ID M9XAJ5_MEIRD Unreviewed; 598 AA.
AC M9XAJ5;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 24-JAN-2024, entry version 48.
DE RecName: Full=Ribonuclease Y {ECO:0000256|HAMAP-Rule:MF_00335};
DE Short=RNase Y {ECO:0000256|HAMAP-Rule:MF_00335};
DE EC=3.1.-.- {ECO:0000256|HAMAP-Rule:MF_00335};
GN Name=rny {ECO:0000256|HAMAP-Rule:MF_00335};
GN ORFNames=K649_03360 {ECO:0000313|EMBL:AGK03974.1};
OS Meiothermus ruber (strain ATCC 35948 / DSM 1279 / VKM B-1258 / 21) (Thermus
OS ruber).
OC Bacteria; Deinococcota; Deinococci; Thermales; Thermaceae; Meiothermus.
OX NCBI_TaxID=504728 {ECO:0000313|EMBL:AGK03974.1, ECO:0000313|Proteomes:UP000013026};
RN [1] {ECO:0000313|EMBL:AGK03974.1, ECO:0000313|Proteomes:UP000013026}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35948 / DSM 1279 / VKM B-1258 / 21
RC {ECO:0000313|Proteomes:UP000013026};
RA Chin J., Alexander D.H., Marks P., Korlach J., Clum A., Copeland A.;
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Endoribonuclease that initiates mRNA decay.
CC {ECO:0000256|HAMAP-Rule:MF_00335}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-Rule:MF_00335};
CC Single-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_00335}.
CC -!- SIMILARITY: Belongs to the RNase Y family. {ECO:0000256|HAMAP-
CC Rule:MF_00335}.
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DR EMBL; CP005385; AGK03974.1; -; Genomic_DNA.
DR AlphaFoldDB; M9XAJ5; -.
DR STRING; 504728.K649_03360; -.
DR KEGG; mre:K649_03360; -.
DR PATRIC; fig|504728.9.peg.696; -.
DR eggNOG; COG1418; Bacteria.
DR eggNOG; COG4372; Bacteria.
DR Proteomes; UP000013026; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004521; F:RNA endonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006402; P:mRNA catabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd00077; HDc; 1.
DR CDD; cd22431; KH-I_RNaseY; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR Gene3D; 3.30.1370.10; K Homology domain, type 1; 1.
DR HAMAP; MF_00335; RNase_Y; 1.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR006675; HDIG_dom.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR InterPro; IPR017705; Ribonuclease_Y.
DR InterPro; IPR022711; RNase_Y_N.
DR NCBIfam; TIGR00277; HDIG; 1.
DR NCBIfam; TIGR03319; RNase_Y; 1.
DR PANTHER; PTHR12826; RIBONUCLEASE Y; 1.
DR PANTHER; PTHR12826:SF15; RIBONUCLEASE Y; 1.
DR Pfam; PF01966; HD; 1.
DR Pfam; PF00013; KH_1; 1.
DR Pfam; PF12072; RNase_Y_N; 1.
DR SMART; SM00471; HDc; 1.
DR SMART; SM00322; KH; 1.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR PROSITE; PS51831; HD; 1.
DR PROSITE; PS50084; KH_TYPE_1; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|HAMAP-Rule:MF_00335};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759, ECO:0000256|HAMAP-
KW Rule:MF_00335};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00335};
KW Membrane {ECO:0000256|HAMAP-Rule:MF_00335};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|HAMAP-Rule:MF_00335};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|HAMAP-
KW Rule:MF_00335}; Transmembrane {ECO:0000256|HAMAP-Rule:MF_00335};
KW Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_00335}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00335"
FT DOMAIN 414..507
FT /note="HD"
FT /evidence="ECO:0000259|PROSITE:PS51831"
FT COILED 32..274
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 598 AA; 66882 MW; 9EE2EAC140AC0159 CRC64;
MQPLEVPMAF TPLDLILTLI VVVLAVVVVV LLQRSNRQTE VSKSELEAAR REAQQTLEAA
RRQAQTALEQ AQNQAQALLE AARAEAQSLR QNAQTEIQNL RQNAHVELER LRQQGEERLR
QQLREERERL QASLQAEREA LMSERASIQA ERERLQADLQ ASRAEREELK RETERLARRG
EQLDARAAKL DEQEEKLDAL EKTLEARQAE LAQRERQIDL KLQEVAGMSR EEAQNLLLSR
LDAELEEEKA LRVKANLERI RLEVKREAQK LLAQAAQRQA SETAAALAVS VVPIPSDAMK
GRIIGREGRN IRTFEALTGV DLIIDDTPEA VLLSSFNPMR REIARMALEQ LVADGRIHPS
RIEEVVEKAK NEMKTFIYER GEEAALEAGV VGLKPGLVQL LGRLHFRSSY GQNVLKHSVQ
VAHLTGIMAA ELGLDAALGR RAGLLHDLGK SVDREIEGTH VEIGVTLATR FGEPKEVIDA
IAHHHDPENG ETLYSVLAAA ADAISAARPG ARRESLEEYI QRLEQLERIA LSFPGVDNAF
AVQAGREVRV IVKPDRISDA KATLLAREIA GRIERDMNYP GQVQVTVVRE SRAVEYAK
//
