ID M9R7E4_9RHOB Unreviewed; 450 AA.
AC M9R7E4;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=OAN307_c25500 {ECO:0000313|EMBL:AGI68147.1};
OS Octadecabacter antarcticus 307.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Octadecabacter.
OX NCBI_TaxID=391626 {ECO:0000313|EMBL:AGI68147.1, ECO:0000313|Proteomes:UP000005307};
RN [1] {ECO:0000313|EMBL:AGI68147.1, ECO:0000313|Proteomes:UP000005307}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=307 {ECO:0000313|EMBL:AGI68147.1,
RC ECO:0000313|Proteomes:UP000005307};
RX PubMed=23671678;
RA Vollmers J., Voget S., Dietrich S., Gollnow K., Smits M., Meyer K.,
RA Brinkhoff T., Simon M., Daniel R.;
RT "Poles Apart: Arctic and Antarctic Octadecabacter strains Share High Genome
RT Plasticity and a New Type of Xanthorhodopsin.";
RL PLoS ONE 8:E63422-E63422(2013).
CC -!- FUNCTION: Poorly processive, error-prone DNA polymerase involved in
CC untargeted mutagenesis. Copies undamaged DNA at stalled replication
CC forks, which arise in vivo from mismatched or misaligned primer ends.
CC These misaligned primers can be extended by PolIV. Exhibits no 3'-5'
CC exonuclease (proofreading) activity. May be involved in translesional
CC synthesis, in conjunction with the beta clamp from PolIII.
CC {ECO:0000256|ARBA:ARBA00025589}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SUBUNIT: Monomer. {ECO:0000256|ARBA:ARBA00011245}.
CC -!- SIMILARITY: Belongs to the DNA polymerase type-Y family.
CC {ECO:0000256|ARBA:ARBA00010945}.
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DR EMBL; CP003740; AGI68147.1; -; Genomic_DNA.
DR RefSeq; WP_015500161.1; NC_020911.1.
DR AlphaFoldDB; M9R7E4; -.
DR STRING; 391626.OAN307_c25500; -.
DR KEGG; oat:OAN307_c25500; -.
DR eggNOG; COG0389; Bacteria.
DR HOGENOM; CLU_012348_1_1_5; -.
DR OrthoDB; 9808813at2; -.
DR Proteomes; UP000005307; Chromosome.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0009432; P:SOS response; IEA:UniProt.
DR CDD; cd00424; PolY; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.40.1170.60; -; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR017961; DNA_pol_Y-fam_little_finger.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR001126; UmuC.
DR PANTHER; PTHR11076:SF33; DNA POLYMERASE KAPPA; 1.
DR PANTHER; PTHR11076; DNA REPAIR POLYMERASE UMUC / TRANSFERASE FAMILY MEMBER; 1.
DR Pfam; PF00817; IMS; 1.
DR Pfam; PF11799; IMS_C; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50173; UMUC; 1.
PE 3: Inferred from homology;
FT DOMAIN 13..194
FT /note="UmuC"
FT /evidence="ECO:0000259|PROSITE:PS50173"
SQ SEQUENCE 450 AA; 49638 MW; D6A89C7F30BC9782 CRC64;
MQHSRGQARG IERLYLDFDS FFASAEQHLN PYLRGRPVGV VPLDSLHTSC IAVSREAKAL
GVKSRTTIIK AREIIPDMIF VVARHDVYVR LHKRILDVIE TCLPVTHVRS IDEVVCNLLR
VEAAEGEALA LRLKTAIALA FSDVLTCSIG MAPTELRAKI AAELNKPNGF KLLPAADMPD
ALAEVDLCDL PGISEGMQAR LKAAQVHNFT ALWALAPKQA RAIWGSVEGE RFWNGLHGYH
TERPPTKKSM FGHSRVLPKD WRNPEKVRVC ARLLIESAGR RLRRANMRAT KLTLSFRGGG
YRSAHESRRD DQNWGWEGNF LPARDDYAFL LALSDGLTWA EQHMAFQPRS VSVMIHGLIV
EGEFMTDLFA ASPDAASGMS EAASRAKWEK VSDLMDNMRA KFGPHALSLG PPGEVPGGYL
GAKIAFGRIP DEADFSGAPV ADSNTHFVTI
//
