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Database: UniProt
Entry: M9ND66_DROME
LinkDB: M9ND66_DROME
Original site: M9ND66_DROME 
ID   M9ND66_DROME            Unreviewed;      1744 AA.
AC   M9ND66;
DT   26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 1.
DT   24-JAN-2024, entry version 73.
DE   SubName: Full=Formin homology 2 domain containing, isoform H {ECO:0000313|EMBL:AFH04355.1};
GN   Name=Fhos {ECO:0000313|EMBL:AFH04355.1,
GN   ECO:0000313|FlyBase:FBgn0266084};
GN   Synonyms=CG32025 {ECO:0000313|EMBL:AFH04355.1}, CG32030
GN   {ECO:0000313|EMBL:AFH04355.1}, CG5775 {ECO:0000313|EMBL:AFH04355.1},
GN   CG5797 {ECO:0000313|EMBL:AFH04355.1}, desert
GN   {ECO:0000313|EMBL:AFH04355.1}, dFHOS {ECO:0000313|EMBL:AFH04355.1},
GN   Dmel\CG42610 {ECO:0000313|EMBL:AFH04355.1}, fhos
GN   {ECO:0000313|EMBL:AFH04355.1}, jaz {ECO:0000313|EMBL:AFH04355.1}, knit
GN   {ECO:0000313|EMBL:AFH04355.1}, l(3)01629
GN   {ECO:0000313|EMBL:AFH04355.1};
GN   ORFNames=CG42610 {ECO:0000313|EMBL:AFH04355.1,
GN   ECO:0000313|FlyBase:FBgn0266084}, Dmel_CG42610
GN   {ECO:0000313|EMBL:AFH04355.1};
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227 {ECO:0000313|EMBL:AFH04355.1, ECO:0000313|Proteomes:UP000000803};
RN   [1] {ECO:0000313|EMBL:AFH04355.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A.,
RA   An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA   Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E.,
RA   Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C.,
RA   Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A.,
RA   Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C.,
RA   Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G.,
RA   Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.,
RA   Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2] {ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537568;
RA   Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA   Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA   George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA   Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA   Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA   Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT   "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster
RT   euchromatic genome sequence.";
RL   Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN   [3] {ECO:0000313|Proteomes:UP000000803}
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [4] {ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537573;
RA   Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA   Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M.,
RA   Celniker S.E.;
RT   "The transposable elements of the Drosophila melanogaster euchromatin: a
RT   genomics perspective.";
RL   Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
RN   [5] {ECO:0000313|EMBL:AFH04355.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537574;
RA   Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA   Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA   Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA   Karpen G.H.;
RT   "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.";
RL   Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN   [6] {ECO:0000313|EMBL:AFH04355.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA   Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA   Ashburner M., Anxolabehere D.;
RT   "Combined evidence annotation of transposable elements in genome
RT   sequences.";
RL   PLoS Comput. Biol. 1:166-175(2005).
RN   [7] {ECO:0000313|EMBL:AFH04355.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=17569856; DOI=10.1126/science.1139815;
RA   Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT   "The Release 5.1 annotation of Drosophila melanogaster heterochromatin.";
RL   Science 316:1586-1591(2007).
RN   [8] {ECO:0000313|EMBL:AFH04355.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=17569867; DOI=10.1126/science.1139816;
RA   Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA   Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA   Dimitri P., Karpen G.H., Celniker S.E.;
RT   "Sequence finishing and mapping of Drosophila melanogaster
RT   heterochromatin.";
RL   Science 316:1625-1628(2007).
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DR   EMBL; AE014296; AFH04355.1; -; Genomic_DNA.
DR   RefSeq; NP_001246684.1; NM_001259755.1.
DR   SMR; M9ND66; -.
DR   EnsemblMetazoa; FBtr0306632; FBpp0297587; FBgn0266084.
DR   GeneID; 39004; -.
DR   AGR; FB:FBgn0266084; -.
DR   CTD; 39004; -.
DR   FlyBase; FBgn0266084; Fhos.
DR   VEuPathDB; VectorBase:FBgn0266084; -.
DR   HOGENOM; CLU_000814_1_0_1; -.
DR   OrthoDB; 2918313at2759; -.
DR   BioGRID-ORCS; 39004; 0 hits in 3 CRISPR screens.
DR   GenomeRNAi; 39004; -.
DR   Proteomes; UP000000803; Chromosome 3L.
DR   Bgee; FBgn0266084; Expressed in oviduct (Drosophila) and 36 other cell types or tissues.
DR   ExpressionAtlas; M9ND66; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IDA:FlyBase.
DR   GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:FlyBase.
DR   GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR   GO; GO:0030866; P:cortical actin cytoskeleton organization; IBA:GO_Central.
DR   GO; GO:0007476; P:imaginal disc-derived wing morphogenesis; IMP:FlyBase.
DR   GO; GO:0046716; P:muscle cell cellular homeostasis; IMP:FlyBase.
DR   GO; GO:0003012; P:muscle system process; IGI:FlyBase.
DR   GO; GO:0030335; P:positive regulation of cell migration; IMP:FlyBase.
DR   GO; GO:0051496; P:positive regulation of stress fiber assembly; IMP:FlyBase.
DR   GO; GO:1900026; P:positive regulation of substrate adhesion-dependent cell spreading; IMP:FlyBase.
DR   GO; GO:0010623; P:programmed cell death involved in cell development; IMP:FlyBase.
DR   GO; GO:0035070; P:salivary gland histolysis; IMP:FlyBase.
DR   GO; GO:0060439; P:trachea morphogenesis; IMP:FlyBase.
DR   GO; GO:0044319; P:wound healing, spreading of cells; IMP:FlyBase.
DR   Gene3D; 1.20.58.2220; Formin, FH2 domain; 1.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR014767; DAD_dom.
DR   InterPro; IPR015425; FH2_Formin.
DR   InterPro; IPR042201; FH2_Formin_sf.
DR   InterPro; IPR041387; FHOD1_GBD_N.
DR   InterPro; IPR014768; GBD/FH3_dom.
DR   PANTHER; PTHR45920; FORMIN HOMOLOGY 2 DOMAIN CONTAINING, ISOFORM I; 1.
DR   PANTHER; PTHR45920:SF4; FORMIN HOMOLOGY 2 DOMAIN CONTAINING, ISOFORM I; 1.
DR   Pfam; PF02181; FH2; 1.
DR   Pfam; PF18382; Formin_GBD_N; 1.
DR   SMART; SM00498; FH2; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR   PROSITE; PS51231; DAD; 1.
DR   PROSITE; PS51444; FH2; 1.
DR   PROSITE; PS51232; GBD_FH3; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000803}.
FT   DOMAIN          407..770
FT                   /note="GBD/FH3"
FT                   /evidence="ECO:0000259|PROSITE:PS51232"
FT   DOMAIN          1234..1625
FT                   /note="FH2"
FT                   /evidence="ECO:0000259|PROSITE:PS51444"
FT   DOMAIN          1683..1715
FT                   /note="DAD"
FT                   /evidence="ECO:0000259|PROSITE:PS51231"
FT   REGION          37..198
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          258..305
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          686..730
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          742..783
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          975..1060
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1108..1139
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1694..1730
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          917..944
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        42..67
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        69..90
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        92..137
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        159..180
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        689..704
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        705..720
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        742..761
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        987..1028
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1033..1047
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1110..1139
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1744 AA;  196001 MW;  908F5330F6D4D5CA CRC64;
     MPSYRLRHID SGEEQAWWLR QDENGDDDDT LAEETLNTLD DDLQEPSKST WWSQDDQDSS
     SQVKLMPRSR ITPEKDAWWL QDEDEAAKSP IENGDLNNNN NSEPHVEVTL RLPSNGSQRS
     SKSSASKNGS NPKSGGANPW WLSGPARKMF NVQRVESGER AWWQEEAEEP PQEEKESEPP
     PVKPPTPPPR IIKHWESGER AWWLQDETES NQLPVQASSD DEEQPVLVVI NQQESRDEVD
     LRLAPPTLES QELSNSFNFD AHSERPPPLG QCASPVRCPS PYDNIPRSQL QEPPPPPTTT
     LTSLQPRFSP QTRRAGEKLF ISRHQNIDEL LGGACRPLSP LFYGNSNPAE SELTPLAGKN
     MFLLEEVTPD QVRIHDSTAQ LPVIQRMQRD VEWLDNGSNF YEPPEQRQHQ PPRRIDDAAI
     QVYKDGDYGA YLDLESSLAE QAEEIEGVNV SRKNSLVVRT QLNVRVQAII EKLLSAQGSD
     LRRALFSLKQ VFQEDKDLVH AFVALGGLNC LVRVGNCADQ NYQNYILRAL GQVMLYVDGM
     NGVMKHEPTM QWLYSLIASN YRSVVKTALK LLLVFVEYAE SNCYVLVSAI HAVDASQGTL
     PWSNIMRLLK DYDNADAELV IYATSLINKT LAGLNDQDSF YDESDLLEQQ GMETVIQRYM
     SKPGTDLDLL DQLQLYEAVL KFEDGESDGQ RLPQNSMRKT QRYRPGANTT ERRKSRRHST
     DNSPASLTKV LPTTVLRMTP TQATVDEDSS GSTNSTEFSG GLFNEKKPRD GAGVTPGLRR
     RRERAERHKS FLKEQQEAAA NGIFAALEQR EGLGQIVTAI PATIQTGDSP PQSLQHEVPP
     CNNISGITNI SNNNVSNLSC NDTPNNSLLV MSPSKQLLTG SHSISIINNS FDKASNNNQS
     EFLTKKNLFR ERNSTVINGI MKNIQQTDSA YKKYENEANR LNNYYSQSPK HQIHQPIQPT
     PEVLLSPKKT LNASGFDFTP APLSSTPVKC DVPPEPEPLS PVKKPAAAPP PPPPPPPPPP
     PPPGWWHAPI YNSPQARTLT STNPELLPHP VDPSDMESED QQLLLQLKRD HTVKDLTQKL
     SNLPMSPTQD SANRALVGDM SGLISKAKEG LAKSKSKGEI SRSSSVDQDV KKSEPKKSEN
     ELHWEELVRN MTRPLNLCDL DFTDLRDDDE KDVLAPRSLG AGIPPPPPPL GGAIAPPPMM
     PPSLAPPPMY GYGGSLTNSV NSLNGSINGE LVNGNNTIKK NKKTVKLFWK EVREDMIPQV
     VGKTIWDELP DANVDTQKLE HLFESRAKDL MTKKQQELNK SKEIIVLDHK RSNAINIAIT
     KLPPPRAIKT AILKMDATVV TREGIDKLLN MLPTDEERGK IQEAQLSNPE LPLGSAEQFL
     LTLASISELE ARLKLWAFRL DFDNSEKEIA EPLMDLKQGI EILRQNRTFR SILSTLLSVG
     IFLNGAPVKG FQIEYLAKVP EVKDTVHKHS LLHHLCHMVM ESSSDTSDLY SEIGPITRAS
     KADFTDLAHN LNQLEAECKA CWDRLKLIAK HDCPPPLKQK LVDFLADCAE RIIILQIVHR
     RVMNRYRKFL LWLGMPQHSV AESRPNEFCR TLSEFALEYR TTRERVQQQL EKKANHRERN
     KTRGKLIIDM AKFKTKDDVA DDELKKLLDT SSADQADGTL TWRRRRAEQL RSPITRQSEE
     QFTDGDDEIL ESLVKTATKA PGTRTTPRER KRTRHADRKS LRRTLKNGLT EEEKQHVAAL
     IQTY
//
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