ID M9SFH2_METAX Unreviewed; 1203 AA.
AC M9SFH2;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Chromosome partition protein Smc {ECO:0000256|HAMAP-Rule:MF_01894};
GN Name=smc {ECO:0000256|HAMAP-Rule:MF_01894};
GN ORFNames=MMALV_02170 {ECO:0000313|EMBL:AGI84973.1};
OS Methanomethylophilus alvi (strain Mx1201).
OC Archaea; Candidatus Thermoplasmatota; Thermoplasmata;
OC Methanomassiliicoccales; Methanomethylophilaceae; Methanomethylophilus.
OX NCBI_TaxID=1236689 {ECO:0000313|EMBL:AGI84973.1, ECO:0000313|Proteomes:UP000012672};
RN [1] {ECO:0000313|EMBL:AGI84973.1, ECO:0000313|Proteomes:UP000012672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Mx1201 {ECO:0000313|EMBL:AGI84973.1,
RC ECO:0000313|Proteomes:UP000012672};
RX PubMed=23209209; DOI=10.1128/JB.01867-12;
RA Borrel G., Harris H.M., Tottey W., Mihajlovski A., Parisot N.,
RA Peyretaillade E., Peyret P., Gribaldo S., O'Toole P.W., Brugere J.F.;
RT "Genome sequence of 'Candidatus Methanomethylophilus alvus' Mx1201, a
RT methanogenic archaeon from the human gut belonging to a seventh order of
RT methanogens.";
RL J. Bacteriol. 194:6944-6945(2012).
CC -!- FUNCTION: Required for chromosome condensation and partitioning.
CC {ECO:0000256|HAMAP-Rule:MF_01894}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_01894}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01894}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- DOMAIN: Contains large globular domains required for ATP hydrolysis at
CC each terminus and a third globular domain forming a flexible hinge near
CC the middle of the molecule. These domains are separated by coiled-coil
CC structures. {ECO:0000256|HAMAP-Rule:MF_01894}.
CC -!- SIMILARITY: Belongs to the SMC family. {ECO:0000256|HAMAP-
CC Rule:MF_01894}.
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DR EMBL; CP004049; AGI84973.1; -; Genomic_DNA.
DR RefSeq; WP_015504122.1; NC_020913.1.
DR AlphaFoldDB; M9SFH2; -.
DR STRING; 1236689.MMALV_02170; -.
DR GeneID; 41321016; -.
DR KEGG; max:MMALV_02170; -.
DR eggNOG; arCOG00371; Archaea.
DR HOGENOM; CLU_001042_2_2_2; -.
DR InParanoid; M9SFH2; -.
DR OrthoDB; 9143at2157; -.
DR Proteomes; UP000012672; Chromosome.
DR GO; GO:0005694; C:chromosome; IEA:InterPro.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030261; P:chromosome condensation; IEA:InterPro.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR GO; GO:0007062; P:sister chromatid cohesion; IEA:InterPro.
DR Gene3D; 1.10.287.1490; -; 1.
DR Gene3D; 1.20.1060.20; -; 1.
DR Gene3D; 3.30.70.1620; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR HAMAP; MF_01894; Smc_prok; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003395; RecF/RecN/SMC_N.
DR InterPro; IPR024704; SMC.
DR InterPro; IPR010935; SMC_hinge.
DR InterPro; IPR036277; SMC_hinge_sf.
DR InterPro; IPR011890; SMC_prok.
DR NCBIfam; TIGR02169; SMC_prok_A; 1.
DR NCBIfam; TIGR02168; SMC_prok_B; 1.
DR PANTHER; PTHR18937; STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER; 1.
DR Pfam; PF06470; SMC_hinge; 1.
DR Pfam; PF02463; SMC_N; 1.
DR PIRSF; PIRSF005719; SMC; 1.
DR SMART; SM00968; SMC_hinge; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF75553; Smc hinge domain; 1.
DR SUPFAM; SSF57997; Tropomyosin; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|HAMAP-Rule:MF_01894};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|HAMAP-
KW Rule:MF_01894};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_01894};
KW DNA-binding {ECO:0000256|HAMAP-Rule:MF_01894};
KW Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_01894};
KW Reference proteome {ECO:0000313|Proteomes:UP000012672}.
FT DOMAIN 531..647
FT /note="SMC hinge"
FT /evidence="ECO:0000259|SMART:SM00968"
FT REGION 368..388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 193..220
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
FT COILED 694..798
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
FT COILED 832..957
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
FT BINDING 32..39
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
SQ SEQUENCE 1203 AA; 132559 MW; 1DF51D29158770E2 CRC64;
MYLKQIELEN FKSFGGKVTV PLMEGYMAVT GPNGSGKSNI ADAILFVLGP RSSKAVRASR
ITDLIFDGGA AKSKAKFMKV SLVFDNSDRI MPWDDDTVIL TRYVKLSENG TDYTSYFFIN
DQKSSLSEFD TLLTKARISA DGYNIVQQGD VTHIVQMGNI ERRRILDGIS GIASFDADID
KAKGERAEAS SNLERIDIIR AEKERQISAL EKDREQAKVY LEAKKDLDIA NAQMVYRLRD
NEKATFDSLG ANIALIQKDI EGLRKDKAAL LGQRQENEAA VRAKEDEIAA KVGPDYLRIK
GDVEQAKIDV ATEKSKHDSA VEDAEDQREF REGFVQDVEE NRNQYATSAQ NLSDLQIRLE
GAQADLAAAE EEERRISEET SKHGGELTEL QKRLETLERD IDAAGHVQQD AQAKAAGAQA
VLDEARVAKA KAEEDLESAR FEVKDADWNL QEVKRQAGPQ NEIDELGKQI MALKKEEAAK
EKEEEELKDI AEKRTAEFNR LSTEKRVSES MNKGSEAMSR ILALKESGQM PGIHGTVAEL
ATVDPGYETA LSVAAGNKMG AIVVDNKDVA ARCIEYLKKN GLGRVTFLPL TELLPGKPRA
KAIIALKSTD GYATDFVTYK PEYANVFWYV FGDTLVVGTL DKAKEVMGGV RIVTKAGELI
EASGAMTGGT IDKRKVQQFG PSGQSALEAA GAEMRKAVEA LAVLRSDLRQ LRDAIRQTDD
LMRAAGTKGI DMKGKIVAAE AALEQARKGV KSAEEVLSKR TSDVTAAEKA LSDAAAALDA
ANSKLDSLRE ERTAARDRMA VIAPAGLQER IQKARDAVYC HTQTVTDLLQ QIGGLKAEMS
GLDKQKEALE EQISKIDSQI AEDEKAASEH AAKVEEFRVR LEAVKRIQDE MESKIEDLKA
ERDALIQNGY SLDNAVEKAQ NGIEAKDGYL QSQTAQMETS RINLEQYEEQ VKALTVEVPE
PIPSESSLKV AIRQCQAKID ALGHVNLRAI EDYDICKQEY DLMMGQVAIL NNRISDLDRL
TEDLSRKKKG LFMEAYDAVD SNFKAIYAQL SGGGQAFMAL DVPEDPFSGG LQINAKPRNG
KMLRLEALSG GEKSLTALAF IFAIQEYQPS PFYVLDEVDM FLDAVNAEMV ARRVKESSAR
TQFIQVSLRK VTLTLADHLI GVTRPPTGIS RVIMQPDIAE VSKYEEEALR RQREEGSSDN
IEG
//
