEDES KKDAPEDKTN KDLGADNADG DQDDSAPKAD DSAAAADDKQ
RKQEQAADKS REEQPQEQDG DDQPDADKDD DPTNAEDRDG DDSDGVEEEE QEAEADAQGE
GGGRQLDQEA EQAENLDLDD DLNMDGLDGK SEGGSDEDDD LGDLSDVEDM PEDRKEEKVD
EKAMDDLVDD KAQDEEMKDG EEPDAGAEAP EQEQEQEANA QVDKDEGEDA MEEDGEDDED
ESTRKQDRAA DEKPAGPQQI DADPFDTDAV DQGADEGGQD ESAVQQQSSR SAQGRRVDAR
HDQSQADQGM DLDDLADDAT EDQASQPPSA GQRGAQAPKA ERDEASGEAE QDGAAEVDPN
PLRSLGDALE QFRRRMQEIQ KASEDEIEQE AGEEANPDGD GPPEDADVEH VANDENAELQ
ALGAAQEQDE VRKLGDLGIE EVDESMGSKP RAADVDEQQE SEPQAPQPLP DQPENEDRQQ
ADDVEQEAKL DRDGDANMED DVQIKEEQSE EEAMTPLPDD VREEADEEVQ QQLEAFRNVA
SSEERLARAG DLWRSYASLT ADLAFSLCEQ LRLVLAPTLA TRLNGDFRTG KRLNMRKIVP
FIASDFAKDK IWLRRTKPSS REYQVLLAID DSRSMSESRS AHLAYQTLAL VTGALSRLEV
GDVSICRFGE HVESLHDFGK GSFNDQNGAH VIDRLGFQQK KTNVLQLVER SLDTLAEARA
ARPSSSASQG GDLWQLEIII SDGICQDHAR LRSLLRRAAE QRVMLVFVII DSLQPAPTAS
GTSTPGGAGA ATPKAAALQQ ARSSILDMTN ASYHTDANGR LELKMERYMD TFPFDYYVVV
REVEALPEVL SATLRQWVEK IRETES
//
