GenomeNet

Database: UniProt
Entry: M9NDL5_DROME
LinkDB: M9NDL5_DROME
Original site: M9NDL5_DROME 
ID   M9NDL5_DROME            Unreviewed;      4434 AA.
AC   M9NDL5;
DT   26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 2.
DT   24-JAN-2024, entry version 80.
DE   SubName: Full=Terribly reduced optic lobes, isoform AF {ECO:0000313|EMBL:AFH07207.2};
GN   Name=trol {ECO:0000313|EMBL:AFH07207.2,
GN   ECO:0000313|FlyBase:FBgn0284408};
GN   Synonyms=anon-WO0153538.72 {ECO:0000313|EMBL:AFH07207.2},
GN   BcDNA:GM02481 {ECO:0000313|EMBL:AFH07207.2}, CG12497
GN   {ECO:0000313|EMBL:AFH07207.2}, CG33675 {ECO:0000313|EMBL:AFH07207.2},
GN   CG7981 {ECO:0000313|EMBL:AFH07207.2}, CT23996
GN   {ECO:0000313|EMBL:AFH07207.2}, Dmel\CG33950
GN   {ECO:0000313|EMBL:AFH07207.2}, EG:BACR25B3.1
GN   {ECO:0000313|EMBL:AFH07207.2}, EG:BACR25B3.10
GN   {ECO:0000313|EMBL:AFH07207.2}, EG:BACR25B3.11
GN   {ECO:0000313|EMBL:AFH07207.2}, EG:BACR25B3.2
GN   {ECO:0000313|EMBL:AFH07207.2}, GC7891 {ECO:0000313|EMBL:AFH07207.2},
GN   l(1)3Ac {ECO:0000313|EMBL:AFH07207.2}, l(1)9-96
GN   {ECO:0000313|EMBL:AFH07207.2}, l(1)G0019
GN   {ECO:0000313|EMBL:AFH07207.2}, l(1)G0021
GN   {ECO:0000313|EMBL:AFH07207.2}, l(1)G0023
GN   {ECO:0000313|EMBL:AFH07207.2}, l(1)G0181
GN   {ECO:0000313|EMBL:AFH07207.2}, l(1)G0211
GN   {ECO:0000313|EMBL:AFH07207.2}, l(1)G0271
GN   {ECO:0000313|EMBL:AFH07207.2}, l(1)G0374
GN   {ECO:0000313|EMBL:AFH07207.2}, l(1)G0412
GN   {ECO:0000313|EMBL:AFH07207.2}, l(1)trol {ECO:0000313|EMBL:AFH07207.2},
GN   l(1)VA51 {ECO:0000313|EMBL:AFH07207.2}, l(1)zw1
GN   {ECO:0000313|EMBL:AFH07207.2}, l(1)zwl {ECO:0000313|EMBL:AFH07207.2},
GN   MRE7 {ECO:0000313|EMBL:AFH07207.2}, Pcan
GN   {ECO:0000313|EMBL:AFH07207.2}, pcan {ECO:0000313|EMBL:AFH07207.2}, Pcn
GN   {ECO:0000313|EMBL:AFH07207.2}, TROL {ECO:0000313|EMBL:AFH07207.2},
GN   Trol {ECO:0000313|EMBL:AFH07207.2}, Trol-A
GN   {ECO:0000313|EMBL:AFH07207.2}, Trol-B {ECO:0000313|EMBL:AFH07207.2},
GN   Troll {ECO:0000313|EMBL:AFH07207.2}, troll
GN   {ECO:0000313|EMBL:AFH07207.2}, ZW-1 {ECO:0000313|EMBL:AFH07207.2},
GN   zw-1 {ECO:0000313|EMBL:AFH07207.2}, zw1 {ECO:0000313|EMBL:AFH07207.2};
GN   ORFNames=CG33950 {ECO:0000313|EMBL:AFH07207.2,
GN   ECO:0000313|FlyBase:FBgn0284408}, Dmel_CG33950
GN   {ECO:0000313|EMBL:AFH07207.2};
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227 {ECO:0000313|EMBL:AFH07207.2, ECO:0000313|Proteomes:UP000000803};
RN   [1] {ECO:0000313|EMBL:AFH07207.2, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A.,
RA   An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA   Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E.,
RA   Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C.,
RA   Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A.,
RA   Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C.,
RA   Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G.,
RA   Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.,
RA   Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2] {ECO:0000313|EMBL:AFH07207.2, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537568;
RA   Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA   Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA   George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA   Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA   Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA   Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT   "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster
RT   euchromatic genome sequence.";
RL   Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN   [3] {ECO:0000313|EMBL:AFH07207.2, ECO:0000313|Proteomes:UP000000803}
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [4] {ECO:0000313|EMBL:AFH07207.2, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537573;
RA   Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA   Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M.,
RA   Celniker S.E.;
RT   "The transposable elements of the Drosophila melanogaster euchromatin: a
RT   genomics perspective.";
RL   Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
RN   [5] {ECO:0000313|EMBL:AFH07207.2, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537574;
RA   Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA   Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA   Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA   Karpen G.H.;
RT   "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.";
RL   Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN   [6] {ECO:0000313|EMBL:AFH07207.2, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA   Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA   Ashburner M., Anxolabehere D.;
RT   "Combined evidence annotation of transposable elements in genome
RT   sequences.";
RL   PLoS Comput. Biol. 1:166-175(2005).
RN   [7] {ECO:0000313|EMBL:AFH07207.2, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=17569856; DOI=10.1126/science.1139815;
RA   Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT   "The Release 5.1 annotation of Drosophila melanogaster heterochromatin.";
RL   Science 316:1586-1591(2007).
RN   [8] {ECO:0000313|EMBL:AFH07207.2, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=17569867; DOI=10.1126/science.1139816;
RA   Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA   Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA   Dimitri P., Karpen G.H., Celniker S.E.;
RT   "Sequence finishing and mapping of Drosophila melanogaster
RT   heterochromatin.";
RL   Science 316:1625-1628(2007).
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   EMBL; AE014298; AFH07207.2; -; Genomic_DNA.
DR   RefSeq; NP_001245493.2; NM_001258564.2.
DR   EnsemblMetazoa; FBtr0342806; FBpp0309642; FBgn0284408.
DR   GeneID; 45320; -.
DR   AGR; FB:FBgn0284408; -.
DR   CTD; 45320; -.
DR   FlyBase; FBgn0284408; trol.
DR   VEuPathDB; VectorBase:FBgn0284408; -.
DR   GeneTree; ENSGT00940000156670; -.
DR   OrthoDB; 2877710at2759; -.
DR   BioGRID-ORCS; 45320; 0 hits in 3 CRISPR screens.
DR   ChiTaRS; trol; fly.
DR   GenomeRNAi; 45320; -.
DR   Proteomes; UP000000803; Chromosome X.
DR   Bgee; FBgn0284408; Expressed in oviduct (Drosophila) and 54 other cell types or tissues.
DR   ExpressionAtlas; M9NDL5; baseline and differential.
DR   GO; GO:0005604; C:basement membrane; IEA:UniProt.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR   GO; GO:0007415; P:defasciculation of motor neuron axon; IMP:FlyBase.
DR   GO; GO:0045199; P:maintenance of epithelial cell apical/basal polarity; IMP:FlyBase.
DR   GO; GO:0008045; P:motor neuron axon guidance; IMP:FlyBase.
DR   GO; GO:2001262; P:positive regulation of semaphorin-plexin signaling pathway; IGI:FlyBase.
DR   GO; GO:0072347; P:response to anesthetic; IMP:FlyBase.
DR   CDD; cd00054; EGF_CA; 2.
DR   CDD; cd00055; EGF_Lam; 4.
DR   CDD; cd00096; Ig; 1.
DR   CDD; cd05743; Ig_Perlecan_like; 1.
DR   CDD; cd00110; LamG; 3.
DR   CDD; cd00112; LDLa; 19.
DR   Gene3D; 2.60.120.200; -; 3.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 13.
DR   Gene3D; 2.10.25.10; Laminin; 6.
DR   Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 20.
DR   Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 2.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR013151; Immunoglobulin.
DR   InterPro; IPR001791; Laminin_G.
DR   InterPro; IPR000034; Laminin_IV.
DR   InterPro; IPR036055; LDL_receptor-like_sf.
DR   InterPro; IPR023415; LDLR_class-A_CS.
DR   InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR   InterPro; IPR002049; LE_dom.
DR   PANTHER; PTHR24270:SF8; CUB AND LDLA DOMAIN, ISOFORM A-RELATED; 1.
DR   PANTHER; PTHR24270; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED; 1.
DR   Pfam; PF00008; EGF; 1.
DR   Pfam; PF07679; I-set; 2.
DR   Pfam; PF00047; ig; 2.
DR   Pfam; PF13895; Ig_2; 1.
DR   Pfam; PF13927; Ig_3; 7.
DR   Pfam; PF00052; Laminin_B; 3.
DR   Pfam; PF00053; Laminin_EGF; 7.
DR   Pfam; PF00054; Laminin_G_1; 1.
DR   Pfam; PF02210; Laminin_G_2; 2.
DR   Pfam; PF00057; Ldl_recept_a; 16.
DR   PRINTS; PR00261; LDLRECEPTOR.
DR   SMART; SM00181; EGF; 8.
DR   SMART; SM00180; EGF_Lam; 6.
DR   SMART; SM00409; IG; 13.
DR   SMART; SM00408; IGc2; 13.
DR   SMART; SM00281; LamB; 3.
DR   SMART; SM00282; LamG; 3.
DR   SMART; SM00192; LDLa; 20.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 3.
DR   SUPFAM; SSF57196; EGF/Laminin; 4.
DR   SUPFAM; SSF48726; Immunoglobulin; 13.
DR   SUPFAM; SSF57424; LDL receptor-like module; 19.
DR   PROSITE; PS00022; EGF_1; 4.
DR   PROSITE; PS01186; EGF_2; 2.
DR   PROSITE; PS50026; EGF_3; 3.
DR   PROSITE; PS01248; EGF_LAM_1; 4.
DR   PROSITE; PS50027; EGF_LAM_2; 2.
DR   PROSITE; PS50835; IG_LIKE; 12.
DR   PROSITE; PS50025; LAM_G_DOMAIN; 3.
DR   PROSITE; PS51115; LAMININ_IVA; 3.
DR   PROSITE; PS01209; LDLRA_1; 9.
DR   PROSITE; PS50068; LDLRA_2; 20.
PE   1: Evidence at protein level;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW   ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW   Laminin EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00460};
KW   Proteomics identification {ECO:0007829|PeptideAtlas:M9NDL5};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000803}.
FT   DOMAIN          1256..1343
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          1480..1569
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          1622..1800
FT                   /note="Laminin IV type A"
FT                   /evidence="ECO:0000259|PROSITE:PS51115"
FT   DOMAIN          1856..1911
FT                   /note="Laminin EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50027"
FT   DOMAIN          1990..2171
FT                   /note="Laminin IV type A"
FT                   /evidence="ECO:0000259|PROSITE:PS51115"
FT   DOMAIN          2206..2255
FT                   /note="Laminin EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50027"
FT   DOMAIN          2346..2521
FT                   /note="Laminin IV type A"
FT                   /evidence="ECO:0000259|PROSITE:PS51115"
FT   DOMAIN          2660..2751
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          2762..2844
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          2856..2947
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          2960..3042
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          3049..3136
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          3138..3225
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          3345..3429
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          3440..3526
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          3544..3637
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          3642..3724
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          3730..3907
FT                   /note="Laminin G"
FT                   /evidence="ECO:0000259|PROSITE:PS50025"
FT   DOMAIN          3903..3941
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          3943..3978
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          3987..4161
FT                   /note="Laminin G"
FT                   /evidence="ECO:0000259|PROSITE:PS50025"
FT   DOMAIN          4195..4231
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          4237..4419
FT                   /note="Laminin G"
FT                   /evidence="ECO:0000259|PROSITE:PS50025"
FT   REGION          129..173
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          438..488
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          3228..3262
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        448..484
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        3228..3244
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        3245..3262
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        386..401
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        425..440
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        492..504
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        499..517
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        551..566
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        576..588
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        583..601
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        595..610
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        684..699
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        781..799
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        832..847
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        862..874
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        869..887
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        881..896
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        916..928
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        923..941
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        935..950
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        975..990
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        993..1005
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        1000..1018
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        1012..1027
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        1054..1066
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        1061..1079
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        1121..1136
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        1145..1163
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        1157..1172
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        1173..1185
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        1180..1198
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        1192..1207
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        1213..1225
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        1220..1238
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        1232..1247
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        1360..1372
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        1367..1385
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        1379..1394
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        1400..1412
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        1407..1425
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        1419..1434
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        1443..1455
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        1450..1468
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        1462..1477
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        1882..1891
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT   DISULFID        2225..2234
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT   DISULFID        3912..3929
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        3931..3940
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        3947..3957
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        3968..3977
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        4221..4230
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        4392..4419
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00122"
SQ   SEQUENCE   4434 AA;  491675 MW;  8065639E971B90F7 CRC64;
     MMGSPGSQAS AIATSVGIRS GRRGQAGGSL LLRLLAVTFV LAACHAPLLT NAKQISNLGD
     DQDFMLADDE SLQGINDSEW QLMGDDIDDG LLDDVDETLK PMETKSEEED LPTGNWFSQS
     VHRVRRSINR LFGSDDNQER GRRQQRERSQ RNRDAINRQK ELRRRQKEDH NRWKQMRMER
     QLEKQRLVKR TNHVVFNRAT DPRKRASDLY DENEASGYHE EDTTLYRTYF VVNEPYDNEY
     RDRESVQFQN LQKLLDDDLR NFFHSNYEGN DDEEQEIRST LERVEPTNDN FKIRVQLRIE
     LPTSVNDFGS KLQQQLNVYN RIENLSAATD GVFSFTESSD IEEEAIDVTL PQEEVEGSGS
     DDSSCRGDAT FTCPRSGKTI CDEMRCDREI QCPDGEDEEY CNYPNVCTED QFKCDDKCLE
     LKKRCDGSID CLDQTDEAGC INAPEPEPEP EPEPEPEPES EPEAEPEPEP EPEPESEPEQ
     EPEPQVPEAN ECQANEFRCN NGDCIDARKR CNNVSDCSEG EDENEECPAA CSGMEYQCRD
     GTRCISVSQQ CDGHSDCSDG DDEEHCDGSG YDSEECRFDE FHCGTGECIP MRQVCDNIYD
     CNDYSDEVNC VEGEEEDRVG IPIGHQPWRP ASKHDDWLHE MDTSEYQVYQ PSNVYEKANS
     QNPCASNQFR CTTSNVCIPL HLRCDGFYHC NDMSDEKSCE QYQRHTTTRR PLTLATPTSR
     ITTQGPGLLE RRNTTTATEA SRWPWATKTT TIATTTSNPI TTVGVANSPP QTCLENIEFA
     CHNRDCISIE SVCDGIPDCG RNEDEDDALC KCSGDKYKCQ RGGGCIPKSQ VCDGKPQCHD
     RSDESACHLH GRLNKTRLGV KCLESQYQCG DGSCISGYKR CNGIHDCADA SDEYNCIYDY
     EDTYDTDPNN NPLNECDILE FECDYSQCLP LEKKCDGYAD CEDMSDELEC QSYTDHCLES
     EFECDSYCLP RDQLCNGIPN CQDGSDERNC TFCREDAYLC NTGECVADNQ RCNGIADCAD
     GSDERHCETN NHYPTQNVNV IRPKLGPNPI PKSCRPHEWQ CANLECIDSS LQCNEIKDCS
     DGSDEELSVC FGTATTRLKP SDCSPEQFYC DESCYNRSVR CNGHVDCSDG SDEVGCSLPC
     PQHQCPSGRC YTESERCDRH RHCEDGSDEA NCCYANQFRC NNGDCVSGSA PCNGYSECSD
     HSDELNCGGT QECLPNQFRC NSGQCVSSSV RCNGRTDCQD SSDEQNCAAD SNDRRPNQLN
     LKTYPDSQII KESREVIFRC RDEGPARAKV KWSRPGGRPL PPGFTDRNGR LEIPNIRVED
     AGTYVCEAVG YASYIPGQQV TVNLNVERYN DVGSRPESAC TEYQATCMNG ECIDKSSICD
     GNPDCSDASD EQSCSLGLKC QPNQFMCSNS KCVDRTWRCD GENDCGDNSD ETSCDPEPSG
     APCRYNEFQC RSGHCIPKSF QCDNVPDCTD GTDEVGCMAP LPIRPPPQSV SLLEYEVLEL
     TCVATGTPTP TIVWRLNWGH VPDKCESKSY GGTGTLRCPD MRPQDSGAYS CEIINTRGTH
     FVNPDTIVTV RPVRTDVCEA GFFNMLARKA EECVQCFCFG VAKACDSANL FTYAIHPPIL
     SHRVVSVELS PLRQIVINEA APGQDLLTLL HGVQFRATNV HFSGRETPYL ALPADYMGNQ
     LKSYGGNLRY EVNYRGSGRP VNGPDVIITG NRFTLTYRVR TQPGQNNRVS IPFVPGGWQK
     PDGRKASREE IMMILANVDN ILIRLGYLDS TAREVDLINI ALDSAGTADK GLGSASLVEK
     CQCPPGYVGD SCESCASGYV RQPGGPWLGH CVPFIPDSCP SGTYGDPRRG VPCKECPCPL
     TGSNNFASGC QQSPDGDVVC RCNEGYTGRR CEQCAAGYQG NPLAAGGICR RIPDTSCNVD
     GTYSVHSNGT CQCKDSVIGE QCDTCKSKSF HLNSFTYTGC IECFCSGVGL DCDSSTWYRD
     QVTSTFGRSR VDHGFVLVTN YMQPTPDTVP VSMAAEPNAL SFIGSADQSG NTLYWSLPAA
     FLGNKLSSYG GKLTYTLSYS PLPNGIMSRN SAPDVVIKSG EDLRLIHYRK SQVVPSVANT
     YSVEIKESAW QRGDEVVANR EHVLMALSDI TAIYIKATYT TSTKEASLRQ VTLDVATPTN
     LGTPRAVEVE QCRCPEGYLG LSCEQCAPGY ARDPEGGIYL GLCRPCECNG HSKYCNSDTG
     DCEECSDNTE GPSCERCAAG YVGDATRGTI YDCQPDEGYP IPSPPAPGNQ TLECTAYCQI
     EGIYDCRGNE CLCKRNVIGD QCDQCRPGTY GLSAQNQDGC KECYCSGLAS QCRSAALYRQ
     LIPVDFILNA PLITDESGAV QDTENLIPDI SRNMYTYTHT SYLPKYWSLR GSVLGNQLFS
     YGGRLSYSLI VESYGNYERG HDIVLIGNGL KLIWSRPDGN ENQEEYNVRL HEDEQWTRQD
     RESARPASRS DFMTVLSDLQ HILIRATPRV PTQSTSIGNV ILESAVTTRT PGATHASDIE
     LCQCPSGYVG TSCESCAPLH YRDASGSCSL CPCDVSNTES CDLVSGGYVE CRCKARWKGD
     RCREIDTSPI IEDPPQICDL SRGFCCSGFQ FDIAPNETIS FNDTLQIYKG NRIIGNMTKL
     RYGCPSRDTN DPTDIGTEDP VLTQIIVSIQ KPEITIVPVG GSMTLSCSGR MRWSNSPVIV
     NWYKENSRLP ENVEVQGGNL YLYDLQVSDS GVYICQAVNN ETASVFKDTV SITITKKDQL
     SPAEIVNLPS HVTFEEYVNN EIICEVLGNP APRVTWARVD GHADAQSTRT YDNRLIFDSP
     RKSDEGRYRC QAENDQNRDE KYVIVYVQSN PPQPPPQQDR LYITPEEING LAGESFQLNC
     QFTSVASLRY DWSHNGRSLS SSPARNVEIR GNTLEVRDAS ESDSGVYTCV AYDVRTRRNF
     TESARVNIDR REEQPFGNKP IIESLEQNIL IIQGEDYSIT CEASGSPYPS IKWAKVHDFM
     PENVHISGNV LTIYGARFEN RGVYSCVAEN DHGSDLSSTS IDIEPRERPS VKIVSAPLQT
     FSVGAPASLY CTVEGIPDPT VEWVRVDGQP LSPRHKIQSP GYMVIDDIQL EDSGDYECRA
     KNIVGEATGV ATITVQEPTL VQIIPDNRDL RLTEGDELSL TCVGSGVPNP EVEWVNEMAL
     KRDLYSPPSN TAILKIYRVT KADAGIYTCH GKNEAGSDEA HVRVEVQERR GDIGGVDDDS
     DRDPINYNPP QQQNPGIHQP GSNQLLATDI GDNVTLTCDM FQPLNTRWER VDGAPLPRNA
     YTIKNRLEIV RVEQQNLGQY RCNGIGRDGN VKTYFVKELV LMPLPRIRFY PNIPLTVEAG
     QNLDVHCQVE NVRPEDVHWS TDNNRPLPSS VRIVGSVLRF VSITQAAAGE YRCSAFNQYG
     NRSQIARVAV KKPADFHQVP QSQLQRHREG ENIQLQCTVT DQYGVRAQDN VEFNWFRDDR
     RPLPNNARTD SQILVLTNLR PEDAGRYICN SYDVDRGQQL PEVSIDLQVL TATPPPNSPI
     YLPPQLPAKS RDYSLKLDDQ SSNLRAGEST DVECYSSDDT YTDVVWERSD GAPLSNNVRQ
     VGNRLVISNV SPSDAGNYVC KCKTDEGDLY TTSYKLEVED QPHELKSSKI VYAKVGANAD
     LQCGADESRQ PTYRWSRQYG QLQAGRSLMN EKLSLDSVQA NDAGTYICTA QYADGETADF
     PNILVVTGAI PQFRQEPRSY MSFPTLPNSS FKFNFELTFR PENGDGLLLF NGQTRGSGDY
     IALSLKDRYA EFRFDFGGKP MLVRAEEPLA LNEWHTVRVS RFKRDGYIQV DEQHPVAFPT
     LQQIPQLDLI EDLYIGGVPN WELLPADAVS QQVGFVGCIS RLTLQGRTVE LIREAKYKEG
     ITDCRPCAQG PCQNKGVCLE SQTEQAYTCI CQPGWTGRDC AIEGTQCTPG VCGAGRCENT
     ENDMECLCPL NRSGDRCQYN EILNEHSLNF KGNSFAAYGT PKVTKVNITL SVRPASLEDS
     VILYTAESTL PSGDYLALVL RGGHAELLIN TAARLDPVVV RSAEPLPLNR WTRIEIRRRL
     GEGILRVGDG PERKAKAPGS DRILSLKTHL YVGGYDRSTV KVNRDVNITK GFDGCISRLY
     NFQKPVNLLA DIKDAANIQS CGETNMIGGD EDSDNEPPVP PPTPDVHENE LQPYAMAPCA
     SDPCENGGSC SEQEDVAVCS CPFGFSGKHC QEHLQLGFNA SFRGDGYVEL NRSHFQPALE
     QSYTSMGIVF TTNKPNGLLF WWGQEAGEEY TGQDFIAAAV VDGYVEYSMR LDGEEAVIRN
     SDIRVDNGER HIVIAKRDEN TAILEVDRML HSGETRPTSK KSMKLPGNVF VGGAPDLEVF
     TGFRYKHNLN GCIVVVEGET VGQINLSSAA VNGVNANVCP ANDDPLGGTE PPVV
//
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