ID M9SBW4_METAX Unreviewed; 245 AA.
AC M9SBW4;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=DNA polymerase sliding clamp {ECO:0000256|HAMAP-Rule:MF_00317};
DE AltName: Full=Proliferating cell nuclear antigen homolog {ECO:0000256|HAMAP-Rule:MF_00317};
DE Short=PCNA {ECO:0000256|HAMAP-Rule:MF_00317};
GN Name=pcn {ECO:0000256|HAMAP-Rule:MF_00317};
GN ORFNames=MMALV_01790 {ECO:0000313|EMBL:AGI84935.1};
OS Methanomethylophilus alvi (strain Mx1201).
OC Archaea; Candidatus Thermoplasmatota; Thermoplasmata;
OC Methanomassiliicoccales; Methanomethylophilaceae; Methanomethylophilus.
OX NCBI_TaxID=1236689 {ECO:0000313|EMBL:AGI84935.1, ECO:0000313|Proteomes:UP000012672};
RN [1] {ECO:0000313|EMBL:AGI84935.1, ECO:0000313|Proteomes:UP000012672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Mx1201 {ECO:0000313|EMBL:AGI84935.1,
RC ECO:0000313|Proteomes:UP000012672};
RX PubMed=23209209; DOI=10.1128/JB.01867-12;
RA Borrel G., Harris H.M., Tottey W., Mihajlovski A., Parisot N.,
RA Peyretaillade E., Peyret P., Gribaldo S., O'Toole P.W., Brugere J.F.;
RT "Genome sequence of 'Candidatus Methanomethylophilus alvus' Mx1201, a
RT methanogenic archaeon from the human gut belonging to a seventh order of
RT methanogens.";
RL J. Bacteriol. 194:6944-6945(2012).
CC -!- FUNCTION: Sliding clamp subunit that acts as a moving platform for DNA
CC processing. Responsible for tethering the catalytic subunit of DNA
CC polymerase and other proteins to DNA during high-speed replication.
CC {ECO:0000256|HAMAP-Rule:MF_00317}.
CC -!- SUBUNIT: Homotrimer. The subunits circularize to form a toroid; DNA
CC passes through its center. Replication factor C (RFC) is required to
CC load the toroid on the DNA. {ECO:0000256|HAMAP-Rule:MF_00317}.
CC -!- SIMILARITY: Belongs to the PCNA family. {ECO:0000256|HAMAP-
CC Rule:MF_00317}.
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DR EMBL; CP004049; AGI84935.1; -; Genomic_DNA.
DR RefSeq; WP_015504084.1; NC_020913.1.
DR AlphaFoldDB; M9SBW4; -.
DR STRING; 1236689.MMALV_01790; -.
DR GeneID; 41320977; -.
DR KEGG; max:MMALV_01790; -.
DR eggNOG; arCOG00488; Archaea.
DR HOGENOM; CLU_043978_1_1_2; -.
DR InParanoid; M9SBW4; -.
DR OrthoDB; 14749at2157; -.
DR Proteomes; UP000012672; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030337; F:DNA polymerase processivity factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR CDD; cd00577; PCNA; 1.
DR Gene3D; 3.70.10.10; -; 1.
DR HAMAP; MF_00317; DNApol_clamp_arch; 1.
DR InterPro; IPR046938; DNA_clamp_sf.
DR InterPro; IPR000730; Pr_cel_nuc_antig.
DR InterPro; IPR022659; Pr_cel_nuc_antig_CS.
DR InterPro; IPR022648; Pr_cel_nuc_antig_N.
DR PANTHER; PTHR11352; PROLIFERATING CELL NUCLEAR ANTIGEN; 1.
DR PANTHER; PTHR11352:SF0; PROLIFERATING CELL NUCLEAR ANTIGEN; 1.
DR Pfam; PF00705; PCNA_N; 1.
DR PRINTS; PR00339; PCNACYCLIN.
DR SUPFAM; SSF55979; DNA clamp; 2.
DR PROSITE; PS01251; PCNA_1; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|HAMAP-Rule:MF_00317};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00317}; Reference proteome {ECO:0000313|Proteomes:UP000012672}.
FT DOMAIN 1..103
FT /note="Proliferating cell nuclear antigen PCNA N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00705"
SQ SEQUENCE 245 AA; 26688 MW; 7E03A5AEC84B8879 CRC64;
MFKAEIKSDT LKGIVYIVST LVDEVKFTIH PDSLSLKAID PAHVAMLDIT VSKDAFENYS
ADETEIGLDL DKVKSVLKLA GPGDSIILEH DPDQGRLTFR IGNITRRMSL VDTSSMNDPK
VPQIELATDV KVKIDHLKKG ISAAESISDH ISLEADPEGF ELACEGDTDL ASLRLPASDL
EGLKSEGKVS SLYPLDYFSN IVKVIPAGTV VDIQLDNDYP VKILFALAEG KADVVYFLAP
RIESD
//
