GenomeNet

Database: UniProt
Entry: M9SFA7_METAX
LinkDB: M9SFA7_METAX
Original site: M9SFA7_METAX 
ID   M9SFA7_METAX            Unreviewed;       198 AA.
AC   M9SFA7;
DT   26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 1.
DT   13-NOV-2019, entry version 28.
DE   RecName: Full=Probable thymidylate kinase {ECO:0000256|HAMAP-Rule:MF_00165};
DE            EC=2.7.4.9 {ECO:0000256|HAMAP-Rule:MF_00165};
DE   AltName: Full=dTMP kinase {ECO:0000256|HAMAP-Rule:MF_00165};
GN   Name=tmk {ECO:0000256|HAMAP-Rule:MF_00165};
GN   ORFNames=MMALV_01370 {ECO:0000313|EMBL:AGI84893.1};
OS   Methanomethylophilus alvus (strain Mx1201).
OC   Archaea; Euryarchaeota; Diaforarchaea group; Thermoplasmata;
OC   Methanomassiliicoccales; Candidatus Methanomethylophilaceae;
OC   Candidatus Methanomethylophilus.
OX   NCBI_TaxID=1236689 {ECO:0000313|EMBL:AGI84893.1, ECO:0000313|Proteomes:UP000012672};
RN   [1] {ECO:0000313|EMBL:AGI84893.1, ECO:0000313|Proteomes:UP000012672}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Mx1201 {ECO:0000313|EMBL:AGI84893.1,
RC   ECO:0000313|Proteomes:UP000012672};
RX   PubMed=23209209; DOI=10.1128/JB.01867-12;
RA   Borrel G., Harris H.M., Tottey W., Mihajlovski A., Parisot N.,
RA   Peyretaillade E., Peyret P., Gribaldo S., O'Toole P.W., Brugere J.F.;
RT   "Genome sequence of 'Candidatus Methanomethylophilus alvus' Mx1201, a
RT   methanogenic archaeon from the human gut belonging to a seventh order
RT   of methanogens.";
RL   J. Bacteriol. 194:6944-6945(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + dTMP = ADP + dTDP; Xref=Rhea:RHEA:13517,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:58369, ChEBI:CHEBI:63528,
CC         ChEBI:CHEBI:456216; EC=2.7.4.9; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_00165};
CC   -!- SIMILARITY: Belongs to the thymidylate kinase family.
CC       {ECO:0000256|HAMAP-Rule:MF_00165}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; CP004049; AGI84893.1; -; Genomic_DNA.
DR   RefSeq; WP_015504042.1; NC_020913.1.
DR   STRING; 1236689.MMALV_01370; -.
DR   EnsemblBacteria; AGI84893; AGI84893; MMALV_01370.
DR   GeneID; 41320935; -.
DR   KEGG; max:MMALV_01370; -.
DR   KO; K00943; -.
DR   OMA; FLYTADH; -.
DR   OrthoDB; 114844at2157; -.
DR   BioCyc; CMET1236689:G1HAY-137-MONOMER; -.
DR   Proteomes; UP000012672; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004798; F:thymidylate kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006233; P:dTDP biosynthetic process; IEA:InterPro.
DR   GO; GO:0006235; P:dTTP biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00165; Thymidylate_kinase; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039430; Thymidylate_kin-like_dom.
DR   InterPro; IPR018095; Thymidylate_kin_CS.
DR   InterPro; IPR018094; Thymidylate_kinase.
DR   Pfam; PF02223; Thymidylate_kin; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00041; DTMP_kinase; 1.
DR   PROSITE; PS01331; THYMIDYLATE_KINASE; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00165};
KW   Complete proteome {ECO:0000313|Proteomes:UP000012672};
KW   Kinase {ECO:0000256|HAMAP-Rule:MF_00165, ECO:0000313|EMBL:AGI84893.1};
KW   Nucleotide biosynthesis {ECO:0000256|HAMAP-Rule:MF_00165};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00165};
KW   Reference proteome {ECO:0000313|Proteomes:UP000012672};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_00165,
KW   ECO:0000313|EMBL:AGI84893.1}.
FT   DOMAIN        8    183       Thymidylate_kin. {ECO:0000259|Pfam:
FT                                PF02223}.
FT   NP_BIND      10     17       ATP. {ECO:0000256|HAMAP-Rule:MF_00165}.
SQ   SEQUENCE   198 AA;  21812 MW;  4D49DF80F6C0C141 CRC64;
     MRGRFIVLEG VDGTGKTTLA KRLADLVGDA VVTSEPTSGR IGSALRSGEL GDIPPAAEAL
     LFAADRAIHT AEIEKVLESG RWVVCDRYMG STVAYQSASM GEDADIEWLI GMQKNAVIEP
     DATFLLDMDP EESLRRVDSR GEDKSRFEKL DFLRDVREGY LRLAERFGYC VIDASKDRDA
     VFADVLEALR EKGLYASE
//
DBGET integrated database retrieval system