ID M9Z6K4_GOSRA Unreviewed; 512 AA.
AC M9Z6K4;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE RecName: Full=3-ketoacyl-CoA synthase {ECO:0000256|PIRNR:PIRNR036417};
DE EC=2.3.1.- {ECO:0000256|PIRNR:PIRNR036417};
GN Name=KCS19 {ECO:0000313|EMBL:AGK29992.1};
GN ORFNames=B456_004G278700 {ECO:0000313|EMBL:KJB27112.1}, Gorai_015719
GN {ECO:0000313|EMBL:MBA0584925.1};
OS Gossypium raimondii (New World cotton).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=29730 {ECO:0000313|EMBL:AGK29992.1};
RN [1] {ECO:0000313|EMBL:KJB27112.1, ECO:0000313|Proteomes:UP000032304}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23257886; DOI=10.1038/nature11798;
RA Paterson A.H., Wendel J.F., Gundlach H., Guo H., Jenkins J., Jin D.,
RA Llewellyn D., Showmaker K.C., Shu S., Udall J., Yoo M.J., Byers R.,
RA Chen W., Doron-Faigenboim A., Duke M.V., Gong L., Grimwood J., Grover C.,
RA Grupp K., Hu G., Lee T.H., Li J., Lin L., Liu T., Marler B.S., Page J.T.,
RA Roberts A.W., Romanel E., Sanders W.S., Szadkowski E., Tan X., Tang H.,
RA Xu C., Wang J., Wang Z., Zhang D., Zhang L., Ashrafi H., Bedon F.,
RA Bowers J.E., Brubaker C.L., Chee P.W., Das S., Gingle A.R., Haigler C.H.,
RA Harker D., Hoffmann L.V., Hovav R., Jones D.C., Lemke C., Mansoor S.,
RA ur Rahman M., Rainville L.N., Rambani A., Reddy U.K., Rong J.K.,
RA Saranga Y., Scheffler B.E., Scheffler J.A., Stelly D.M., Triplett B.A.,
RA Van Deynze A., Vaslin M.F., Waghmare V.N., Walford S.A., Wright R.J.,
RA Zaki E.A., Zhang T., Dennis E.S., Mayer K.F., Peterson D.G., Rokhsar D.S.,
RA Wang X., Schmutz J.;
RT "Repeated polyploidization of Gossypium genomes and the evolution of
RT spinnable cotton fibres.";
RL Nature 492:423-427(2012).
RN [2] {ECO:0000313|EMBL:AGK29992.1}
RP NUCLEOTIDE SEQUENCE.
RA Xiao G.-H., Li Q., Zhu Y.-X.;
RT "Functional analysis and molecular cloning of Gossypium raimondii KCS
RT genes.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:MBA0584925.1, ECO:0000313|Proteomes:UP000593578}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=8 {ECO:0000313|EMBL:MBA0584925.1};
RC TISSUE=Leaf {ECO:0000313|EMBL:MBA0584925.1};
RX PubMed=30476109;
RA Grover C.E., Arick M.A. 2nd, Thrash A., Conover J.L., Sanders W.S.,
RA Peterson D.G., Frelichowski J.E., Scheffler J.A., Scheffler B.E.,
RA Wendel J.F.;
RT "Insights into the Evolution of the New World Diploid Cottons (Gossypium,
RT Subgenus Houzingenia) Based on Genome Sequencing.";
RL Genome Biol. Evol. 11:53-71(2019).
RN [4] {ECO:0000313|EMBL:MBA0584925.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=8 {ECO:0000313|EMBL:MBA0584925.1};
RC TISSUE=Leaf {ECO:0000313|EMBL:MBA0584925.1};
RA Grover C.E., Arick M.A. II, Thrash A., Conover J.L., Sanders W.S.,
RA Peterson D.G., Scheffler J.A., Scheffler B.E., Wendel J.F.;
RL Submitted (APR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a very-long-chain acyl-CoA + H(+) + malonyl-CoA = a very-long-
CC chain 3-oxoacyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:32727,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57384, ChEBI:CHEBI:90725, ChEBI:CHEBI:90736;
CC EC=2.3.1.199; Evidence={ECO:0000256|ARBA:ARBA00001906};
CC -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005194, ECO:0000256|PIRNR:PIRNR036417}.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC synthases family. {ECO:0000256|ARBA:ARBA00005531,
CC ECO:0000256|PIRNR:PIRNR036417}.
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DR EMBL; KC160458; AGK29992.1; -; Genomic_DNA.
DR EMBL; CM001743; KJB27112.1; -; Genomic_DNA.
DR EMBL; JABEZZ010000004; MBA0584925.1; -; Genomic_DNA.
DR RefSeq; XP_012477167.1; XM_012621713.1.
DR AlphaFoldDB; M9Z6K4; -.
DR STRING; 29730.M9Z6K4; -.
DR EnsemblPlants; KJB27112; KJB27112; B456_004G278700.
DR GeneID; 105792878; -.
DR Gramene; KJB27112; KJB27112; B456_004G278700.
DR KEGG; gra:105792878; -.
DR eggNOG; ENOG502QPKZ; Eukaryota.
DR OMA; DKARICT; -.
DR OrthoDB; 930987at2759; -.
DR UniPathway; UPA00094; -.
DR Proteomes; UP000032304; Chromosome 4.
DR Proteomes; UP000593578; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0009922; F:fatty acid elongase activity; IEA:UniProtKB-EC.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00831; CHS_like; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR InterPro; IPR012392; 3-ktacl-CoA_syn.
DR InterPro; IPR013747; ACP_syn_III_C.
DR InterPro; IPR013601; FAE1_typ3_polyketide_synth.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR31561; 3-KETOACYL-COA SYNTHASE; 1.
DR PANTHER; PTHR31561:SF103; 3-KETOACYL-COA SYNTHASE 11; 1.
DR Pfam; PF08541; ACP_syn_III_C; 1.
DR Pfam; PF08392; FAE1_CUT1_RppA; 1.
DR PIRSF; PIRSF036417; 3-ktacl-CoA_syn; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|PIRNR:PIRNR036417};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000032304};
KW Transferase {ECO:0000256|PIRNR:PIRNR036417};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 34..56
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 76..97
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 95..384
FT /note="FAE"
FT /evidence="ECO:0000259|Pfam:PF08392"
FT DOMAIN 401..481
FT /note="Beta-ketoacyl-[acyl-carrier-protein] synthase III C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF08541"
SQ SEQUENCE 512 AA; 57642 MW; A76B91B6C87BC910 CRC64;
MAETKPENQQ PLLRSSTRNL PDFKKSVKLK YVKLGYHYVV THGMYLFLSP LVVVIAVQLS
TFSIQDLHDL WEHLQYNLIS VIICSMLLVF LSTLYFLTRP RPVYLVNFSC YKPDKARICT
KKMFVDQSQM AGTFTEENLL FQCKILERSG LGESTYLPEA VLNIPPNPSM KEARKEAEAV
MYGAIDELLA KTLVNPKDIG ILVVNCSLFN PTPSLSAMVI NHYKLRGNIQ SYNLGGMGCS
AGLISIDLAK NLLQVHPNTY ALVISMENIT LNWYFGNDRS KLVSNCLFRM GGAAILLSNK
SSDRRRSKYR LVHTVRTHKG ADDKCFGCVT QEEDSTGQIG VTLSKDLMGV AGDALKTNIT
TLGPLVLPMS EQLLFFATLV GKKLFKMKIK PYIPDFKLAF EHFCIHAGGR AVLDELEKNL
QLSEWHMEPS RMTLYRFGNT SSSSLWYELA YSEAKGRIKK GDRTWQIAFG SGFKCNSAVW
KALGTINPAK EKNPWMDEIH NFPVNVPRVS TI
//
