ID M9NDL5_DROME Unreviewed; 4434 AA.
AC M9NDL5;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 2.
DT 24-JAN-2024, entry version 80.
DE SubName: Full=Terribly reduced optic lobes, isoform AF {ECO:0000313|EMBL:AFH07207.2};
GN Name=trol {ECO:0000313|EMBL:AFH07207.2,
GN ECO:0000313|FlyBase:FBgn0284408};
GN Synonyms=anon-WO0153538.72 {ECO:0000313|EMBL:AFH07207.2},
GN BcDNA:GM02481 {ECO:0000313|EMBL:AFH07207.2}, CG12497
GN {ECO:0000313|EMBL:AFH07207.2}, CG33675 {ECO:0000313|EMBL:AFH07207.2},
GN CG7981 {ECO:0000313|EMBL:AFH07207.2}, CT23996
GN {ECO:0000313|EMBL:AFH07207.2}, Dmel\CG33950
GN {ECO:0000313|EMBL:AFH07207.2}, EG:BACR25B3.1
GN {ECO:0000313|EMBL:AFH07207.2}, EG:BACR25B3.10
GN {ECO:0000313|EMBL:AFH07207.2}, EG:BACR25B3.11
GN {ECO:0000313|EMBL:AFH07207.2}, EG:BACR25B3.2
GN {ECO:0000313|EMBL:AFH07207.2}, GC7891 {ECO:0000313|EMBL:AFH07207.2},
GN l(1)3Ac {ECO:0000313|EMBL:AFH07207.2}, l(1)9-96
GN {ECO:0000313|EMBL:AFH07207.2}, l(1)G0019
GN {ECO:0000313|EMBL:AFH07207.2}, l(1)G0021
GN {ECO:0000313|EMBL:AFH07207.2}, l(1)G0023
GN {ECO:0000313|EMBL:AFH07207.2}, l(1)G0181
GN {ECO:0000313|EMBL:AFH07207.2}, l(1)G0211
GN {ECO:0000313|EMBL:AFH07207.2}, l(1)G0271
GN {ECO:0000313|EMBL:AFH07207.2}, l(1)G0374
GN {ECO:0000313|EMBL:AFH07207.2}, l(1)G0412
GN {ECO:0000313|EMBL:AFH07207.2}, l(1)trol {ECO:0000313|EMBL:AFH07207.2},
GN l(1)VA51 {ECO:0000313|EMBL:AFH07207.2}, l(1)zw1
GN {ECO:0000313|EMBL:AFH07207.2}, l(1)zwl {ECO:0000313|EMBL:AFH07207.2},
GN MRE7 {ECO:0000313|EMBL:AFH07207.2}, Pcan
GN {ECO:0000313|EMBL:AFH07207.2}, pcan {ECO:0000313|EMBL:AFH07207.2}, Pcn
GN {ECO:0000313|EMBL:AFH07207.2}, TROL {ECO:0000313|EMBL:AFH07207.2},
GN Trol {ECO:0000313|EMBL:AFH07207.2}, Trol-A
GN {ECO:0000313|EMBL:AFH07207.2}, Trol-B {ECO:0000313|EMBL:AFH07207.2},
GN Troll {ECO:0000313|EMBL:AFH07207.2}, troll
GN {ECO:0000313|EMBL:AFH07207.2}, ZW-1 {ECO:0000313|EMBL:AFH07207.2},
GN zw-1 {ECO:0000313|EMBL:AFH07207.2}, zw1 {ECO:0000313|EMBL:AFH07207.2};
GN ORFNames=CG33950 {ECO:0000313|EMBL:AFH07207.2,
GN ECO:0000313|FlyBase:FBgn0284408}, Dmel_CG33950
GN {ECO:0000313|EMBL:AFH07207.2};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AFH07207.2, ECO:0000313|Proteomes:UP000000803};
RN [1] {ECO:0000313|EMBL:AFH07207.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A.,
RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E.,
RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C.,
RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A.,
RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C.,
RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G.,
RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.,
RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000313|EMBL:AFH07207.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537568;
RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster
RT euchromatic genome sequence.";
RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN [3] {ECO:0000313|EMBL:AFH07207.2, ECO:0000313|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4] {ECO:0000313|EMBL:AFH07207.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537573;
RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M.,
RA Celniker S.E.;
RT "The transposable elements of the Drosophila melanogaster euchromatin: a
RT genomics perspective.";
RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
RN [5] {ECO:0000313|EMBL:AFH07207.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537574;
RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA Karpen G.H.;
RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.";
RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN [6] {ECO:0000313|EMBL:AFH07207.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA Ashburner M., Anxolabehere D.;
RT "Combined evidence annotation of transposable elements in genome
RT sequences.";
RL PLoS Comput. Biol. 1:166-175(2005).
RN [7] {ECO:0000313|EMBL:AFH07207.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569856; DOI=10.1126/science.1139815;
RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin.";
RL Science 316:1586-1591(2007).
RN [8] {ECO:0000313|EMBL:AFH07207.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569867; DOI=10.1126/science.1139816;
RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA Dimitri P., Karpen G.H., Celniker S.E.;
RT "Sequence finishing and mapping of Drosophila melanogaster
RT heterochromatin.";
RL Science 316:1625-1628(2007).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; AE014298; AFH07207.2; -; Genomic_DNA.
DR RefSeq; NP_001245493.2; NM_001258564.2.
DR EnsemblMetazoa; FBtr0342806; FBpp0309642; FBgn0284408.
DR GeneID; 45320; -.
DR AGR; FB:FBgn0284408; -.
DR CTD; 45320; -.
DR FlyBase; FBgn0284408; trol.
DR VEuPathDB; VectorBase:FBgn0284408; -.
DR GeneTree; ENSGT00940000156670; -.
DR OrthoDB; 2877710at2759; -.
DR BioGRID-ORCS; 45320; 0 hits in 3 CRISPR screens.
DR ChiTaRS; trol; fly.
DR GenomeRNAi; 45320; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0284408; Expressed in oviduct (Drosophila) and 54 other cell types or tissues.
DR ExpressionAtlas; M9NDL5; baseline and differential.
DR GO; GO:0005604; C:basement membrane; IEA:UniProt.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0007415; P:defasciculation of motor neuron axon; IMP:FlyBase.
DR GO; GO:0045199; P:maintenance of epithelial cell apical/basal polarity; IMP:FlyBase.
DR GO; GO:0008045; P:motor neuron axon guidance; IMP:FlyBase.
DR GO; GO:2001262; P:positive regulation of semaphorin-plexin signaling pathway; IGI:FlyBase.
DR GO; GO:0072347; P:response to anesthetic; IMP:FlyBase.
DR CDD; cd00054; EGF_CA; 2.
DR CDD; cd00055; EGF_Lam; 4.
DR CDD; cd00096; Ig; 1.
DR CDD; cd05743; Ig_Perlecan_like; 1.
DR CDD; cd00110; LamG; 3.
DR CDD; cd00112; LDLa; 19.
DR Gene3D; 2.60.120.200; -; 3.
DR Gene3D; 2.60.40.10; Immunoglobulins; 13.
DR Gene3D; 2.10.25.10; Laminin; 6.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 20.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013151; Immunoglobulin.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR000034; Laminin_IV.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR24270:SF8; CUB AND LDLA DOMAIN, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR24270; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED; 1.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF00047; ig; 2.
DR Pfam; PF13895; Ig_2; 1.
DR Pfam; PF13927; Ig_3; 7.
DR Pfam; PF00052; Laminin_B; 3.
DR Pfam; PF00053; Laminin_EGF; 7.
DR Pfam; PF00054; Laminin_G_1; 1.
DR Pfam; PF02210; Laminin_G_2; 2.
DR Pfam; PF00057; Ldl_recept_a; 16.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 8.
DR SMART; SM00180; EGF_Lam; 6.
DR SMART; SM00409; IG; 13.
DR SMART; SM00408; IGc2; 13.
DR SMART; SM00281; LamB; 3.
DR SMART; SM00282; LamG; 3.
DR SMART; SM00192; LDLa; 20.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 3.
DR SUPFAM; SSF57196; EGF/Laminin; 4.
DR SUPFAM; SSF48726; Immunoglobulin; 13.
DR SUPFAM; SSF57424; LDL receptor-like module; 19.
DR PROSITE; PS00022; EGF_1; 4.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS01248; EGF_LAM_1; 4.
DR PROSITE; PS50027; EGF_LAM_2; 2.
DR PROSITE; PS50835; IG_LIKE; 12.
DR PROSITE; PS50025; LAM_G_DOMAIN; 3.
DR PROSITE; PS51115; LAMININ_IVA; 3.
DR PROSITE; PS01209; LDLRA_1; 9.
DR PROSITE; PS50068; LDLRA_2; 20.
PE 1: Evidence at protein level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Laminin EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00460};
KW Proteomics identification {ECO:0007829|PeptideAtlas:M9NDL5};
KW Reference proteome {ECO:0000313|Proteomes:UP000000803}.
FT DOMAIN 1256..1343
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1480..1569
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1622..1800
FT /note="Laminin IV type A"
FT /evidence="ECO:0000259|PROSITE:PS51115"
FT DOMAIN 1856..1911
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1990..2171
FT /note="Laminin IV type A"
FT /evidence="ECO:0000259|PROSITE:PS51115"
FT DOMAIN 2206..2255
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 2346..2521
FT /note="Laminin IV type A"
FT /evidence="ECO:0000259|PROSITE:PS51115"
FT DOMAIN 2660..2751
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2762..2844
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2856..2947
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2960..3042
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3049..3136
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3138..3225
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3345..3429
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3440..3526
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3544..3637
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3642..3724
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3730..3907
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 3903..3941
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3943..3978
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3987..4161
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 4195..4231
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4237..4419
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT REGION 129..173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 438..488
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3228..3262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 448..484
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3228..3244
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3245..3262
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 386..401
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 425..440
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 492..504
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 499..517
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 551..566
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 576..588
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 583..601
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 595..610
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 684..699
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 781..799
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 832..847
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 862..874
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 869..887
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 881..896
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 916..928
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 923..941
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 935..950
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 975..990
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 993..1005
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1000..1018
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1012..1027
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1054..1066
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1061..1079
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1121..1136
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1145..1163
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1157..1172
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1173..1185
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1180..1198
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1192..1207
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1213..1225
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1220..1238
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1232..1247
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1360..1372
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1367..1385
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1379..1394
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1400..1412
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1407..1425
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1419..1434
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1443..1455
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1450..1468
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1462..1477
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1882..1891
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 2225..2234
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 3912..3929
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3931..3940
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3947..3957
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3968..3977
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4221..4230
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4392..4419
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00122"
SQ SEQUENCE 4434 AA; 491675 MW; 8065639E971B90F7 CRC64;
MMGSPGSQAS AIATSVGIRS GRRGQAGGSL LLRLLAVTFV LAACHAPLLT NAKQISNLGD
DQDFMLADDE SLQGINDSEW QLMGDDIDDG LLDDVDETLK PMETKSEEED LPTGNWFSQS
VHRVRRSINR LFGSDDNQER GRRQQRERSQ RNRDAINRQK ELRRRQKEDH NRWKQMRMER
QLEKQRLVKR TNHVVFNRAT DPRKRASDLY DENEASGYHE EDTTLYRTYF VVNEPYDNEY
RDRESVQFQN LQKLLDDDLR NFFHSNYEGN DDEEQEIRST LERVEPTNDN FKIRVQLRIE
LPTSVNDFGS KLQQQLNVYN RIENLSAATD GVFSFTESSD IEEEAIDVTL PQEEVEGSGS
DDSSCRGDAT FTCPRSGKTI CDEMRCDREI QCPDGEDEEY CNYPNVCTED QFKCDDKCLE
LKKRCDGSID CLDQTDEAGC INAPEPEPEP EPEPEPEPES EPEAEPEPEP EPEPESEPEQ
EPEPQVPEAN ECQANEFRCN NGDCIDARKR CNNVSDCSEG EDENEECPAA CSGMEYQCRD
GTRCISVSQQ CDGHSDCSDG DDEEHCDGSG YDSEECRFDE FHCGTGECIP MRQVCDNIYD
CNDYSDEVNC VEGEEEDRVG IPIGHQPWRP ASKHDDWLHE MDTSEYQVYQ PSNVYEKANS
QNPCASNQFR CTTSNVCIPL HLRCDGFYHC NDMSDEKSCE QYQRHTTTRR PLTLATPTSR
ITTQGPGLLE RRNTTTATEA SRWPWATKTT TIATTTSNPI TTVGVANSPP QTCLENIEFA
CHNRDCISIE SVCDGIPDCG RNEDEDDALC KCSGDKYKCQ RGGGCIPKSQ VCDGKPQCHD
RSDESACHLH GRLNKTRLGV KCLESQYQCG DGSCISGYKR CNGIHDCADA SDEYNCIYDY
EDTYDTDPNN NPLNECDILE FECDYSQCLP LEKKCDGYAD CEDMSDELEC QSYTDHCLES
EFECDSYCLP RDQLCNGIPN CQDGSDERNC TFCREDAYLC NTGECVADNQ RCNGIADCAD
GSDERHCETN NHYPTQNVNV IRPKLGPNPI PKSCRPHEWQ CANLECIDSS LQCNEIKDCS
DGSDEELSVC FGTATTRLKP SDCSPEQFYC DESCYNRSVR CNGHVDCSDG SDEVGCSLPC
PQHQCPSGRC YTESERCDRH RHCEDGSDEA NCCYANQFRC NNGDCVSGSA PCNGYSECSD
HSDELNCGGT QECLPNQFRC NSGQCVSSSV RCNGRTDCQD SSDEQNCAAD SNDRRPNQLN
LKTYPDSQII KESREVIFRC RDEGPARAKV KWSRPGGRPL PPGFTDRNGR LEIPNIRVED
AGTYVCEAVG YASYIPGQQV TVNLNVERYN DVGSRPESAC TEYQATCMNG ECIDKSSICD
GNPDCSDASD EQSCSLGLKC QPNQFMCSNS KCVDRTWRCD GENDCGDNSD ETSCDPEPSG
APCRYNEFQC RSGHCIPKSF QCDNVPDCTD GTDEVGCMAP LPIRPPPQSV SLLEYEVLEL
TCVATGTPTP TIVWRLNWGH VPDKCESKSY GGTGTLRCPD MRPQDSGAYS CEIINTRGTH
FVNPDTIVTV RPVRTDVCEA GFFNMLARKA EECVQCFCFG VAKACDSANL FTYAIHPPIL
SHRVVSVELS PLRQIVINEA APGQDLLTLL HGVQFRATNV HFSGRETPYL ALPADYMGNQ
LKSYGGNLRY EVNYRGSGRP VNGPDVIITG NRFTLTYRVR TQPGQNNRVS IPFVPGGWQK
PDGRKASREE IMMILANVDN ILIRLGYLDS TAREVDLINI ALDSAGTADK GLGSASLVEK
CQCPPGYVGD SCESCASGYV RQPGGPWLGH CVPFIPDSCP SGTYGDPRRG VPCKECPCPL
TGSNNFASGC QQSPDGDVVC RCNEGYTGRR CEQCAAGYQG NPLAAGGICR RIPDTSCNVD
GTYSVHSNGT CQCKDSVIGE QCDTCKSKSF HLNSFTYTGC IECFCSGVGL DCDSSTWYRD
QVTSTFGRSR VDHGFVLVTN YMQPTPDTVP VSMAAEPNAL SFIGSADQSG NTLYWSLPAA
FLGNKLSSYG GKLTYTLSYS PLPNGIMSRN SAPDVVIKSG EDLRLIHYRK SQVVPSVANT
YSVEIKESAW QRGDEVVANR EHVLMALSDI TAIYIKATYT TSTKEASLRQ VTLDVATPTN
LGTPRAVEVE QCRCPEGYLG LSCEQCAPGY ARDPEGGIYL GLCRPCECNG HSKYCNSDTG
DCEECSDNTE GPSCERCAAG YVGDATRGTI YDCQPDEGYP IPSPPAPGNQ TLECTAYCQI
EGIYDCRGNE CLCKRNVIGD QCDQCRPGTY GLSAQNQDGC KECYCSGLAS QCRSAALYRQ
LIPVDFILNA PLITDESGAV QDTENLIPDI SRNMYTYTHT SYLPKYWSLR GSVLGNQLFS
YGGRLSYSLI VESYGNYERG HDIVLIGNGL KLIWSRPDGN ENQEEYNVRL HEDEQWTRQD
RESARPASRS DFMTVLSDLQ HILIRATPRV PTQSTSIGNV ILESAVTTRT PGATHASDIE
LCQCPSGYVG TSCESCAPLH YRDASGSCSL CPCDVSNTES CDLVSGGYVE CRCKARWKGD
RCREIDTSPI IEDPPQICDL SRGFCCSGFQ FDIAPNETIS FNDTLQIYKG NRIIGNMTKL
RYGCPSRDTN DPTDIGTEDP VLTQIIVSIQ KPEITIVPVG GSMTLSCSGR MRWSNSPVIV
NWYKENSRLP ENVEVQGGNL YLYDLQVSDS GVYICQAVNN ETASVFKDTV SITITKKDQL
SPAEIVNLPS HVTFEEYVNN EIICEVLGNP APRVTWARVD GHADAQSTRT YDNRLIFDSP
RKSDEGRYRC QAENDQNRDE KYVIVYVQSN PPQPPPQQDR LYITPEEING LAGESFQLNC
QFTSVASLRY DWSHNGRSLS SSPARNVEIR GNTLEVRDAS ESDSGVYTCV AYDVRTRRNF
TESARVNIDR REEQPFGNKP IIESLEQNIL IIQGEDYSIT CEASGSPYPS IKWAKVHDFM
PENVHISGNV LTIYGARFEN RGVYSCVAEN DHGSDLSSTS IDIEPRERPS VKIVSAPLQT
FSVGAPASLY CTVEGIPDPT VEWVRVDGQP LSPRHKIQSP GYMVIDDIQL EDSGDYECRA
KNIVGEATGV ATITVQEPTL VQIIPDNRDL RLTEGDELSL TCVGSGVPNP EVEWVNEMAL
KRDLYSPPSN TAILKIYRVT KADAGIYTCH GKNEAGSDEA HVRVEVQERR GDIGGVDDDS
DRDPINYNPP QQQNPGIHQP GSNQLLATDI GDNVTLTCDM FQPLNTRWER VDGAPLPRNA
YTIKNRLEIV RVEQQNLGQY RCNGIGRDGN VKTYFVKELV LMPLPRIRFY PNIPLTVEAG
QNLDVHCQVE NVRPEDVHWS TDNNRPLPSS VRIVGSVLRF VSITQAAAGE YRCSAFNQYG
NRSQIARVAV KKPADFHQVP QSQLQRHREG ENIQLQCTVT DQYGVRAQDN VEFNWFRDDR
RPLPNNARTD SQILVLTNLR PEDAGRYICN SYDVDRGQQL PEVSIDLQVL TATPPPNSPI
YLPPQLPAKS RDYSLKLDDQ SSNLRAGEST DVECYSSDDT YTDVVWERSD GAPLSNNVRQ
VGNRLVISNV SPSDAGNYVC KCKTDEGDLY TTSYKLEVED QPHELKSSKI VYAKVGANAD
LQCGADESRQ PTYRWSRQYG QLQAGRSLMN EKLSLDSVQA NDAGTYICTA QYADGETADF
PNILVVTGAI PQFRQEPRSY MSFPTLPNSS FKFNFELTFR PENGDGLLLF NGQTRGSGDY
IALSLKDRYA EFRFDFGGKP MLVRAEEPLA LNEWHTVRVS RFKRDGYIQV DEQHPVAFPT
LQQIPQLDLI EDLYIGGVPN WELLPADAVS QQVGFVGCIS RLTLQGRTVE LIREAKYKEG
ITDCRPCAQG PCQNKGVCLE SQTEQAYTCI CQPGWTGRDC AIEGTQCTPG VCGAGRCENT
ENDMECLCPL NRSGDRCQYN EILNEHSLNF KGNSFAAYGT PKVTKVNITL SVRPASLEDS
VILYTAESTL PSGDYLALVL RGGHAELLIN TAARLDPVVV RSAEPLPLNR WTRIEIRRRL
GEGILRVGDG PERKAKAPGS DRILSLKTHL YVGGYDRSTV KVNRDVNITK GFDGCISRLY
NFQKPVNLLA DIKDAANIQS CGETNMIGGD EDSDNEPPVP PPTPDVHENE LQPYAMAPCA
SDPCENGGSC SEQEDVAVCS CPFGFSGKHC QEHLQLGFNA SFRGDGYVEL NRSHFQPALE
QSYTSMGIVF TTNKPNGLLF WWGQEAGEEY TGQDFIAAAV VDGYVEYSMR LDGEEAVIRN
SDIRVDNGER HIVIAKRDEN TAILEVDRML HSGETRPTSK KSMKLPGNVF VGGAPDLEVF
TGFRYKHNLN GCIVVVEGET VGQINLSSAA VNGVNANVCP ANDDPLGGTE PPVV
//