ID M9PFA3_DROME Unreviewed; 1757 AA.
AC M9PFA3;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 24-JAN-2024, entry version 72.
DE SubName: Full=Pericentrin-like protein, isoform H {ECO:0000313|EMBL:AGB94553.1};
GN Name=Plp {ECO:0000313|EMBL:AGB94553.1,
GN ECO:0000313|FlyBase:FBgn0086690};
GN Synonyms=AKAP450 {ECO:0000313|EMBL:AGB94553.1}, CG13459
GN {ECO:0000313|EMBL:AGB94553.1}, CG18648 {ECO:0000313|EMBL:AGB94553.1},
GN CG6735 {ECO:0000313|EMBL:AGB94553.1}, CP309
GN {ECO:0000313|EMBL:AGB94553.1}, Cp309 {ECO:0000313|EMBL:AGB94553.1},
GN cp309 {ECO:0000313|EMBL:AGB94553.1}, D-PLP
GN {ECO:0000313|EMBL:AGB94553.1}, D-Plp {ECO:0000313|EMBL:AGB94553.1},
GN d-plp {ECO:0000313|EMBL:AGB94553.1}, Dmel\CG33957
GN {ECO:0000313|EMBL:AGB94553.1}, DPLP {ECO:0000313|EMBL:AGB94553.1},
GN DPlp {ECO:0000313|EMBL:AGB94553.1}, Dplp
GN {ECO:0000313|EMBL:AGB94553.1}, dPLP {ECO:0000313|EMBL:AGB94553.1},
GN dplp {ECO:0000313|EMBL:AGB94553.1}, l(3)s2172
GN {ECO:0000313|EMBL:AGB94553.1}, PACT {ECO:0000313|EMBL:AGB94553.1},
GN Pact {ECO:0000313|EMBL:AGB94553.1}, PCNT
GN {ECO:0000313|EMBL:AGB94553.1}, PLP {ECO:0000313|EMBL:AGB94553.1}, plp
GN {ECO:0000313|EMBL:AGB94553.1}, pPlp {ECO:0000313|EMBL:AGB94553.1};
GN ORFNames=CG33957 {ECO:0000313|EMBL:AGB94553.1,
GN ECO:0000313|FlyBase:FBgn0086690}, Dmel_CG33957
GN {ECO:0000313|EMBL:AGB94553.1};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AGB94553.1, ECO:0000313|Proteomes:UP000000803};
RN [1] {ECO:0000313|EMBL:AGB94553.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A.,
RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E.,
RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C.,
RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A.,
RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C.,
RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G.,
RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.,
RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537568;
RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster
RT euchromatic genome sequence.";
RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN [3] {ECO:0000313|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4] {ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537573;
RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M.,
RA Celniker S.E.;
RT "The transposable elements of the Drosophila melanogaster euchromatin: a
RT genomics perspective.";
RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
RN [5] {ECO:0000313|EMBL:AGB94553.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537574;
RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA Karpen G.H.;
RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.";
RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN [6] {ECO:0000313|EMBL:AGB94553.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA Ashburner M., Anxolabehere D.;
RT "Combined evidence annotation of transposable elements in genome
RT sequences.";
RL PLoS Comput. Biol. 1:166-175(2005).
RN [7] {ECO:0000313|EMBL:AGB94553.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569856; DOI=10.1126/science.1139815;
RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin.";
RL Science 316:1586-1591(2007).
RN [8] {ECO:0000313|EMBL:AGB94553.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569867; DOI=10.1126/science.1139816;
RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA Dimitri P., Karpen G.H., Celniker S.E.;
RT "Sequence finishing and mapping of Drosophila melanogaster
RT heterochromatin.";
RL Science 316:1625-1628(2007).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000256|ARBA:ARBA00004300}.
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DR EMBL; AE014296; AGB94553.1; -; Genomic_DNA.
DR RefSeq; NP_001261860.1; NM_001274931.1.
DR SMR; M9PFA3; -.
DR EnsemblMetazoa; FBtr0333940; FBpp0306065; FBgn0086690.
DR GeneID; 3772382; -.
DR AGR; FB:FBgn0086690; -.
DR CTD; 3772382; -.
DR FlyBase; FBgn0086690; Plp.
DR VEuPathDB; VectorBase:FBgn0086690; -.
DR HOGENOM; CLU_001309_0_0_1; -.
DR OrthoDB; 3030508at2759; -.
DR BioGRID-ORCS; 3772382; 0 hits in 3 CRISPR screens.
DR ChiTaRS; Plp; fly.
DR GenomeRNAi; 3772382; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0086690; Expressed in embryonic/larval hemocyte (Drosophila) and 24 other cell types or tissues.
DR ExpressionAtlas; M9PFA3; baseline and differential.
DR GO; GO:0005814; C:centriole; IDA:FlyBase.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0060090; F:molecular adaptor activity; IEA:InterPro.
DR GO; GO:0007098; P:centrosome cycle; IMP:FlyBase.
DR GO; GO:0060285; P:cilium-dependent cell motility; IMP:FlyBase.
DR GO; GO:0007020; P:microtubule nucleation; IDA:FlyBase.
DR GO; GO:0007605; P:sensory perception of sound; IMP:FlyBase.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR InterPro; IPR028745; AKAP9/Pericentrin.
DR InterPro; IPR019528; PACT_domain.
DR PANTHER; PTHR44981; PERICENTRIN-LIKE PROTEIN, ISOFORM F; 1.
DR PANTHER; PTHR44981:SF2; PERICENTRIN-LIKE PROTEIN, ISOFORM F; 1.
DR Pfam; PF10495; PACT_coil_coil; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Proteomics identification {ECO:0007829|PeptideAtlas:M9PFA3};
KW Reference proteome {ECO:0000313|Proteomes:UP000000803}.
FT DOMAIN 1566..1638
FT /note="Pericentrin/AKAP-450 centrosomal targeting"
FT /evidence="ECO:0000259|Pfam:PF10495"
FT REGION 217..241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 589..624
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 825..862
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1178..1206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1290..1325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1340..1360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 252..300
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 375..458
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 990..1137
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 589..608
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 830..846
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1290..1309
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1757 AA; 200372 MW; 7BDCAC2445E43FB1 CRC64;
MSRLKLEFEK QLNRKNKRHL TFDAARDLEQ VICERDGLRE LSKSFRSVLC RLAKCVAHCE
EDLNATLSEE VQRLLFHSRS QDGGDDLEAT ISSSLNNTKH MLRVPDVHSL LEVVEDPSLV
QFIDSKSNEE PSEDFDLNDC LERLKSEASY LLHLSEDLHK QRTHDESSEH LDEPEKQEHE
LCCEAEDGLK TTGAVNQQVL SKFLRTNSLN DQQMGVANQR KNSNPEAGKT HSSLPPDLQE
HAGNASELSF QLVQLKNRLI KSEADRQNLQ QQLSRTIDRN AELGQELQAL RDQLSQLNSL
NHTDYNEGYG LGTMKSLQEQ GLDQSSASFL ALQERARHLL SSSPVKEQPS RDHGNSTVIL
LQMIEDFCRE GDKVVEFSKK DREDLQSQID TADKQLKDTR RFLEDQAAER EQERDEFQRE
IERLKAQLRD KEKEHSSYAN ASEEYAQLES QFREVNQQLC ESNAKRDKFE VELKASIDKI
FVLREIISEL ETQVQTKALN EEVLAEKAQQ LEEYVSLQMR DNDILQQEVH SLKTDIGEGY
QSRIRVLEEK LKQSGPTAEQ GVVLSQVAEK LRDIETTLDQ KTKALESLHN SNATSNSASL
SVTEDVSIHG SKEPTAVGSP SHPSLTVEGV QRVTEKLDRH TRVEEAAIKR IRDLEMQVHQ
MRAGCVELQH ERDTLQGRME EQTQRISTLQ NRLEEQRQRA EQLHRTGTSD LNTRVHELQG
EVQNLYEQLA ARDKQMANMR QQLQRSKEEI TRLETEVEVR TQPDRSLVNK LQAEVQQKGA
EIVKLKDKIR TEMINRLAIP DLMETMLADK NDEIDHLRDQ LEAKEKELQA SQQEASQISS
PSGAAGKQEG SGGKLSARTL SDIGSITEFP EPDVERRAAM RSLTALQMSE GAGGFLHQTM
ETSKEAVANL THKRTDDLSG FIVPYPVNTF EHPHYFQALG VTAQSTDGLT PGLVPRQINF
SNLTEDSKLK TTSLLMHTPE LPRPTTPPEI HQLRVKLSDL QTEKQRQQSE LEKKLQDLQK
ELEQEKEKLS RQAQTLQSYE ESEAKYRLRI ENLESKVLET AAQAASDREN LRKELNCVSA
AHEQCENAAA ARKRELEKLN SEVKVKADQL HAALRRCADL ELQVLTLERD LERLKNSDNS
SKQYSVDEIA QQVEKELNYS AQLDSNILKA IESEEENNLD KKLQKGVQTE EETLPGTGNG
TDDENFTGER ELLNQLEALR AQLAVEREQC EAMSKELLGE KQHSQDIQEQ DVIIIEAMRK
RLETALDAED ELHKQLDQER ERCERLQTQL TSLQRAESRR NSSLLLKSPG DSPRKSPRAD
FESELGDRLR SEIKLLVAQN ERERERSADA QRSSERERQR YEKELQERVA YCERLKQEME
KLSRDKESAE TELEHFNERL TLQASEIESL EARLVTLQEA ETRRANTRTR QHQENVKLQA
EIHELKSKLL AAEAARDCLD QKVTQLRFDV SRSGQREAKL AEALAQANDR LAHSTDDNVP
AQFMQKMKEI NALLAENTQE NRQMAETVQF LVGERIALQK KCEELGGAGN TNVTELEERC
RQLIGRYLRV ESHRKALVYQ KRYLKLTLEG YQASEQLALQ NLRGGAEQPP QRNIKKKFKT
VALAIIAIQR IKYIGRIWHT GKRIVSKSVF TITQQRSPGL NLNVAPPQSP LPGPNSNLPT
NNNNLMGRLS YAPLSPPMVN FSTVQPIMLP SDFTLQAPTT SLQTTIANNN SENTLPSLAR
LDWPTMQKPK RAHARHH
//
