ID M9MRU0_DROME Unreviewed; 2567 AA.
AC M9MRU0;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE SubName: Full=Wing blister, isoform C {ECO:0000313|EMBL:ADV37056.1};
DE SubName: Full=Wing blister, isoform D {ECO:0000313|EMBL:ADV37057.1};
DE SubName: Full=Wing blister, isoform E {ECO:0000313|EMBL:ADV37058.1};
DE SubName: Full=Wing blister, isoform F {ECO:0000313|EMBL:ADV37059.1};
GN Name=wb {ECO:0000313|EMBL:ADV37057.1,
GN ECO:0000313|FlyBase:FBgn0261563};
GN Synonyms=2 {ECO:0000313|EMBL:ADV37057.1}, 2]]
GN {ECO:0000313|EMBL:ADV37057.1}, 2Lan {ECO:0000313|EMBL:ADV37057.1}, A1
GN {ECO:0000313|EMBL:ADV37057.1}, alpha1 {ECO:0000313|EMBL:ADV37057.1},
GN alpha[[1 {ECO:0000313|EMBL:ADV37057.1}, BEST:CK02229
GN {ECO:0000313|EMBL:ADV37057.1}, BG:DS03792.1
GN {ECO:0000313|EMBL:ADV37057.1}, BG:DS03792.2
GN {ECO:0000313|EMBL:ADV37057.1}, CG15288 {ECO:0000313|EMBL:ADV37057.1},
GN CG32970 {ECO:0000313|EMBL:ADV37057.1}, CK02229
GN {ECO:0000313|EMBL:ADV37057.1}, CT35236 {ECO:0000313|EMBL:ADV37057.1},
GN DLAM {ECO:0000313|EMBL:ADV37057.1}, Dmel\CG42677
GN {ECO:0000313|EMBL:ADV37057.1}, fus5 {ECO:0000313|EMBL:ADV37057.1},
GN l(2)09437 {ECO:0000313|EMBL:ADV37057.1}, l(2)34Fb
GN {ECO:0000313|EMBL:ADV37057.1}, l(2)br1 {ECO:0000313|EMBL:ADV37057.1},
GN l34Fb {ECO:0000313|EMBL:ADV37057.1}, LanA1
GN {ECO:0000313|EMBL:ADV37057.1}, LanWb {ECO:0000313|EMBL:ADV37057.1},
GN LM-A/alpha2 {ECO:0000313|EMBL:ADV37057.1}, Wb
GN {ECO:0000313|EMBL:ADV37057.1};
GN ORFNames=CG42677 {ECO:0000313|EMBL:ADV37057.1,
GN ECO:0000313|FlyBase:FBgn0261563}, Dmel_CG42677
GN {ECO:0000313|EMBL:ADV37057.1};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000313|EMBL:ADV37057.1, ECO:0000313|Proteomes:UP000000803};
RN [1] {ECO:0000313|EMBL:ADV37057.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A.,
RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E.,
RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C.,
RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A.,
RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C.,
RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G.,
RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.,
RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537568;
RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster
RT euchromatic genome sequence.";
RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN [3] {ECO:0000313|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4] {ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537573;
RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M.,
RA Celniker S.E.;
RT "The transposable elements of the Drosophila melanogaster euchromatin: a
RT genomics perspective.";
RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
RN [5] {ECO:0000313|EMBL:ADV37057.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537574;
RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA Karpen G.H.;
RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.";
RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN [6] {ECO:0000313|EMBL:ADV37057.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA Ashburner M., Anxolabehere D.;
RT "Combined evidence annotation of transposable elements in genome
RT sequences.";
RL PLoS Comput. Biol. 1:166-175(2005).
RN [7] {ECO:0000313|EMBL:ADV37057.1}
RP NUCLEOTIDE SEQUENCE.
RA Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S.,
RA Svirskas R., Rubin G.;
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN [8] {ECO:0000313|EMBL:ADV37057.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569856; DOI=10.1126/science.1139815;
RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin.";
RL Science 316:1586-1591(2007).
RN [9] {ECO:0000313|EMBL:ADV37057.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569867; DOI=10.1126/science.1139816;
RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA Dimitri P., Karpen G.H., Celniker S.E.;
RT "Sequence finishing and mapping of Drosophila melanogaster
RT heterochromatin.";
RL Science 316:1625-1628(2007).
RN [10] {ECO:0000313|EMBL:ADV37057.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26109357; DOI=.1534/g3.115.018929;
RG FlyBase Consortium;
RA Matthews B.B., Dos Santos G., Crosby M.A., Emmert D.B., St Pierre S.E.,
RA Gramates L.S., Zhou P., Schroeder A.J., Falls K., Strelets V., Russo S.M.,
RA Gelbart W.M., null;
RT "Gene Model Annotations for Drosophila melanogaster: Impact of High-
RT Throughput Data.";
RL G3 (Bethesda) 5:1721-1736(2015).
RN [11] {ECO:0000313|EMBL:ADV37057.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26109356; DOI=.1534/g3.115.018937;
RG FlyBase Consortium;
RA Crosby M.A., Gramates L.S., Dos Santos G., Matthews B.B., St Pierre S.E.,
RA Zhou P., Schroeder A.J., Falls K., Emmert D.B., Russo S.M., Gelbart W.M.,
RA null;
RT "Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.";
RL G3 (Bethesda) 5:1737-1749(2015).
RN [12] {ECO:0000313|EMBL:ADV37057.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25589440;
RA Hoskins R.A., Carlson J.W., Wan K.H., Park S., Mendez I., Galle S.E.,
RA Booth B.W., Pfeiffer B.D., George R.A., Svirskas R., Krzywinski M.,
RA Schein J., Accardo M.C., Damia E., Messina G., Mendez-Lago M.,
RA de Pablos B., Demakova O.V., Andreyeva E.N., Boldyreva L.V., Marra M.,
RA Carvalho A.B., Dimitri P., Villasante A., Zhimulev I.F., Rubin G.M.,
RA Karpen G.H., Celniker S.E.;
RT "The Release 6 reference sequence of the Drosophila melanogaster genome.";
RL Genome Res. 25:445-458(2015).
RN [13] {ECO:0000313|EMBL:ADV37057.1}
RP NUCLEOTIDE SEQUENCE.
RG Berkeley Drosophila Genome Project;
RA Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R.,
RA Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C.,
RA Rubin G.;
RT "Drosophila melanogaster release 4 sequence.";
RL Submitted (NOV-2022) to the EMBL/GenBank/DDBJ databases.
RN [14] {ECO:0000313|EMBL:ADV37057.1}
RP NUCLEOTIDE SEQUENCE.
RG FlyBase;
RL Submitted (NOV-2022) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix, basement membrane {ECO:0000256|ARBA:ARBA00004302}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
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DR EMBL; AE014134; ADV37056.1; -; Genomic_DNA.
DR EMBL; AE014134; ADV37057.1; -; Genomic_DNA.
DR EMBL; AE014134; ADV37058.1; -; Genomic_DNA.
DR EMBL; AE014134; ADV37059.1; -; Genomic_DNA.
DR RefSeq; NP_001188806.1; NM_001201877.2.
DR RefSeq; NP_001188807.1; NM_001201878.2.
DR RefSeq; NP_001188808.1; NM_001201879.2.
DR RefSeq; NP_001188809.1; NM_001201880.2.
DR SMR; M9MRU0; -.
DR EnsemblMetazoa; FBtr0302732; FBpp0291872; FBgn0261563.
DR EnsemblMetazoa; FBtr0302733; FBpp0291873; FBgn0261563.
DR EnsemblMetazoa; FBtr0302734; FBpp0291874; FBgn0261563.
DR EnsemblMetazoa; FBtr0302735; FBpp0291875; FBgn0261563.
DR GeneID; 43946; -.
DR KEGG; dme:Dmel_CG42677; -.
DR AGR; FB:FBgn0261563; -.
DR CTD; 43946; -.
DR FlyBase; FBgn0261563; wb.
DR VEuPathDB; VectorBase:FBgn0261563; -.
DR GeneTree; ENSGT00940000167067; -.
DR HOGENOM; CLU_000301_0_1_1; -.
DR OMA; TVRQHVH; -.
DR OrthoDB; 90222at2759; -.
DR BioGRID-ORCS; 43946; 0 hits in 3 CRISPR screens.
DR ChiTaRS; wb; fly.
DR GenomeRNAi; 43946; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0261563; Expressed in oviduct (Drosophila) and 21 other cell types or tissues.
DR ExpressionAtlas; M9MRU0; baseline and differential.
DR GO; GO:0005604; C:basement membrane; ISS:FlyBase.
DR GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR GO; GO:0007411; P:axon guidance; IBA:GO_Central.
DR GO; GO:0007502; P:digestive tract mesoderm development; IMP:FlyBase.
DR GO; GO:0008406; P:gonad development; IMP:FlyBase.
DR GO; GO:0009888; P:tissue development; IBA:GO_Central.
DR CDD; cd00055; EGF_Lam; 8.
DR CDD; cd00110; LamG; 4.
DR Gene3D; 2.60.120.200; -; 5.
DR Gene3D; 2.10.25.10; Laminin; 7.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR000034; Laminin_IV.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR10574:SF435; LAMININ SUBUNIT GAMMA-1; 1.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR Pfam; PF00052; Laminin_B; 1.
DR Pfam; PF00053; Laminin_EGF; 6.
DR Pfam; PF02210; Laminin_G_2; 4.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00180; EGF_Lam; 8.
DR SMART; SM00281; LamB; 1.
DR SMART; SM00282; LamG; 5.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 5.
DR SUPFAM; SSF57196; EGF/Laminin; 5.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01248; EGF_LAM_1; 4.
DR PROSITE; PS50027; EGF_LAM_2; 7.
DR PROSITE; PS50025; LAM_G_DOMAIN; 4.
DR PROSITE; PS51115; LAMININ_IVA; 1.
PE 4: Predicted;
KW Basement membrane {ECO:0000256|ARBA:ARBA00022869};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00460}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Reference proteome {ECO:0000313|Proteomes:UP000000803};
KW Secreted {ECO:0000256|ARBA:ARBA00022530}.
FT DOMAIN 342..390
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 391..438
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 486..531
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 532..586
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 627..819
FT /note="Laminin IV type A"
FT /evidence="ECO:0000259|PROSITE:PS51115"
FT DOMAIN 862..909
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 910..964
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 965..1012
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1776..1964
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1968..2187
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 2199..2377
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 2382..2560
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 65..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1226..1260
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1470..1500
FT /evidence="ECO:0000256|SAM:Coils"
FT DISULFID 342..354
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 344..361
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 363..372
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 391..403
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 393..410
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 412..421
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 486..498
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 488..505
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 507..516
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 557..566
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 881..890
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 893..907
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 934..943
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 965..977
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 967..984
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 986..995
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 2533..2560
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00122"
SQ SEQUENCE 2567 AA; 287657 MW; 3CA15610A73730EF CRC64;
MSASDKRTVK MSDASIKPRK LKKHLRAADV KPRGMMTKSL LLHLCVYLVC ITQTLQLQQR
QQQQQQQHRQ QQHGQPEGNM LQQHHRTSVN SSVNINISRQ FNEIIQTATA SASASGTGSA
SGAVTFASVT AATTITPGRR KLRRKFQGQQ NRNSTLGRRR KLRLHPYHRR NATHATRTTT
VASVSATATT LLPKMPHKQP FNYHTHLHSS FQQQQQQQHV AGGQVTQQQQ QQQQVHVVAV
TPRPQQRQQQ PGFAIVPATY YHQQQQQQQR TLLGNLTQQQ QQQQQHLLIQ PGQNILVYSN
LGPIPPCPPG LLSGSGMPVY TQQQHFIPLR STTTPRPRQR ECHCSSVGSL SSDCDKRTGQ
CACLANVTGR RCDKCRPGHW NLTAGEGCRD CRCDPHGSRG HECNPWTGQC DCKIGVGGQH
CNECTEGFFG FSTEGCQRCS ACRSEGQVCD PHNGRCICPK FTRGLGCGQC VPGTWGWQAR
LGCRECECDH IGSIGQQCST GDGQCQCREG YSGRKCDTCA IGYFGYPECR RCGCDAEGSF
TQADGSIACD SNGQCPCKSL VVGLKCDTCM QSTFGLSAQN PEGCTRCFCF GRSGECEQSD
LSWGHIRMAE SRNLSVQQIR PHSVPSSDYE YIVVVQMEGS SFHREDAEIQ RMNDLSLVPK
STGNVSIGAY GQFYHPLYFQ LPPQFYGDRT SSYGGFLYFT LITEGAHKPL ERNILGQYPL
VQLHAHSKLL LDFYEYEEFE YSLNVTHRVP LHESFWKYHH TSQAVDRNTL MAALQNIRHI
FIRAFAFADF QEVVLQNVHM DAAIYIKGST NLIAKGVERC KCPKRFDGLS CQDPGRSFYR
WRNTTIVESV FIEDLIGRAA PCHCNGRSSD CDRETGVCQN CRGNTGGDHC HQCAEGFYGD
PNSPHGCQAC PCPETNRNFA RGCNVWDGEV SCVCKPGYTG RLCERCQAGY FGDPMRYPNT
TCQPCNCHPD GIQTEGCDVE TGRCYCREGV TGLKCDKCQA ERHHLVDNGC KICDNCTLLL
LDYMELVGNK LRRGMHNMDL TGIPAPYRKL SEYESAYEKW NGRHWDFSQT KRRLQDYDSA
DILKLEAHAE NLKFQSRKAV ATIGKREFAI KSMREDAVTQ QHSVGLLRSE ILQTLSDLHG
YGKSAHYLSL PTALKQARFY LQAIREHDQM VQGIRSTNDC AWKHFYAMGN ASDASFDESG
RLEMLWRDLN QTNHRVVDMR LQVDRVQEVE NEAEDVLEHV RNLSIRVGES HQELDELNQR
ISDHLDPGYL EQGEGLLRLT VQRQIMLNGH LNQLDGYRIL LNTTLGVKTE QQREVRKHWL
PKAEKHASHL LARSNEYARK FQPTRNGARI AMLASSAHSN ITEAINDARL ASILAKERVY
EAQRTLYPSD GSSMIERAKH SLHRSKQLQQ EALKQMHKSN VLKDKLHRQE QQVEGIKSTI
YDSGLRTNNI SGQLQGLSDG SARRQAKDSL EMADRTGEQM RAELQKAKDM QKSIQNMRNS
FSNLEPDWEI KLGMAQENIS LTQTNLRLAN VSLSYLEQQA EKEQQVFEVW NNSMAQQLQQ
LRDQIAKARH AAEAIDVSLE SLGPKCIRSY LPASYGLSTS NKIRMSFALS NHLESSPLIH
LASSEGRHIT LELYKRRVRL VWNLGGTTAT VTHPMVVHTR DPKYDDAWYH VEANRTLNLG
SLVVRRMNNY GELTPPNPVI ITGSTDTEHT RFYQSRSDRI SLGGFASKDL QFTPGLNVVV
HQVEVDNKPL GLWNFVTSEG SCGGSMVGAK ESSASSTARH FNGLGYAQLM KTRPRPTRKN
LFSVQMTFRT LDENALLFLA VDDKNNRSVS VTLSRGRIMF RIDYGDESKL EINTTKKYNV
GQWIKIEAAR EFSAKRSTEN GMLRVNNDRP ISGAPTLPVN IHLLPDLSKT VYYLGGVPPG
FTSGTSKAPG ADNPFLGCMK DVQVNGETYD PLESSSYYGV EPSCKNMITK AGFSGNGYLE
LPSQSLRKRS NTALVFRTLQ PDCLLLLAAY PPEILGDYDA KDIKGNFSIS LVDGQLHVWV
NSGRSFIKMS SNSSQMNDGE FHVVHLIKTG RKLELMVDDE LQEIRNLNGN PTVVSLPRDA
GGLYIGGAPP HESYTPLAPT FVNLEGAIRD VVFNNRTINF NDALTFANVQ IGRNGPLMGS
LKGGLYDVLL KTEPMIGKSF TASPEGCKRI GSYSYEPNAF KFGDDIYSYS QLKLPERHFW
QRNFHLSFDF RSFYPNGMLY LSPGSKEKPK HYVALVLKDG QLVLVVRGRR REELQLTAKL
NDGEWHRVTI SCHDRKVTMS VEIGRTDQKT SAQMKLPKKI GASQLLLVGG LPQSPVKVSS
DLYVRLEPFK GCLRRVSINN NTQDLARPGK HSNVGQCFPT VERGSYFPGD AYAIYKKNFN
VGKYLDLETE FRTSELSGIL LSVSDPNGFP ALSLELHNGN IIFSCDPGNG APMRVESSLP
TKYALCDNKW HNISALYDGE QIVLRIDQLP AVISVGNQGN AGKVQTRSPL YIGGLPESAP
SGSLISRENF KGCIRHVSIR NERRDWIEME DLRNVLLSEC LVSSDES
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