ID M9W9W9_9MOLU Unreviewed; 224 AA.
AC M9W9W9;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=adenosylhomocysteine nucleosidase {ECO:0000256|ARBA:ARBA00011974};
DE EC=3.2.2.9 {ECO:0000256|ARBA:ARBA00011974};
GN Name=mtnN {ECO:0000313|EMBL:AGJ90798.1};
GN ORFNames=MPUT9231_3840 {ECO:0000313|EMBL:AGJ90798.1};
OS Mycoplasma putrefaciens Mput9231.
OC Bacteria; Mycoplasmatota; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX NCBI_TaxID=1292033 {ECO:0000313|EMBL:AGJ90798.1, ECO:0000313|Proteomes:UP000012984};
RN [1] {ECO:0000313|EMBL:AGJ90798.1, ECO:0000313|Proteomes:UP000012984}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Mput9231 {ECO:0000313|EMBL:AGJ90798.1};
RX PubMed=23766410;
RA Dupuy V., Sirand-Pugnet P., Baranowski E., Barre A., Breton M., Couture C.,
RA Dordet-Frisoni E., Gaurivaud P., Jacob D., Lemaitre C., Manso-Silvan L.,
RA Nikolski M., Nouvel L.X., Poumarat F., Tardy F., Thebault P., Theil S.,
RA Citti C., Blanchard A., Thiaucourt F.;
RT "Complete Genome Sequence of Mycoplasma putrefaciens Strain 9231, One of
RT the Agents of Contagious Agalactia in Goats.";
RL Genome Announc. 1:e00354-13(2013).
CC -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via salvage
CC pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-
CC thioadenosine (hydrolase route): step 1/2.
CC {ECO:0000256|ARBA:ARBA00004945}.
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DR EMBL; CP004357; AGJ90798.1; -; Genomic_DNA.
DR RefSeq; WP_015587401.1; NC_021083.1.
DR AlphaFoldDB; M9W9W9; -.
DR KEGG; mput:MPUT9231_3840; -.
DR PATRIC; fig|1292033.3.peg.372; -.
DR eggNOG; COG0775; Bacteria.
DR HOGENOM; CLU_031248_2_2_14; -.
DR OrthoDB; 9792278at2; -.
DR UniPathway; UPA00904; UER00871.
DR Proteomes; UP000012984; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008782; F:adenosylhomocysteine nucleosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0008930; F:methylthioadenosine nucleosidase activity; IEA:InterPro.
DR GO; GO:0019509; P:L-methionine salvage from methylthioadenosine; IEA:UniProtKB-UniPathway.
DR GO; GO:0009164; P:nucleoside catabolic process; IEA:InterPro.
DR CDD; cd09008; MTAN; 1.
DR Gene3D; 3.40.50.1580; Nucleoside phosphorylase domain; 1.
DR InterPro; IPR010049; MTA_SAH_Nsdase.
DR InterPro; IPR000845; Nucleoside_phosphorylase_d.
DR InterPro; IPR035994; Nucleoside_phosphorylase_sf.
DR NCBIfam; TIGR01704; MTA_SAH-Nsdase; 1.
DR PANTHER; PTHR46832; 5'-METHYLTHIOADENOSINE/S-ADENOSYLHOMOCYSTEINE NUCLEOSIDASE; 1.
DR PANTHER; PTHR46832:SF1; 5'-METHYLTHIOADENOSINE_S-ADENOSYLHOMOCYSTEINE NUCLEOSIDASE; 1.
DR Pfam; PF01048; PNP_UDP_1; 1.
DR SUPFAM; SSF53167; Purine and uridine phosphorylases; 1.
PE 4: Predicted;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Methionine biosynthesis {ECO:0000256|ARBA:ARBA00023167};
KW Reference proteome {ECO:0000313|Proteomes:UP000012984};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 41..61
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 36..222
FT /note="Nucleoside phosphorylase"
FT /evidence="ECO:0000259|Pfam:PF01048"
SQ SEQUENCE 224 AA; 25562 MW; 00A353C59151CE97 CRC64;
MQNKKLIISA MYQELEQAIV TWSAELIEDN SIVKVYQAKN ILFAITGIGL VNASIALSYL
LSKYHIDTIL NIGTCGSLNQ NLKQQDIVIV KNAWYSAADA TAFNYSYGQI PKMTKFYQTD
KDLNKSIENK LKNFKYVNIA SADIFINNKQ QIDLFINKLE QIIDVVDMEC TSFLQTAYLF
NKKITSIKVI SDVLFSEEKN SLQFNEFINH ASKIISQIIL KLFN
//
