ID M9PC84_DROME Unreviewed; 12308 AA.
AC M9PC84;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Muscle-specific protein 300 kDa, isoform L {ECO:0000313|EMBL:AGB92626.1};
GN Name=Msp300 {ECO:0000313|EMBL:AGB92626.1,
GN ECO:0000313|FlyBase:FBgn0261836};
GN Synonyms=Bbbf1 {ECO:0000313|EMBL:AGB92626.1}, BBF-1
GN {ECO:0000313|EMBL:AGB92626.1}, BcDNA:AT10293
GN {ECO:0000313|EMBL:AGB92626.1}, BcDNA:GH02446
GN {ECO:0000313|EMBL:AGB92626.1}, BcDNA:GH18470
GN {ECO:0000313|EMBL:AGB92626.1}, BcDNA:LP10936
GN {ECO:0000313|EMBL:AGB92626.1}, CG14035 {ECO:0000313|EMBL:AGB92626.1},
GN CG18251 {ECO:0000313|EMBL:AGB92626.1}, CG18252
GN {ECO:0000313|EMBL:AGB92626.1}, CG31649 {ECO:0000313|EMBL:AGB92626.1},
GN CG31916 {ECO:0000313|EMBL:AGB92626.1}, CG33549
GN {ECO:0000313|EMBL:AGB92626.1}, CG33715 {ECO:0000313|EMBL:AGB92626.1},
GN Dmel\CG42768 {ECO:0000313|EMBL:AGB92626.1}, dNesp1
GN {ECO:0000313|EMBL:AGB92626.1}, jf22 {ECO:0000313|EMBL:AGB92626.1},
GN l(2)25Ch {ECO:0000313|EMBL:AGB92626.1}, l(2)jf22
GN {ECO:0000313|EMBL:AGB92626.1}, MSP-300 {ECO:0000313|EMBL:AGB92626.1},
GN Msp-300 {ECO:0000313|EMBL:AGB92626.1}, msp-300
GN {ECO:0000313|EMBL:AGB92626.1}, MSP300 {ECO:0000313|EMBL:AGB92626.1},
GN msp300 {ECO:0000313|EMBL:AGB92626.1}, Spec25CD
GN {ECO:0000313|EMBL:AGB92626.1};
GN ORFNames=CG42768 {ECO:0000313|EMBL:AGB92626.1,
GN ECO:0000313|FlyBase:FBgn0261836}, Dmel_CG42768
GN {ECO:0000313|EMBL:AGB92626.1};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AGB92626.1, ECO:0000313|Proteomes:UP000000803};
RN [1] {ECO:0000313|EMBL:AGB92626.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A.,
RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E.,
RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C.,
RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A.,
RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C.,
RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G.,
RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.,
RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537568;
RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster
RT euchromatic genome sequence.";
RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN [3] {ECO:0000313|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4] {ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537573;
RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M.,
RA Celniker S.E.;
RT "The transposable elements of the Drosophila melanogaster euchromatin: a
RT genomics perspective.";
RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
RN [5] {ECO:0000313|EMBL:AGB92626.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537574;
RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA Karpen G.H.;
RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.";
RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN [6] {ECO:0000313|EMBL:AGB92626.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA Ashburner M., Anxolabehere D.;
RT "Combined evidence annotation of transposable elements in genome
RT sequences.";
RL PLoS Comput. Biol. 1:166-175(2005).
RN [7] {ECO:0000313|EMBL:AGB92626.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569856; DOI=10.1126/science.1139815;
RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin.";
RL Science 316:1586-1591(2007).
RN [8] {ECO:0000313|EMBL:AGB92626.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569867; DOI=10.1126/science.1139816;
RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA Dimitri P., Karpen G.H., Celniker S.E.;
RT "Sequence finishing and mapping of Drosophila melanogaster
RT heterochromatin.";
RL Science 316:1625-1628(2007).
CC -!- SIMILARITY: Belongs to the nesprin family.
CC {ECO:0000256|ARBA:ARBA00008619}.
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DR EMBL; AE014134; AGB92626.1; -; Genomic_DNA.
DR RefSeq; NP_001260090.1; NM_001273161.1.
DR SMR; M9PC84; -.
DR DNASU; 3771968; -.
DR EnsemblMetazoa; FBtr0332405; FBpp0304678; FBgn0261836.
DR GeneID; 3771968; -.
DR AGR; FB:FBgn0261836; -.
DR CTD; 3771968; -.
DR FlyBase; FBgn0261836; Msp300.
DR VEuPathDB; VectorBase:FBgn0261836; -.
DR HOGENOM; CLU_000007_0_0_1; -.
DR OrthoDB; 5478539at2759; -.
DR BioGRID-ORCS; 3771968; 0 hits in 1 CRISPR screen.
DR ChiTaRS; Msp300; fly.
DR GenomeRNAi; 3771968; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0261836; Expressed in crop (Drosophila) and 33 other cell types or tissues.
DR ExpressionAtlas; M9PC84; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IDA:FlyBase.
DR GO; GO:0005635; C:nuclear envelope; IDA:FlyBase.
DR GO; GO:0005640; C:nuclear outer membrane; IDA:FlyBase.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:FlyBase.
DR GO; GO:0030018; C:Z disc; IDA:FlyBase.
DR GO; GO:0003779; F:actin binding; IDA:FlyBase.
DR GO; GO:0019901; F:protein kinase binding; IPI:FlyBase.
DR GO; GO:0007015; P:actin filament organization; IMP:FlyBase.
DR GO; GO:0016477; P:cell migration; IMP:FlyBase.
DR GO; GO:0051643; P:endoplasmic reticulum localization; IMP:FlyBase.
DR GO; GO:0008335; P:female germline ring canal stabilization; IMP:FlyBase.
DR GO; GO:0060361; P:flight; IMP:FlyBase.
DR GO; GO:0007523; P:larval visceral muscle development; IMP:FlyBase.
DR GO; GO:0040011; P:locomotion; IMP:FlyBase.
DR GO; GO:0007498; P:mesoderm development; NAS:FlyBase.
DR GO; GO:0034453; P:microtubule anchoring; IGI:FlyBase.
DR GO; GO:0051646; P:mitochondrion localization; IMP:FlyBase.
DR GO; GO:0007097; P:nuclear migration; IMP:FlyBase.
DR GO; GO:0051647; P:nucleus localization; IGI:FlyBase.
DR GO; GO:0006997; P:nucleus organization; IGI:FlyBase.
DR GO; GO:0007300; P:ovarian nurse cell to oocyte transport; IMP:FlyBase.
DR CDD; cd21241; CH_SYNE1_rpt1; 1.
DR CDD; cd21243; CH_SYNE1_rpt2; 1.
DR CDD; cd00176; SPEC; 12.
DR Gene3D; 1.20.58.60; -; 33.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR047290; CH_SYNE1_rpt1.
DR InterPro; IPR047291; CH_SYNE1_rpt2.
DR InterPro; IPR012315; KASH.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR47535:SF1; MUSCLE-SPECIFIC PROTEIN 300 KDA; 1.
DR PANTHER; PTHR47535; MUSCLE-SPECIFIC PROTEIN 300 KDA, ISOFORM G; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF10541; KASH; 1.
DR Pfam; PF00435; Spectrin; 7.
DR SMART; SM00033; CH; 2.
DR SMART; SM01249; KASH; 1.
DR SMART; SM00150; SPEC; 52.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 45.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS51049; KASH; 1.
PE 1: Evidence at protein level;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00385}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Proteomics identification {ECO:0007829|PeptideAtlas:M9PC84};
KW Reference proteome {ECO:0000313|Proteomes:UP000000803};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00385}; Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT TOPO_DOM 1..12258
FT /note="Cytoplasmic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00385"
FT TOPO_DOM 12280..12308
FT /note="Perinuclear space"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00385"
FT DOMAIN 630..737
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 777..882
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 12250..12308
FT /note="KASH"
FT /evidence="ECO:0000259|PROSITE:PS51049"
FT REGION 1..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 121..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 295..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 387..488
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 504..526
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2699..2724
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6631..6657
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 8546..8579
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 8929..8986
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 9094..9121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 9324..9422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 9465..9703
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 9732..9760
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 12216..12235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2280..2343
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2540..2567
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2894..2962
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3563..3590
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3931..3958
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 4107..4167
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 5651..5678
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 6146..6176
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 6356..6397
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 6454..6484
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 6567..6597
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 6966..7040
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 7419..7457
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 7643..7670
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 7722..7768
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 7799..7935
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 8297..8324
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 8448..8482
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 10035..10062
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 10135..10169
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 10193..10220
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 10254..10281
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 10979..11009
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 11183..11210
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 11244..11271
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 11618..11648
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 11739..11769
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 11854..11881
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 12131..12176
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 35..58
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 302..323
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 387..404
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 414..452
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 460..488
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2708..2724
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8560..8575
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8930..8978
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9096..9110
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9330..9344
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9403..9417
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9490..9584
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9617..9647
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9675..9703
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12216..12231
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 12308 AA; 1401150 MW; 9E10DE34A0B635E5 CRC64;
MADSGGPGSK HMDPTTIDAG GGGAGAAGGD DVPPVPAVRR RRAHEQKSSR EQVLEEEKSQ
QLETSTVTRT YMKTITTSLT TSSSSNVEEF ILGEHAAGAA AAPSPNQQRL RQKVAQYEKV
WSDGSSPVKR PAEQSSDELR LTDDQDEYDA ENPFEIDVHE IERRLRQERQ RGLAEAEAAK
LAFQQVQLRH TTPPRRVEVT SDQVASPFNV TLRTTSRMSP GAEHGNVEEH LAPFNVTLRT
TRRTKKKEFK ELENFLEGER TVREVPSADG VRTIITSSMT SDGGYAEEKI YRHGEGYVSP
RDSPSWSRSS YSSERSSVTP PRSVDLTAGG RRILIKLEQE SELTEENQTR DETDLSFGRQ
EVAMATGNID ITVGGSNPRR RLYQQTTVQV GGGNRTSPQD STPQRPRDLD LAGTTKTMLT
STPIGTKEQP QTGPKTLVSP AATCQLRGSS TEEPRKIVSH KTITSTTTKS TSSSTSATSS
SSTSRKLIET SPVVVGKIAQ IRTGKSNASD NDIDIDNDSD TEGRPASSIV IVSTPTRPTT
PATASVSASA VTPSASISAT AAHALSGIGT FSKSLRQDYQ TLATQSGRSN ESPSDQEYQE
FQSTMASINY ARSNSQYDSH IKEKREEQER VQKKTFTNWI NSYLLKRVPP LRIDDLINDL
RDGTKLIALL EVLSGERLPV EKGRVLRRPH FLSNANTALQ FLASKRIKLV NINPADLVDG
RPPVVLGLIW TIILYFQIEE NSRNLEYLGH GIGGSVSSLD SVGNQKHGDL KAEKWKQGAR
KTLLNWVTNA LPKDSGVEVK DFGASWRDGV AFLALIDAIK ANLVNLAELK KTSNRQRLET
AFDVAESKLG IAKLLDAEDV DVPKPDEKSI MTYVAQFLHK YPEPKGASRD QSHVQQEADE
LRRFLVEKTT EYEPMVMMSS FPRDFGEYLL ARSEVDAHLA AYNRLKQLIE SQSGFLQVSR
QSWEEINELW QRLQYQMMYW LWLLDSELPG DFGTVGKWLA EAEKLLMDND IPNAMNEETA
AVISRKLEEH KLFFADLPRI LAMFDNAKRS PVAQQIPLEQ LRNMERRLQE VGPKAAERRI
RLKFLEHKCC LIAFLNLVEN KMRGWTGKYG HEEKVAQQLE QYKNFVSRNK IFQEFQKAFV
DMQQVVEEYK RDGNVPRKEI NDIDRFMYET EERWKRVSME LKCCQNSLEE VVNCWRSWNQ
LAPTCEEWLQ LAEQKVNQSE DERLDFFQDI PVWKDKFDAL ASSANYLIAS CEEPIAQQLR
QRHGALSERF ERLFANTKQY MHAGDIIRSR QEYKSGIEQL SRWLRGAESV LDQRQVLGNS
EQVKEYGQQL QQLASEIDDN EELFKTISRN FQSLIQDLSR DEVDKMMKLL KQEKESLVRI
RAQLPAKLHL FHQLQIQQES LEAGQKEIHQ WLSEAEQLLG THNLSGGRDA INEQLHKHKT
YFSRTVYYRS MLESKNKVFQ NLLKAVSSDD KIDTAPASQQ MQQLNERFNY VIQNAQQWEQ
RLDSAAGGWS NFKDNERVVS EWLTQAESML VEKHIESKTT IETQKYFFEQ VNDRWMNDLV
QSAQQLLTTL PAQEQPAVVH SVEQLQSRWK NVLSQAPLHL LKLEFRLDEN AFYQSLKDVE
KELQLEQQAL NRNEDVDSIL QRNQQFLLQQ DVVPRLERCL QNMQRLAQAH RQQQPGDISL
DQAYDNAKSQ WQLLSNKLGD MRQTLQQIPA QWQGYHLKFN DMVDWMNGVD QSLKNIVNEV
NTMEEFEKEK VVFQKICQDA DNKREDMKWL VKTLDSLLSY ATEDEANLEQ KKLEDLIARY
KNLIPTIEIT MVKTEVFSKC YTYRREVHEV VCLLSKVKDQ TANIPAPDSL DRVNRLIEEQ
QYAINQLDHQ RPHIMSMLQR GRDLIKDVHA PAFVNAEVKN LETGWNQAYT ETSDKLQALK
GTQAVWSEFV DQKNDIFSML QTAETELRSL TPLQTDPKNV SQDLKSKRDL NVQLQQASHQ
LLPKLHALKS ELAPLAAPDK RPILEKEVTE VEKMFFNTME HVKDRVGYLE DYSAKWNNYK
TRLAELQEWA NKVAPKNIEA LQSEDLTPEE RVVKVQAFKR ILGDRMKQLD LLAADASELA
PKEGNIAEAK RLKGEITKLQ EVLSAINRNV DHQAQAVQED LVNWQQFQAG LQQIKPAVEQ
SEVKVNNVVS KPISLEEAVA MQQNAQQFET QCQEQLDKLH GISNISHKML CKTNAPDELD
AMHSRWTAVH ENAKQASAKL EKLVANWKSF DADAAKLEDW VGQGEQQMSR RPAVLNTPHI
DKLEKELVKL KSFNNEISQQ QAKLVTLGQN ADQISLHLAP EGAAALKDRV NQMKGKLQKL
SEATRGHINE VSDAIISRQD FNAKLVNFSN WMEQLRNQVT QVEEINPERV ETSLHVIHAL
LQEHADKKPS FNAIYDEVKQ LALGATPEES NALNDAYTAL VVNYQNLETN MLQKKAALEK
WTELLGWKND TESHLNYLKH QLDKPEGPAA EELSKVIDEI DNLGQGIGYW KGQAKEIDEN
PAIQLRDALS RRPLIATQIV NDVENKLENL KLRSQSQQQQ IQQMTVRKDK FHALEHNFGQ
ALQENRAKLD EILRQHPTLN NIDQIIADLV ALNDALKYQA DLKNRIHDEG SLLMREDIAS
MPAIQESLLI MDKNYDSLQN EIADRIQKYN LISQALREYA DSKDKFSKEL KKAEDLYNAI
PQQPRDETEL HQASEKTRKT MEQLRKSKLS LDELERRGNN VGKLFSAIGE PIPQEVPQEV
TAAKQHWQDL HDKTAKNAHV YETEAVIWSQ IEDAKKDLLP WLSETNQGLC DAADNSIEIE
FGPMRLSKYR TELPSYQALK DSIVEKTNDL VKINKGAEIP ALSALNKLLS EQFAEVNNNA
DRLSAITTSF NDQEQELRRR SKEAGERVSK LREQLIKCDD MSGDNNKIME RLQQCRALRG
ELDNSGNEID NIKQKVDELR NLYPTFSESI IPKELNNVQK RYENVDLYAK KIESSLLQFL
KKFHADKVGM LKRIIATQRE KVAWCQPESS SDKYNLDVKK SSLQEVSKSI DDCKARHAET
LKSLEMLKAV ESPQNLAELT SDAELLRKDM QALQDSFDQI KGILDENVDL WSQYEQSNEQ
ISNWLRDVEG RVKAETSSQV NLSEVPQKLQ ELSILQQDVL AHEPIINNLE QTSQQLIEKN
PEARIGQFVT HLVQRYQAVS KALTSYIDKI RGAQLSNANF AKAAKDFNEW FGDAKIEFQE
LARMGSPGSS SATAQQLQTV KNYIKTFDNG QILLNNAVDI GEALYPVVSP DNRERIRADL
RQMREKFDYL RDEANAFMQQ VEGVLIQKTS IEESYTQVSH YLNESKAKVP TTDELYPTLA
TKKAALQNYK TQLQEITLHK NALKQLHDKA VTLCDDESER KTDESIQEYN TLSKKISDRI
TTVGNHVVKH EAYDQVLEKA QDWLNTIKSE AIDILNETTF EKEGAEEKLL VVENLLQHKP
EGDSIFDTCH KLLETVLTQT HPSGHPALLK GFEEPKQSWE DFMTLCQDSL VKLKQLCSKW
DEFDTIIEEL DNWMKNVEAV VKNQNLKSTA EAKNAHLKQL QDISKDIERR GAAINELMDQ
GREIEGETDL NLKLSRLNTR YQTLKNLCKE SIAKYVNYVK DHESFDKDFD SFKQNLQSSV
DELAKTNEIV GDQSVLQDQQ NKLREMSDKR ILDSTLFEGL IDRGEKLYGH TSPEGREIIR
QQLRALRTLW DNYTDDLNSA TQKIDQCLLQ FNEFSIAQDQ LTKWLKDVDK AMQSHTEPKT
TLQEKRAQLQ NHKLLHQEIT THNVLVDNVC DKAQILVDQI KDNSLNVYLT SIKQLFQSIV
QKSDEILHNL DDCVQKHNEL NNALSSAKTW ISNEKAKLLE CDDAYGEKAD IKRKIETLGQ
LAQNKPQAMK IISDIRDLFE KVKATTSEKG NEVLDKEIEE LETTMKSHFD DIEGIEGKQK
DVLAQWDKFE KALEELTKWC RSAEAVFREQ QLQSTLHEKV EQLEKYKIQR ELILQKEKEI
DAFGDAAHAL LNNCGADRLK TLTTQITNRY QLLQVLSKEV VNRWSNLVDD HQFYQDKYNE
VDLWLQPIES QMAKVLLDEP TQSSNILQVL LSEKEQAESL FAALNAAGEK ALPETSTQGR
EKIRKDLRDI RDRWDKLDEG IRNLEKRQEA QGVQLSSYQD ILNQTVNWLD QVEKLIHNEN
PASWTSAQEI RSKLYKYKAT NQDINSHKRI VEAVNEKAAA LLGSAAPANA DEISKAVAEV
NKRYDQVGQD CAKLVADLDG AFDVYQQFSE LQKAQQDYQK NLWDRLTGYS DYSGNKAALQ
ARLQKINEIQ DALPEGVAKL KSLEDHIEQQ ASNIPARSKE VMARDLANLH ADFEKFGASL
SDVKSGLENR LQQWNDYEIN LDRLITWLGE AENSLKNYNL KSSFEEKEEQ LNGFQSLAQN
LRQNEADFDK VKDDTSELVQ SSGETRIAVN VQQVSSRFQS IQATAKEILK KCEQAVQDHG
HFNDKYKQCA DWLANAQARY DDCCDLSTVA SRDDLLKKQV VIQELLAQQP TATQLLNSTV
ELGEKCYGST ATEGREAIRS QLDDLTFDQL FDNIAITARK IQDKIAKWSG FDEIADSLKS
WLDETENALP ADIELKTTLD EKRNKLQTYR DILNDINNHQ VELGNLQEIA ANLPEKTELV
DQIIKDISDR FGKLQKRAQN YVERYEGIVS AHQQYSKAVM DAQEFIDATL NTVHYWGDLD
LEQISLHTNL DRLKNLKASL ADEFPRVDQV RALGEKVIPG TVDVGQVNIK SQIDTTQQEW
ESLLTTISST IEAIEARLQH WSEYEQLRDQ CLAWIRDTDN NLHAIDLKED LPKKRAQLDA
LKALQGDVRA KELEVDNVTE KAQTLLKGPS SNRASGPELV TKYQQIFHKV KELNNRWQQY
VTSHEDFDNA ISDCSSWINE IKEKLDYCSD MSSMSPKELD KKLATIQDVI LLKDEGSARV
LKILEQAQHV LANTAPGGHE AINKELTDLQ DLWSGIALRI MDVKSNLDDS ITQWSGFLDQ
VQNVRKFNEW LDGQVKELSE HQTTMTEKRA QLDRVKSTEE KVRVEKIDVD ALKIQAKEMI
ASGQQSQAAF QAQKVLDTFD ELFAKTQKLL SHRQDQYRDH RLFKEAYDDL VSWIGRAREK
FPSLKQSSLS DKLAIENAVQ ATEALLNKQA QGELLVEHLV HTGEVVLAST SAQGQEIIRN
DIRALRDSFE GLFREINQQK ENLEVTMVQW RAYKEEYERL MEWLQQIDIL VKNHKLNLCP
NLPEKEKQVA DMKEVMSRLE KGKDDIDKFN ASAASLLKSH LDTYVNNQLR HLSSVYQVQV
NLAKDVLKKV ETNRDQHREY DANMKSAKDW IANAKATIQS AGEGAGSKEA LQRRLEQIQD
LIRNRELGQN LVHTAINNGE KIIRNTRSDG RDAINTEMKE LQTEWDRLVK KMSTAKVQLE
TNLLQWADYS SSYSQLQQWI TDREAKLQQA CEQKIVKSKR GQPGLSSGLS ERKANLRQTN
NIVQDIVSFE PMIQSVTSKA SVLQQGAPGT EISDKYENLT KQAKDLYEKQ KNTIESYQSL
IDAGNEFATW LRNAKERLSK CSEPTGDKQA LAEKTHQLKI LQGELPEGAQ KLKNALEQGE
IACRSAEPED CEIIEQEVAL LQEEFDAYRE ALNKAKDYLE VGIVKWSDYQ DQYTEALEWL
SKTEALVQSY NKLQDSLIQK KVVLEQFQGH LQTLFDWQKT LDDLNMKAQV LLETCSDTRI
SNAIMQLTTK YNALLTLAKE VMRRLEMHYQ EHQQHHSLYE ECQSWIEKTR EKLSECEQIP
GTLNEVQIKL NTVKNLRQGF ETGQNKLRYL LELKEKVIMN TEQNGAAKIQ EDTEALKQDF
DKLLVDLNDV RQKLANRLAQ LEEIFKLYKI LIEWLEDVEP SVKTSDEFLN DLSEKRAALE
KFRVIQRDIN GHNDIVEKIN QRLKEDNSLD LKDFQPGLTK FDDLQTQVNK IIESLENQVN
SHEKYKQAYN ELQDWLRRTR IEVEQCADCH GEKDQVESRL NRLGDIQSSS LEGKALLEAC
EELSQAVIAT SGSEGQDNVA QEIKHLTSEW ETLQTISRDA RSSLESCLAA WQTFLQKFNK
INLWIETMNK RVTKSQEGEN KTPEDLVNAK KLLEEVLAEK DNVEDLNDNC ELLMEQSACT
RIRDQTIETQ ANYTKLLTSA QGLVAKIEKN LSDHTEFLNY KKEMDAWIEK AQQVLDDCST
DGDAAIIAQK LDTVNSLASR LPEGQHLLAL VQDAYSKASN ITPEDKQEKL RELMTKVRED
WDALGLAVKQ KLSDLKQAQN RWNDFAANKD KLEKWLNETE TTLKVAPETK GELSEMKTLL
ERYKTLSNEL KLKGNELEQL QSEARDLGTE VDAVNRLQSR CDKLKNDCSA HITALEQEMF
DYNAYHQSLQ DVEKWLLQIS FQLMAHNSLF ISNREQTQEQ IKQHEALLVE IQKYQTNLDD
LNAKGQAQIK RYESSTPAIR PTVESQLKNI QDSYNSLLQT SVQIKNRLLE SLAKFQEYED
TLDSIMRNLE TYEPIIQTEL DAPATSLELA QNQLRCAQEM QNKLNNEKSR LAAAVQACEA
ATASISRPSS PLETAMQAIP ERELIVRAKL EDLLDQKPPP KTRSSTGGVS TDDDKDEADV
EIQVELSDVN EALLDPIAHE RVKNYRRIVR LNSAHVGKLN ELVAKVQSHL GGLTASVSEL
EQQQKQRAEL QDWVKKQQSS VSDWMMRPCK LRPEAAQQEL VSMNDLLNSI GDKRSQLMLE
MTGSLGDEDT DLDDNIDKLE SELMDAIAKK QAGQNVIDGY RQGMADVQNW FDTLIKRMDV
LDRGSGLNCA QKMAAINEIK NEYELQGHPK IQELKGKAAQ VAEVISNLDG QQVEEQMKSL
DRRFADLGKR IDRKSQLLDV TNKGVEGAKG EIDQLQNWVK QQIEELQAPK PLGYTPKDAE
ARQQKIKSLM KDAEAKQSLA DVLEKRVANM QQELEPVEYS QLESALRNLN TENRNLSGVL
KAELDRALEA SKARKSLEND LDKARQWLKT KISEVRKLPV YHPLTSAEIE KKIQENRKYD
DDAKQFNDSV LTDVQRQAAN IMKDCDDADK AALQQILDEI AADYQTLKDE SSKRGKSLDD
LLQGRKAFED SMKNMGDWLN EMETATEGEL RTTSLPVLEE QLAHYKKLLS DAENKGGLIN
DVSEQGKSIL PTLSNADKLK LNDDIKNMKD RYGRIKNTID DRVNALGDHI KKYKDAKSRL
AECSQFLGNI QQKLRELNRP IGSRIEDVQD LLGAYEGILK ELKDSKSKMG DMQMDDLPEL
QSILAQQDDM IKLIEDQLAH LRQLLLLREQ FIALINEIIA FIMKYTDVII DIENSPDSLE
DKINKYDDVI VKIQECEGVL ASANDKGQKI ASEGNAADKN SITEQLQSLK NQLQNLRKAV
ESQRQKHQLQ LESHKKMAAE LSEILDWLHS HEGAAKSRPL LDRDPESVER ELQKHQSLSQ
DIESYLNKFN KINDGVKTEI GMPSSLLEML SEGRSLVASL PHELEEREKY LKNNRDSRLE
YMQLVAKFND WVHEAELRLQ NSQHGIDYEH LVQDLDEHKI FFGNEAPIRN LVHKQIQEAA
DKIWSSLNNY EQSELSAELA QFQTKLTNTL ANAKTQQSEL EKEAERWREY QQSIDRVKAT
IERTKFVDEP VQNLAGLHFN IQKLSHAIGN VQSQNSDLTL VNQQAQSLIR QADARNRQLI
EQDNAGLNRS WQDLVRSLEQ RRDNLQQLAE HWDGFENSLH AWEKALGRLE DKFRNVDPTV
RSRRHLEDTK NAIQELREES NQLKSSHKEI EALSKSILTF LGEVHKPSAE AIQAKVDKLV
EQQAKLNDTL RDKEQQVSKD LEEIEQVFRR ISQLQDKLNA LHEQLQSVHV YDEHIAQTEQ
LLITLNSQVQ QAAEESKLLV AQTTAHYQAK QNQLPSDIAQ EFTALELLAE RVQVTMETKE
KDFKRAKTVR TEYVDGVDEV QRWLLQAEVQ VQERSLTPTQ MKELLQRINH EITAIYERFT
LVKTNGQLII ENCRNSEEKT LVQTTIDQLA ASLAQVRGWL DEKKQAVGDS LDAWTRFMNL
YQIVMSWASE KRNFIDQTIE LRTLPEARNK LNDYVTSVKS IKPIVKHLSE MDKELEHIGQ
VTTVGDLKDK LQEAEDAKIS VEAVLLERNS LLQEACEEWD QCERKIKDIR SWHEKTKQGL
DSSQQQKKPL RDQLGFCEKT LADINVQKTK LRLSIEKLEV HFRNGMGGDP RLSENVDDLV
RVLDGLGELV KAKSQSLEQT LAQIDVYQQQ MQSLRQRIIQ EEQQLRLVMA PTYLPHDRER
ALAEQQLIQS NLEVHERDAI ELKNQAKKLP TDPATERLLN DTVDRIDLLL RRTQQGITMI
ANAMHGQKKR QQEIDEYQQH LLELEQWIIE VSAELASFEP TSDSSTDEQV LKSQVERSQQ
LLRTLKDRQQ SMEDLVEQTR QLQSHPDVSP LADTLMEQLQ SIITILREQV TVATKRIFTI
EKRIVDLRKA KSEEAQRQRV LADSLIKPPT EAPASPEAHE SIESNENTID SSSMPEEEIK
PTGVYVETQT SLSLQQPPVQ VVTTTTVEAQ TSFKEPAVET AEVALQTQKE RSPTENIMVT
QTVHHGQETI QIDTTRNKDV PDEPEDVQIE ARYHQRPKGD VDRATELILK NVPQAFETTF
VEPDETTTEV IVGPDGTKHI VLKKVTRTRQ QVVQQQQISS IETISDSDGN IEVHSTGQIN
LENVHTTDTK ADPEEGSVHT VITQQTRGAV VDSTQPEGVI LQEFETEPTI ETYEEVIAPG
SQAQLIPMQP GDVQTQGTIR AVVQQVTRKV IRKTRKIIKR VVIIDGKEHI TEEVVEEPEE
VEITEEETAP HINVNIVRTV DGKVVSEEEF QRMMQEPGVL IEEVATDLQK PTAEPQQEVF
DIESTQVTTT TRTTTATTQE QEQPEQQTQP TTTETTKEAP VELPAPQVDV EQPVVVATTS
PVHVPTADVV EPKDSSPTST TAAVVDVEAV VEDINEIWPL EHHLKPTNID FSQHVEELAA
PAAVTAETEA SMPVEEIWPT SPETGNSLTL EQYEFEPQSP HEESTKSDLV KPQETEPQVV
AETKPEGITT GSITITKTTT TITSSTEVPE ETLVQNVPAD EQQPPANKIK TDIQSFLEAE
QTLAAALKEQ SSTPTGASVA EDVQTQPEEI VLEERTVEIS TIKTEENQQE PVIVEEVKSL
PVEPEPVEPE LEEVAIAIVE QTEEKPEEPV IEKQPASGPI DLRAATQLFI SGEAAASTAP
QKTFQISAPS LEDNGAGVLK VVLGKESTNE EDTAAPTTGK VSMTIIETAA APAADAKRRR
KKKKRRDTKH EEELEQEQET EPEPVAAVKE PEVSSDVPVS PEDSPRDTVR HESIVEISPD
SDLSSIEIDT KVKIVEDAVV SSPSESPRTP MVELVIPTEV VELALVEDEE QQTTPRIPSP
TEKSEVEQDI KSVQTSPQHQ PKLDETAVQT SLEVQPDNQE NESQTLIVEI TETEAQTTPR
SEEQSVAVEI STTEIQTDVS GQPAETVEIS SQTTVTTTIE KELQTTPKDS PRAPEAGSSD
VVESLVQDLV KDMTTDLPVR TSEQSTVTET TTTTETHVQT TTPEPREQTE VIKPETAHEE
TSTVELVQFA DGEMQTTPPG DQQPASLDDS SLTATSISVS EPYELEVKTT VAIPADSDTS
VAEPTVYEYT QTMQLPKQEK KSKKDKKKKQ KNVPEVEQQL PEDQQISVTV EIAPELLSES
GIVVSTNQQI EDVPHVTPVV DTPIESEEVE TPKAQRVQLQ ITKTTVYDEY PDLPVHITEQ
NKVLIASQQS KRSGAGPTSS AVTIEEVGSP TEELVVPITP GPDNLSGEPH NIWFSATTSV
DKTPIELSQA LIMSESLQHY PGQQKLTQEP ILISTKEAIG DRIKQLKQAS PQQATPLSNV
LHLATLSEQI KELPTEQRIL EVNEGLKDLD VAIKNGDKTV IQTTVITVIE KVSTWLETIE
YRVYLIRQNS NEGPSEEKLD NYNQLNDELS TIKQNVVQLE RQLSKAEPEP QLLQCVDSLK
EHVDAVEQVT QQNQVQDSND LDKWHNFEVL LYNVSSVLAD LQQSYDLLIN QEYPLSAKLA
QLDELEQQHE AAQQQLAHLC QNARAFQRDF PGKKMPQDVH NAFETSKNIA NNIQAERERV
LQLQSLAEEY EQTLKEFTKI TVLADKLVES PIVSSSLEQL NNEVQKQRKF FVNLSHCRAM
LESLEENIDS ETREKHSELH KELYNRATSL LDKASERSSK LVQAASRWTV LEKGMRDELQ
WLQVAQQRVP DLSAVTSADY DQYTTLYQSL SNDISHHYVK MTQLSGIANK LQLLVQAPNL
VEETNEALIV LLKLREEVAL YLHRLLVFKE IWVQYEQQTD KLEAFVREAE QELRNIQIPS
QPTHQPIEHM RQFWEIKARF ELHNNVRTDT GLSFEKSLQV IPLADEMLQR QFHAQLEDRW
QAVAQAIELI QHNIVECLSS EDVPADEKLK MVERELQEIY LTMTSMKGVI KNEEELCLYI
ERVQVLRTRV GFIGNELGRI GLQEPAIEPE KVGELFSLSH KISTQIAEEL EGASVLRDQL
QAIQEGISNQ RKHQAKISVI LDECEAAERQ GADVLEKAVA DCQAAGEELV ISWQEIMRIR
QMLHTLPMRL KMSVSPVKLE RDISQLQDDH AFLESKCTNI MAILRSRLAV WLRYERQLEL
VHGSVQETDF MMELIRVHGQ VDYERLRKAT ERLEGLAGDL HNREQLIDEL KGAAKPLIES
CDVQIVEQIE SAVQEAVVAW NDTSENLQQL RTRYQRAVEL WDKYRNASAA VKNSIDQQMD
AVKSLEQPLD ALQHAKVCQD NLTTQNDRIL ELRDIVAKIA ADVGLDASAL MQGELDALGQ
RLAECKDAIT TLANVAETQD KERKELDKEV TLAKAYFNNV QQDISREAPQ NPKESEEQLA
ALRAHLQTLA RTEEQLRQLK ERHQNSEVAP SVASSDDDGI LEVLALWQKI FQDTFQEYHR
LSTRLARSQN SSEALRLWRQ YLQHVQSFLS CAIPEDYSSL REQQQLCAIH QNLLISQQSV
LSETPLESEL SEQYKALTNL HNETLSRIMQ RNGELERRVS GWNAYRQQLA ALLDWLRQRE
AERNALQLRY IHLKRVPHLK HRLDAMIQQL DQGEQQSKAL QEQQQELARH CDDALATAMR
MEQASIGQRI SNLRAALKTW QGFLQRVTQL SESYEQRVNQ LQQEFGAAQK LLDANSESLP
TQPAAIEQLL GSLRAQRVQL GAQVSALESL TVTQEELKEC ISPHDMKTIR QRNWLLWQQH
ADLDYQLANL INSIEERLSL LSNYQIRYDR ISQWLQRLEQ RVEKDADVTA MTNPEQAAKQ
LEQQVNSELQ LRDKEREWLL STSRELLTLY SEPEVRSQVQ QQSDSLIDRW QRLKYLAKQK
ATKIGELKMT LLRLEERIAL IRAWLFEVES QLDKPLNFES YTPNVIEAKL KEHEQIQRSI
EHHSSNVGEV LNLVEMLLND ADSWRTQVNT SGLAASAQNL EQRWKNVCSQ SAERKARILT
IWNLLQQLIK LTAEHKNWLG KQESQIAGFE RDQKSHSKHK LEERQMELRA KLEELESQSV
NLRQLEQIYA KLAMSAGVEP ENIQKLTLPT KVMVSMWRQL TPRCHALLDA IDKDAKLMRE
FNNAQLEATN SLNAIQKALE QLPSAENQQT SKAEPKAVLQ RLESLEKKLQ DAQQHVQQAD
NLAQEAKTRT KQQPQLKQLL ELVSAYTTLW QTVQTRIVTL KTTWLTRAAQ AAASLPVSEA
ANAAVQVNTL SQRKLRQAQQ MQRETSITAK DAYIMELQTA ITECQNNLDE LQRTVVDKTR
KPGPQKIAKL LGNAQSSTEL VKHLSHLLLT ECKADDQAAE VDTVAELTLR FDTLQSQWKA
RQQHDQNASE VGRLTCPLCT QRNWQQIDND LWRLEQWLQF AESTQKAQSA PPSNIELLED
VTQDHREFLL DLESHKSIIS SLNVVGDHLA THTLDTEKAR QLRSRLEADN ERWNNVCINA
TKWQGLLQTA LMGNSEFHQT IGELVEWLQR TEQNIKASEP VDLTEERSVL ETKFKKFKDL
RAELERCEPR VVSLQDAADQ LLRSVEGSEQ QSQHTYERTL SRLTDLRLRL QSLRRLSGIY
IVKLGAVLGY EGDNLGVPLH MLSSELLDNT TLSTSSMQAA APNTENANNT DGGDAVDGDV
INTTVLARGA RFLGRVARAS LPIQALMLLL LGVATLVPHG EDYTCMFSNT FARSLEPMLS
YPHGPPPT
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