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Database: UniProt
Entry: M9ND42_DROME
LinkDB: M9ND42_DROME
Original site: M9ND42_DROME 
ID   M9ND42_DROME            Unreviewed;       644 AA.
AC   M9ND42;
DT   26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 1.
DT   18-JUL-2018, entry version 50.
DE   SubName: Full=Cdc42-interacting protein 4, isoform H {ECO:0000313|EMBL:AFH04287.1};
GN   Name=Cip4 {ECO:0000313|EMBL:AFH04287.1,
GN   ECO:0000313|FlyBase:FBgn0035533};
GN   Synonyms=CG11341 {ECO:0000313|EMBL:AFH04287.1}, cip4
GN   {ECO:0000313|EMBL:AFH04287.1}, DCIP4 {ECO:0000313|EMBL:AFH04287.1},
GN   dCIP4 {ECO:0000313|EMBL:AFH04287.1}, dcip4
GN   {ECO:0000313|EMBL:AFH04287.1}, Dmel\CG15015
GN   {ECO:0000313|EMBL:AFH04287.1};
GN   ORFNames=CG15015 {ECO:0000313|EMBL:AFH04287.1,
GN   ECO:0000313|FlyBase:FBgn0035533}, Dmel_CG15015
GN   {ECO:0000313|EMBL:AFH04287.1};
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227 {ECO:0000313|EMBL:AFH04287.1, ECO:0000313|Proteomes:UP000000803};
RN   [1] {ECO:0000313|EMBL:AFH04287.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
RA   Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D.,
RA   Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L.,
RA   Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D.,
RA   Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
RA   Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
RA   Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
RA   Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
RA   Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
RA   de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
RA   Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
RA   Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
RA   Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
RA   Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J.,
RA   Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C.,
RA   Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
RA   Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z.,
RA   Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X.,
RA   Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
RA   Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
RA   Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
RA   Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
RA   Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
RA   Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA   Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
RA   Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
RA   Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
RA   Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J.,
RA   Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
RA   Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O.,
RA   Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2] {ECO:0000313|EMBL:AFH04287.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537568;
RA   Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA   Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA   George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA   Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA   Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA   Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT   "Finishing a whole-genome shotgun: release 3 of the Drosophila
RT   melanogaster euchromatic genome sequence.";
RL   Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN   [3] {ECO:0000313|EMBL:AFH04287.1, ECO:0000313|Proteomes:UP000000803}
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
RA   Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
RA   Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a
RT   systematic review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [4] {ECO:0000313|EMBL:AFH04287.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537573;
RA   Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA   Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M.,
RA   Ashburner M., Celniker S.E.;
RT   "The transposable elements of the Drosophila melanogaster euchromatin:
RT   a genomics perspective.";
RL   Genome Biol. 3:RESEARCH0084-RESEARCH0084(2002).
RN   [5] {ECO:0000313|EMBL:AFH04287.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537574;
RA   Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA   Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA   Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA   Karpen G.H.;
RT   "Heterochromatic sequences in a Drosophila whole-genome shotgun
RT   assembly.";
RL   Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN   [6] {ECO:0000313|EMBL:AFH04287.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA   Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA   Ashburner M., Anxolabehere D.;
RT   "Combined evidence annotation of transposable elements in genome
RT   sequences.";
RL   PLoS Comput. Biol. 1:166-175(2005).
RN   [7] {ECO:0000313|EMBL:AFH04287.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=17569856; DOI=10.1126/science.1139815;
RA   Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT   "The Release 5.1 annotation of Drosophila melanogaster
RT   heterochromatin.";
RL   Science 316:1586-1591(2007).
RN   [8] {ECO:0000313|EMBL:AFH04287.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=17569867; DOI=10.1126/science.1139816;
RA   Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA   Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA   Dimitri P., Karpen G.H., Celniker S.E.;
RT   "Sequence finishing and mapping of Drosophila melanogaster
RT   heterochromatin.";
RL   Science 316:1625-1628(2007).
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DR   EMBL; AE014296; AFH04287.1; -; Genomic_DNA.
DR   RefSeq; NP_001246616.1; NM_001259687.2.
DR   UniGene; Dm.7348; -.
DR   ProteinModelPortal; M9ND42; -.
DR   PRIDE; M9ND42; -.
DR   EnsemblMetazoa; FBtr0308201; FBpp0300521; FBgn0035533.
DR   GeneID; 38534; -.
DR   CTD; 38534; -.
DR   FlyBase; FBgn0035533; Cip4.
DR   eggNOG; ENOG410INNY; Eukaryota.
DR   eggNOG; ENOG410ZU0I; LUCA.
DR   GeneTree; ENSGT00510000046403; -.
DR   OrthoDB; EOG091G09HM; -.
DR   Reactome; R-DME-194840; Rho GTPase cycle.
DR   Reactome; R-DME-8856828; Clathrin-mediated endocytosis.
DR   GenomeRNAi; 38534; -.
DR   Proteomes; UP000000803; Chromosome 3L.
DR   Bgee; FBgn0035533; -.
DR   ExpressionAtlas; M9ND42; baseline and differential.
DR   GO; GO:0032154; C:cleavage furrow; IDA:FlyBase.
DR   GO; GO:0030496; C:midbody; IDA:FlyBase.
DR   GO; GO:0031594; C:neuromuscular junction; IDA:FlyBase.
DR   GO; GO:0005886; C:plasma membrane; IDA:FlyBase.
DR   GO; GO:0012506; C:vesicle membrane; IDA:FlyBase.
DR   GO; GO:0032794; F:GTPase activating protein binding; IPI:FlyBase.
DR   GO; GO:0008289; F:lipid binding; IDA:FlyBase.
DR   GO; GO:0005543; F:phospholipid binding; ISM:FlyBase.
DR   GO; GO:0034613; P:cellular protein localization; IMP:FlyBase.
DR   GO; GO:0007349; P:cellularization; IMP:FlyBase.
DR   GO; GO:0030708; P:germarium-derived female germ-line cyst encapsulation; IMP:FlyBase.
DR   GO; GO:0035317; P:imaginal disc-derived wing hair organization; IMP:FlyBase.
DR   GO; GO:0007498; P:mesoderm development; IEP:FlyBase.
DR   GO; GO:0030837; P:negative regulation of actin filament polymerization; IDA:FlyBase.
DR   GO; GO:0051126; P:negative regulation of actin nucleation; IDA:FlyBase.
DR   GO; GO:0045886; P:negative regulation of synaptic growth at neuromuscular junction; IMP:FlyBase.
DR   GO; GO:0007009; P:plasma membrane organization; IMP:FlyBase.
DR   GO; GO:0097320; P:plasma membrane tubulation; IDA:FlyBase.
DR   GO; GO:0008104; P:protein localization; IMP:FlyBase.
DR   GO; GO:1903391; P:regulation of adherens junction organization; IMP:FlyBase.
DR   GO; GO:0008582; P:regulation of synaptic growth at neuromuscular junction; IDA:FlyBase.
DR   Gene3D; 1.20.1270.60; -; 1.
DR   InterPro; IPR027267; AH/BAR_dom_sf.
DR   InterPro; IPR031160; F_BAR.
DR   InterPro; IPR001060; FCH_dom.
DR   InterPro; IPR036274; HR1_rpt_sf.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   Pfam; PF00611; FCH; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   SMART; SM00055; FCH; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF103657; SSF103657; 1.
DR   SUPFAM; SSF46585; SSF46585; 1.
DR   SUPFAM; SSF50044; SSF50044; 1.
DR   PROSITE; PS51741; F_BAR; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077,
KW   ECO:0000256|SAAS:SAAS00803874, ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000803};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000803};
KW   SH3 domain {ECO:0000256|PROSITE-ProRule:PRU00192,
KW   ECO:0000256|SAAS:SAAS00989295}.
FT   DOMAIN       31    292       F-BAR. {ECO:0000259|PROSITE:PS51741}.
FT   DOMAIN      578    643       SH3. {ECO:0000259|PROSITE:PS50002}.
FT   COILED      152    186       {ECO:0000256|SAM:Coils}.
FT   COILED      208    231       {ECO:0000256|SAM:Coils}.
FT   COILED      394    414       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   644 AA;  71862 MW;  19FEC1E5989AC365 CRC64;
     MLALLASGSS RSSSNNKLAE SENSAQNSNN MSWGTELWDQ NENLAIHTNR GIDALDKFAN
     FLRDRVAIET EYAGKLRRLV KNYQPKKKEE EDNEFTSVQA FRNLLKEVGD LAGQREVVSE
     SLQLQIIAGV TLLSKTLREE RKKCLSDGAT LQQNLTTQLS SLDRAKRNYE KAYRDSEKAV
     DSYKRADMDL NLSRAEVERY KNVMTSKIQQ SDDAKNEYAN QLQKTNNLQQ QHYSMLLPSV
     LNRLQELDEK RTRGFREFIV GAADVESSVA PIIARCMEGI VKAGESINEK EDTFKVIERY
     QSGFTPPRDI PFEDLSKCDP DSVQDSHYSN STSNHLTIRG TMSANKLKKR VGIFNIFGSN
     KQRQIIEACI TMKNSLTADG QKEDFSDLPP NQRRKKLQAK IAELTQNIAQ ETKARDGLMK
     MKIVYEANSS LGNPMTVEGQ LNESEHKLEK LKVDLKKYQG FLEKASQVPT ATSSPQASRN
     QLQNGHRTSR HSNGSADDHH DDGDDQPDDA GSLSRSDSED NVAQIQNGHN NNNNGSSASP
     ESGLGTSHTS LPGSGQGSAN ENAIGEDTYY ETEVETLNPV GKCRALYPFE ASSEGSIPMS
     EGEELQVIEI DQGDGWTRVR RENNSNGWDE GFVPTSYIEI TLYA
//
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