ID M9ND66_DROME Unreviewed; 1744 AA.
AC M9ND66;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 24-JAN-2024, entry version 73.
DE SubName: Full=Formin homology 2 domain containing, isoform H {ECO:0000313|EMBL:AFH04355.1};
GN Name=Fhos {ECO:0000313|EMBL:AFH04355.1,
GN ECO:0000313|FlyBase:FBgn0266084};
GN Synonyms=CG32025 {ECO:0000313|EMBL:AFH04355.1}, CG32030
GN {ECO:0000313|EMBL:AFH04355.1}, CG5775 {ECO:0000313|EMBL:AFH04355.1},
GN CG5797 {ECO:0000313|EMBL:AFH04355.1}, desert
GN {ECO:0000313|EMBL:AFH04355.1}, dFHOS {ECO:0000313|EMBL:AFH04355.1},
GN Dmel\CG42610 {ECO:0000313|EMBL:AFH04355.1}, fhos
GN {ECO:0000313|EMBL:AFH04355.1}, jaz {ECO:0000313|EMBL:AFH04355.1}, knit
GN {ECO:0000313|EMBL:AFH04355.1}, l(3)01629
GN {ECO:0000313|EMBL:AFH04355.1};
GN ORFNames=CG42610 {ECO:0000313|EMBL:AFH04355.1,
GN ECO:0000313|FlyBase:FBgn0266084}, Dmel_CG42610
GN {ECO:0000313|EMBL:AFH04355.1};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AFH04355.1, ECO:0000313|Proteomes:UP000000803};
RN [1] {ECO:0000313|EMBL:AFH04355.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A.,
RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E.,
RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C.,
RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A.,
RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C.,
RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G.,
RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.,
RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537568;
RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster
RT euchromatic genome sequence.";
RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN [3] {ECO:0000313|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4] {ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537573;
RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M.,
RA Celniker S.E.;
RT "The transposable elements of the Drosophila melanogaster euchromatin: a
RT genomics perspective.";
RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
RN [5] {ECO:0000313|EMBL:AFH04355.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537574;
RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA Karpen G.H.;
RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.";
RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN [6] {ECO:0000313|EMBL:AFH04355.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA Ashburner M., Anxolabehere D.;
RT "Combined evidence annotation of transposable elements in genome
RT sequences.";
RL PLoS Comput. Biol. 1:166-175(2005).
RN [7] {ECO:0000313|EMBL:AFH04355.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569856; DOI=10.1126/science.1139815;
RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin.";
RL Science 316:1586-1591(2007).
RN [8] {ECO:0000313|EMBL:AFH04355.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569867; DOI=10.1126/science.1139816;
RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA Dimitri P., Karpen G.H., Celniker S.E.;
RT "Sequence finishing and mapping of Drosophila melanogaster
RT heterochromatin.";
RL Science 316:1625-1628(2007).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE014296; AFH04355.1; -; Genomic_DNA.
DR RefSeq; NP_001246684.1; NM_001259755.1.
DR SMR; M9ND66; -.
DR EnsemblMetazoa; FBtr0306632; FBpp0297587; FBgn0266084.
DR GeneID; 39004; -.
DR AGR; FB:FBgn0266084; -.
DR CTD; 39004; -.
DR FlyBase; FBgn0266084; Fhos.
DR VEuPathDB; VectorBase:FBgn0266084; -.
DR HOGENOM; CLU_000814_1_0_1; -.
DR OrthoDB; 2918313at2759; -.
DR BioGRID-ORCS; 39004; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 39004; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0266084; Expressed in oviduct (Drosophila) and 36 other cell types or tissues.
DR ExpressionAtlas; M9ND66; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IDA:FlyBase.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:FlyBase.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0030866; P:cortical actin cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0007476; P:imaginal disc-derived wing morphogenesis; IMP:FlyBase.
DR GO; GO:0046716; P:muscle cell cellular homeostasis; IMP:FlyBase.
DR GO; GO:0003012; P:muscle system process; IGI:FlyBase.
DR GO; GO:0030335; P:positive regulation of cell migration; IMP:FlyBase.
DR GO; GO:0051496; P:positive regulation of stress fiber assembly; IMP:FlyBase.
DR GO; GO:1900026; P:positive regulation of substrate adhesion-dependent cell spreading; IMP:FlyBase.
DR GO; GO:0010623; P:programmed cell death involved in cell development; IMP:FlyBase.
DR GO; GO:0035070; P:salivary gland histolysis; IMP:FlyBase.
DR GO; GO:0060439; P:trachea morphogenesis; IMP:FlyBase.
DR GO; GO:0044319; P:wound healing, spreading of cells; IMP:FlyBase.
DR Gene3D; 1.20.58.2220; Formin, FH2 domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR014767; DAD_dom.
DR InterPro; IPR015425; FH2_Formin.
DR InterPro; IPR042201; FH2_Formin_sf.
DR InterPro; IPR041387; FHOD1_GBD_N.
DR InterPro; IPR014768; GBD/FH3_dom.
DR PANTHER; PTHR45920; FORMIN HOMOLOGY 2 DOMAIN CONTAINING, ISOFORM I; 1.
DR PANTHER; PTHR45920:SF4; FORMIN HOMOLOGY 2 DOMAIN CONTAINING, ISOFORM I; 1.
DR Pfam; PF02181; FH2; 1.
DR Pfam; PF18382; Formin_GBD_N; 1.
DR SMART; SM00498; FH2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR PROSITE; PS51231; DAD; 1.
DR PROSITE; PS51444; FH2; 1.
DR PROSITE; PS51232; GBD_FH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000000803}.
FT DOMAIN 407..770
FT /note="GBD/FH3"
FT /evidence="ECO:0000259|PROSITE:PS51232"
FT DOMAIN 1234..1625
FT /note="FH2"
FT /evidence="ECO:0000259|PROSITE:PS51444"
FT DOMAIN 1683..1715
FT /note="DAD"
FT /evidence="ECO:0000259|PROSITE:PS51231"
FT REGION 37..198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 258..305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 686..730
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 742..783
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 975..1060
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1108..1139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1694..1730
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 917..944
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 42..67
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 69..90
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..137
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..180
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 689..704
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 705..720
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 742..761
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 987..1028
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1033..1047
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1110..1139
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1744 AA; 196001 MW; 908F5330F6D4D5CA CRC64;
MPSYRLRHID SGEEQAWWLR QDENGDDDDT LAEETLNTLD DDLQEPSKST WWSQDDQDSS
SQVKLMPRSR ITPEKDAWWL QDEDEAAKSP IENGDLNNNN NSEPHVEVTL RLPSNGSQRS
SKSSASKNGS NPKSGGANPW WLSGPARKMF NVQRVESGER AWWQEEAEEP PQEEKESEPP
PVKPPTPPPR IIKHWESGER AWWLQDETES NQLPVQASSD DEEQPVLVVI NQQESRDEVD
LRLAPPTLES QELSNSFNFD AHSERPPPLG QCASPVRCPS PYDNIPRSQL QEPPPPPTTT
LTSLQPRFSP QTRRAGEKLF ISRHQNIDEL LGGACRPLSP LFYGNSNPAE SELTPLAGKN
MFLLEEVTPD QVRIHDSTAQ LPVIQRMQRD VEWLDNGSNF YEPPEQRQHQ PPRRIDDAAI
QVYKDGDYGA YLDLESSLAE QAEEIEGVNV SRKNSLVVRT QLNVRVQAII EKLLSAQGSD
LRRALFSLKQ VFQEDKDLVH AFVALGGLNC LVRVGNCADQ NYQNYILRAL GQVMLYVDGM
NGVMKHEPTM QWLYSLIASN YRSVVKTALK LLLVFVEYAE SNCYVLVSAI HAVDASQGTL
PWSNIMRLLK DYDNADAELV IYATSLINKT LAGLNDQDSF YDESDLLEQQ GMETVIQRYM
SKPGTDLDLL DQLQLYEAVL KFEDGESDGQ RLPQNSMRKT QRYRPGANTT ERRKSRRHST
DNSPASLTKV LPTTVLRMTP TQATVDEDSS GSTNSTEFSG GLFNEKKPRD GAGVTPGLRR
RRERAERHKS FLKEQQEAAA NGIFAALEQR EGLGQIVTAI PATIQTGDSP PQSLQHEVPP
CNNISGITNI SNNNVSNLSC NDTPNNSLLV MSPSKQLLTG SHSISIINNS FDKASNNNQS
EFLTKKNLFR ERNSTVINGI MKNIQQTDSA YKKYENEANR LNNYYSQSPK HQIHQPIQPT
PEVLLSPKKT LNASGFDFTP APLSSTPVKC DVPPEPEPLS PVKKPAAAPP PPPPPPPPPP
PPPGWWHAPI YNSPQARTLT STNPELLPHP VDPSDMESED QQLLLQLKRD HTVKDLTQKL
SNLPMSPTQD SANRALVGDM SGLISKAKEG LAKSKSKGEI SRSSSVDQDV KKSEPKKSEN
ELHWEELVRN MTRPLNLCDL DFTDLRDDDE KDVLAPRSLG AGIPPPPPPL GGAIAPPPMM
PPSLAPPPMY GYGGSLTNSV NSLNGSINGE LVNGNNTIKK NKKTVKLFWK EVREDMIPQV
VGKTIWDELP DANVDTQKLE HLFESRAKDL MTKKQQELNK SKEIIVLDHK RSNAINIAIT
KLPPPRAIKT AILKMDATVV TREGIDKLLN MLPTDEERGK IQEAQLSNPE LPLGSAEQFL
LTLASISELE ARLKLWAFRL DFDNSEKEIA EPLMDLKQGI EILRQNRTFR SILSTLLSVG
IFLNGAPVKG FQIEYLAKVP EVKDTVHKHS LLHHLCHMVM ESSSDTSDLY SEIGPITRAS
KADFTDLAHN LNQLEAECKA CWDRLKLIAK HDCPPPLKQK LVDFLADCAE RIIILQIVHR
RVMNRYRKFL LWLGMPQHSV AESRPNEFCR TLSEFALEYR TTRERVQQQL EKKANHRERN
KTRGKLIIDM AKFKTKDDVA DDELKKLLDT SSADQADGTL TWRRRRAEQL RSPITRQSEE
QFTDGDDEIL ESLVKTATKA PGTRTTPRER KRTRHADRKS LRRTLKNGLT EEEKQHVAAL
IQTY
//