ID M9NFS1_DROME Unreviewed; 4299 AA.
AC M9NFS1;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 2.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=Terribly reduced optic lobes, isoform AQ {ECO:0000313|EMBL:AFH07213.2};
GN Name=trol {ECO:0000313|EMBL:AFH07213.2,
GN ECO:0000313|FlyBase:FBgn0284408};
GN Synonyms=anon-WO0153538.72 {ECO:0000313|EMBL:AFH07213.2},
GN BcDNA:GM02481 {ECO:0000313|EMBL:AFH07213.2}, CG12497
GN {ECO:0000313|EMBL:AFH07213.2}, CG33675 {ECO:0000313|EMBL:AFH07213.2},
GN CG7981 {ECO:0000313|EMBL:AFH07213.2}, CT23996
GN {ECO:0000313|EMBL:AFH07213.2}, Dmel\CG33950
GN {ECO:0000313|EMBL:AFH07213.2}, EG:BACR25B3.1
GN {ECO:0000313|EMBL:AFH07213.2}, EG:BACR25B3.10
GN {ECO:0000313|EMBL:AFH07213.2}, EG:BACR25B3.11
GN {ECO:0000313|EMBL:AFH07213.2}, EG:BACR25B3.2
GN {ECO:0000313|EMBL:AFH07213.2}, GC7891 {ECO:0000313|EMBL:AFH07213.2},
GN l(1)3Ac {ECO:0000313|EMBL:AFH07213.2}, l(1)9-96
GN {ECO:0000313|EMBL:AFH07213.2}, l(1)G0019
GN {ECO:0000313|EMBL:AFH07213.2}, l(1)G0021
GN {ECO:0000313|EMBL:AFH07213.2}, l(1)G0023
GN {ECO:0000313|EMBL:AFH07213.2}, l(1)G0181
GN {ECO:0000313|EMBL:AFH07213.2}, l(1)G0211
GN {ECO:0000313|EMBL:AFH07213.2}, l(1)G0271
GN {ECO:0000313|EMBL:AFH07213.2}, l(1)G0374
GN {ECO:0000313|EMBL:AFH07213.2}, l(1)G0412
GN {ECO:0000313|EMBL:AFH07213.2}, l(1)trol {ECO:0000313|EMBL:AFH07213.2},
GN l(1)VA51 {ECO:0000313|EMBL:AFH07213.2}, l(1)zw1
GN {ECO:0000313|EMBL:AFH07213.2}, l(1)zwl {ECO:0000313|EMBL:AFH07213.2},
GN MRE7 {ECO:0000313|EMBL:AFH07213.2}, Pcan
GN {ECO:0000313|EMBL:AFH07213.2}, pcan {ECO:0000313|EMBL:AFH07213.2}, Pcn
GN {ECO:0000313|EMBL:AFH07213.2}, TROL {ECO:0000313|EMBL:AFH07213.2},
GN Trol {ECO:0000313|EMBL:AFH07213.2}, Trol-A
GN {ECO:0000313|EMBL:AFH07213.2}, Trol-B {ECO:0000313|EMBL:AFH07213.2},
GN Troll {ECO:0000313|EMBL:AFH07213.2}, troll
GN {ECO:0000313|EMBL:AFH07213.2}, ZW-1 {ECO:0000313|EMBL:AFH07213.2},
GN zw-1 {ECO:0000313|EMBL:AFH07213.2}, zw1 {ECO:0000313|EMBL:AFH07213.2};
GN ORFNames=CG33950 {ECO:0000313|EMBL:AFH07213.2,
GN ECO:0000313|FlyBase:FBgn0284408}, Dmel_CG33950
GN {ECO:0000313|EMBL:AFH07213.2};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AFH07213.2, ECO:0000313|Proteomes:UP000000803};
RN [1] {ECO:0000313|EMBL:AFH07213.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A.,
RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E.,
RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C.,
RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A.,
RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C.,
RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G.,
RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.,
RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000313|EMBL:AFH07213.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537568;
RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster
RT euchromatic genome sequence.";
RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN [3] {ECO:0000313|EMBL:AFH07213.2, ECO:0000313|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4] {ECO:0000313|EMBL:AFH07213.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537573;
RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M.,
RA Celniker S.E.;
RT "The transposable elements of the Drosophila melanogaster euchromatin: a
RT genomics perspective.";
RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
RN [5] {ECO:0000313|EMBL:AFH07213.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537574;
RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA Karpen G.H.;
RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.";
RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN [6] {ECO:0000313|EMBL:AFH07213.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA Ashburner M., Anxolabehere D.;
RT "Combined evidence annotation of transposable elements in genome
RT sequences.";
RL PLoS Comput. Biol. 1:166-175(2005).
RN [7] {ECO:0000313|EMBL:AFH07213.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569856; DOI=10.1126/science.1139815;
RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin.";
RL Science 316:1586-1591(2007).
RN [8] {ECO:0000313|EMBL:AFH07213.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569867; DOI=10.1126/science.1139816;
RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA Dimitri P., Karpen G.H., Celniker S.E.;
RT "Sequence finishing and mapping of Drosophila melanogaster
RT heterochromatin.";
RL Science 316:1625-1628(2007).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; AE014298; AFH07213.2; -; Genomic_DNA.
DR RefSeq; NP_001245499.2; NM_001258570.2.
DR EnsemblMetazoa; FBtr0342816; FBpp0309652; FBgn0284408.
DR GeneID; 45320; -.
DR AGR; FB:FBgn0284408; -.
DR CTD; 45320; -.
DR FlyBase; FBgn0284408; trol.
DR VEuPathDB; VectorBase:FBgn0284408; -.
DR GeneTree; ENSGT00940000156670; -.
DR OrthoDB; 2877710at2759; -.
DR BioGRID-ORCS; 45320; 0 hits in 3 CRISPR screens.
DR ChiTaRS; trol; fly.
DR GenomeRNAi; 45320; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0284408; Expressed in oviduct (Drosophila) and 54 other cell types or tissues.
DR ExpressionAtlas; M9NFS1; baseline and differential.
DR GO; GO:0005604; C:basement membrane; ISS:FlyBase.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0007415; P:defasciculation of motor neuron axon; IMP:FlyBase.
DR GO; GO:0045199; P:maintenance of epithelial cell apical/basal polarity; IMP:FlyBase.
DR GO; GO:0008045; P:motor neuron axon guidance; IMP:FlyBase.
DR GO; GO:2001262; P:positive regulation of semaphorin-plexin signaling pathway; IGI:FlyBase.
DR GO; GO:0072347; P:response to anesthetic; IMP:FlyBase.
DR CDD; cd00054; EGF_CA; 2.
DR CDD; cd00055; EGF_Lam; 4.
DR CDD; cd00096; Ig; 1.
DR CDD; cd05743; Ig_Perlecan_like; 1.
DR CDD; cd00110; LamG; 3.
DR CDD; cd00112; LDLa; 17.
DR Gene3D; 2.60.120.200; -; 3.
DR Gene3D; 2.60.40.10; Immunoglobulins; 13.
DR Gene3D; 2.10.25.10; Laminin; 6.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 18.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013151; Immunoglobulin.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR000034; Laminin_IV.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR12231; CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN; 1.
DR PANTHER; PTHR12231:SF253; NEURAL CELL ADHESION MOLECULE; 1.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF00047; ig; 2.
DR Pfam; PF13895; Ig_2; 1.
DR Pfam; PF13927; Ig_3; 7.
DR Pfam; PF00052; Laminin_B; 3.
DR Pfam; PF00053; Laminin_EGF; 7.
DR Pfam; PF00054; Laminin_G_1; 1.
DR Pfam; PF02210; Laminin_G_2; 2.
DR Pfam; PF00057; Ldl_recept_a; 14.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 8.
DR SMART; SM00180; EGF_Lam; 6.
DR SMART; SM00409; IG; 13.
DR SMART; SM00408; IGc2; 13.
DR SMART; SM00281; LamB; 3.
DR SMART; SM00282; LamG; 3.
DR SMART; SM00192; LDLa; 18.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 3.
DR SUPFAM; SSF57196; EGF/Laminin; 4.
DR SUPFAM; SSF48726; Immunoglobulin; 13.
DR SUPFAM; SSF57424; LDL receptor-like module; 17.
DR PROSITE; PS00022; EGF_1; 4.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS01248; EGF_LAM_1; 4.
DR PROSITE; PS50027; EGF_LAM_2; 2.
DR PROSITE; PS50835; IG_LIKE; 12.
DR PROSITE; PS50025; LAM_G_DOMAIN; 3.
DR PROSITE; PS51115; LAMININ_IVA; 3.
DR PROSITE; PS01209; LDLRA_1; 9.
DR PROSITE; PS50068; LDLRA_2; 18.
PE 1: Evidence at protein level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Laminin EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00460};
KW Proteomics identification {ECO:0007829|PeptideAtlas:M9NFS1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000803}.
FT DOMAIN 1183..1270
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1407..1496
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1549..1727
FT /note="Laminin IV type A"
FT /evidence="ECO:0000259|PROSITE:PS51115"
FT DOMAIN 1783..1838
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1917..2098
FT /note="Laminin IV type A"
FT /evidence="ECO:0000259|PROSITE:PS51115"
FT DOMAIN 2133..2182
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 2273..2448
FT /note="Laminin IV type A"
FT /evidence="ECO:0000259|PROSITE:PS51115"
FT DOMAIN 2525..2616
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2627..2709
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2721..2812
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2825..2907
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2914..3001
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3003..3090
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3210..3294
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3305..3391
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3409..3502
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3507..3589
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3595..3772
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 3768..3806
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3808..3843
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3852..4026
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 4060..4096
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4102..4284
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT REGION 129..173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 438..488
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3093..3127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 448..484
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3093..3109
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3110..3127
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 386..401
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 425..440
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 492..504
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 499..517
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 551..566
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 576..588
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 583..601
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 595..610
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 684..699
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 781..799
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 832..847
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 862..874
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 869..887
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 881..896
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 916..928
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 923..941
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 935..950
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 981..993
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 988..1006
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1048..1063
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1072..1090
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1084..1099
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1100..1112
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1107..1125
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1119..1134
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1140..1152
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1147..1165
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1159..1174
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1287..1299
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1294..1312
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1306..1321
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1327..1339
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1334..1352
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1346..1361
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1370..1382
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1377..1395
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1389..1404
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1809..1818
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 2152..2161
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 3777..3794
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3796..3805
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3812..3822
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3833..3842
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4086..4095
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4257..4284
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00122"
SQ SEQUENCE 4299 AA; 476604 MW; EAA6B75CC641715D CRC64;
MMGSPGSQAS AIATSVGIRS GRRGQAGGSL LLRLLAVTFV LAACHAPLLT NAKQISNLGD
DQDFMLADDE SLQGINDSEW QLMGDDIDDG LLDDVDETLK PMETKSEEED LPTGNWFSQS
VHRVRRSINR LFGSDDNQER GRRQQRERSQ RNRDAINRQK ELRRRQKEDH NRWKQMRMER
QLEKQRLVKR TNHVVFNRAT DPRKRASDLY DENEASGYHE EDTTLYRTYF VVNEPYDNEY
RDRESVQFQN LQKLLDDDLR NFFHSNYEGN DDEEQEIRST LERVEPTNDN FKIRVQLRIE
LPTSVNDFGS KLQQQLNVYN RIENLSAATD GVFSFTESSD IEEEAIDVTL PQEEVEGSGS
DDSSCRGDAT FTCPRSGKTI CDEMRCDREI QCPDGEDEEY CNYPNVCTED QFKCDDKCLE
LKKRCDGSID CLDQTDEAGC INAPEPEPEP EPEPEPEPES EPEAEPEPEP EPEPESEPEQ
EPEPQVPEAN ECQANEFRCN NGDCIDARKR CNNVSDCSEG EDENEECPAA CSGMEYQCRD
GTRCISVSQQ CDGHSDCSDG DDEEHCDGSG YDSEECRFDE FHCGTGECIP MRQVCDNIYD
CNDYSDEVNC VEGEEEDRVG IPIGHQPWRP ASKHDDWLHE MDTSEYQVYQ PSNVYEKANS
QNPCASNQFR CTTSNVCIPL HLRCDGFYHC NDMSDEKSCE QYQRHTTTRR PLTLATPTSR
ITTQGPGLLE RRNTTTATEA SRWPWATKTT TIATTTSNPI TTVGVANSPP QTCLENIEFA
CHNRDCISIE SVCDGIPDCG RNEDEDDALC KCSGDKYKCQ RGGGCIPKSQ VCDGKPQCHD
RSDESACHLH GRLNKTRLGV KCLESQYQCG DGSCISGYKR CNGIHDCADA SDEYNCIYDY
EDTYDTDPNN NPLNECDILE FECDYSQCLP LEKKCDGYAD CEDMSDELEC QSYTETNNHY
PTQNVNVIRP KLGPNPIPKS CRPHEWQCAN LECIDSSLQC NEIKDCSDGS DEELSVCFGT
ATTRLKPSDC SPEQFYCDES CYNRSVRCNG HVDCSDGSDE VGCSLPCPQH QCPSGRCYTE
SERCDRHRHC EDGSDEANCC YANQFRCNNG DCVSGSAPCN GYSECSDHSD ELNCGGTQEC
LPNQFRCNSG QCVSSSVRCN GRTDCQDSSD EQNCAADSND RRPNQLNLKT YPDSQIIKES
REVIFRCRDE GPARAKVKWS RPGGRPLPPG FTDRNGRLEI PNIRVEDAGT YVCEAVGYAS
YIPGQQVTVN LNVERYNDVG SRPESACTEY QATCMNGECI DKSSICDGNP DCSDASDEQS
CSLGLKCQPN QFMCSNSKCV DRTWRCDGEN DCGDNSDETS CDPEPSGAPC RYNEFQCRSG
HCIPKSFQCD NVPDCTDGTD EVGCMAPLPI RPPPQSVSLL EYEVLELTCV ATGTPTPTIV
WRLNWGHVPD KCESKSYGGT GTLRCPDMRP QDSGAYSCEI INTRGTHFVN PDTIVTVRPV
RTDVCEAGFF NMLARKAEEC VQCFCFGVAK ACDSANLFTY AIHPPILSHR VVSVELSPLR
QIVINEAAPG QDLLTLLHGV QFRATNVHFS GRETPYLALP ADYMGNQLKS YGGNLRYEVN
YRGSGRPVNG PDVIITGNRF TLTYRVRTQP GQNNRVSIPF VPGGWQKPDG RKASREEIMM
ILANVDNILI RLGYLDSTAR EVDLINIALD SAGTADKGLG SASLVEKCQC PPGYVGDSCE
SCASGYVRQP GGPWLGHCVP FIPDSCPSGT YGDPRRGVPC KECPCPLTGS NNFASGCQQS
PDGDVVCRCN EGYTGRRCEQ CAAGYQGNPL AAGGICRRIP DTSCNVDGTY SVHSNGTCQC
KDSVIGEQCD TCKSKSFHLN SFTYTGCIEC FCSGVGLDCD SSTWYRDQVT STFGRSRVDH
GFVLVTNYMQ PTPDTVPVSM AAEPNALSFI GSADQSGNTL YWSLPAAFLG NKLSSYGGKL
TYTLSYSPLP NGIMSRNSAP DVVIKSGEDL RLIHYRKSQV VPSVANTYSV EIKESAWQRG
DEVVANREHV LMALSDITAI YIKATYTTST KEASLRQVTL DVATPTNLGT PRAVEVEQCR
CPEGYLGLSC EQCAPGYARD PEGGIYLGLC RPCECNGHSK YCNSDTGDCE ECSDNTEGPS
CERCAAGYVG DATRGTIYDC QPDEGYPIPS PPAPGNQTLE CTAYCQIEGI YDCRGNECLC
KRNVIGDQCD QCRPGTYGLS AQNQDGCKEC YCSGLASQCR SAALYRQLIP VDFILNAPLI
TDESGAVQDT ENLIPDISRN MYTYTHTSYL PKYWSLRGSV LGNQLFSYGG RLSYSLIVES
YGNYERGHDI VLIGNGLKLI WSRPDGNENQ EEYNVRLHED EQWTRQDRES ARPASRSDFM
TVLSDLQHIL IRATPRVPTQ STSIGNVILE SAVTTRTPGA THASDIELCQ CPSGYVGTSC
ESCAPLHYRD ASGSCSLCPC DVSNTESCDL VSGGYVECRC KARWKGDRCR EIDTNDPTDI
GTEDPVLTQI IVSIQKPEIT IVPVGGSMTL SCSGRMRWSN SPVIVNWYKE NSRLPENVEV
QGGNLYLYDL QVSDSGVYIC QAVNNETASV FKDTVSITIT KKDQLSPAEI VNLPSHVTFE
EYVNNEIICE VLGNPAPRVT WARVDGHADA QSTRTYDNRL IFDSPRKSDE GRYRCQAEND
QNRDEKYVIV YVQSNPPQPP PQQDRLYITP EEINGLAGES FQLNCQFTSV ASLRYDWSHN
GRSLSSSPAR NVEIRGNTLE VRDASESDSG VYTCVAYDVR TRRNFTESAR VNIDRREEQP
FGNKPIIESL EQNILIIQGE DYSITCEASG SPYPSIKWAK VHDFMPENVH ISGNVLTIYG
ARFENRGVYS CVAENDHGSD LSSTSIDIEP RERPSVKIVS APLQTFSVGA PASLYCTVEG
IPDPTVEWVR VDGQPLSPRH KIQSPGYMVI DDIQLEDSGD YECRAKNIVG EATGVATITV
QEPTLVQIIP DNRDLRLTEG DELSLTCVGS GVPNPEVEWV NEMALKRDLY SPPSNTAILK
IYRVTKADAG IYTCHGKNEA GSDEAHVRVE VQERRGDIGG VDDDSDRDPI NYNPPQQQNP
GIHQPGSNQL LATDIGDNVT LTCDMFQPLN TRWERVDGAP LPRNAYTIKN RLEIVRVEQQ
NLGQYRCNGI GRDGNVKTYF VKELVLMPLP RIRFYPNIPL TVEAGQNLDV HCQVENVRPE
DVHWSTDNNR PLPSSVRIVG SVLRFVSITQ AAAGEYRCSA FNQYGNRSQI ARVAVKKPAD
FHQVPQSQLQ RHREGENIQL QCTVTDQYGV RAQDNVEFNW FRDDRRPLPN NARTDSQILV
LTNLRPEDAG RYICNSYDVD RGQQLPEVSI DLQVLTATPP PNSPIYLPPQ LPAKSRDYSL
KLDDQSSNLR AGESTDVECY SSDDTYTDVV WERSDGAPLS NNVRQVGNRL VISNVSPSDA
GNYVCKCKTD EGDLYTTSYK LEVEDQPHEL KSSKIVYAKV GANADLQCGA DESRQPTYRW
SRQYGQLQAG RSLMNEKLSL DSVQANDAGT YICTAQYADG ETADFPNILV VTGAIPQFRQ
EPRSYMSFPT LPNSSFKFNF ELTFRPENGD GLLLFNGQTR GSGDYIALSL KDRYAEFRFD
FGGKPMLVRA EEPLALNEWH TVRVSRFKRD GYIQVDEQHP VAFPTLQQIP QLDLIEDLYI
GGVPNWELLP ADAVSQQVGF VGCISRLTLQ GRTVELIREA KYKEGITDCR PCAQGPCQNK
GVCLESQTEQ AYTCICQPGW TGRDCAIEGT QCTPGVCGAG RCENTENDME CLCPLNRSGD
RCQYNEILNE HSLNFKGNSF AAYGTPKVTK VNITLSVRPA SLEDSVILYT AESTLPSGDY
LALVLRGGHA ELLINTAARL DPVVVRSAEP LPLNRWTRIE IRRRLGEGIL RVGDGPERKA
KAPGSDRILS LKTHLYVGGY DRSTVKVNRD VNITKGFDGC ISRLYNFQKP VNLLADIKDA
ANIQSCGETN MIGGDEDSDN EPPVPPPTPD VHENELQPYA MAPCASDPCE NGGSCSEQED
VAVCSCPFGF SGKHCQEHLQ LGFNASFRGD GYVELNRSHF QPALEQSYTS MGIVFTTNKP
NGLLFWWGQE AGEEYTGQDF IAAAVVDGYV EYSMRLDGEE AVIRNSDIRV DNGERHIVIA
KRDENTAILE VDRMLHSGET RPTSKKSMKL PGNVFVGGAP DLEVFTGFRY KHNLNGCIVV
VEGETVGQIN LSSAAVNGVN ANVCPANDDP LGGTEPPVV
//
