ID MACP2_ARATH Reviewed; 606 AA.
AC Q9STW5; B3DN86; F4JQ79;
DT 22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 24-JAN-2024, entry version 117.
DE RecName: Full=MACPF domain-containing protein At4g24290;
GN OrderedLocusNames=At4g24290; ORFNames=T22A6.120;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=14993207; DOI=10.1101/gr.1515604;
RA Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M.,
RA Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M.,
RA Weissenbach J., Salanoubat M.;
RT "Whole genome sequence comparisons and 'full-length' cDNA sequences: a
RT combined approach to evaluate and improve Arabidopsis genome annotation.";
RL Genome Res. 14:406-413(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RA de los Reyes C., Quan R., Chen H., Bautista V., Kim C.J., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY.
RX PubMed=16900325; DOI=10.1007/s11103-006-9001-6;
RA Noutoshi Y., Kuromori T., Wada T., Hirayama T., Kamiya A., Imura Y.,
RA Yasuda M., Nakashita H., Shirasu K., Shinozaki K.;
RT "Loss of Necrotic Spotted Lesions 1 associates with cell death and defense
RT responses in Arabidopsis thaliana.";
RL Plant Mol. Biol. 62:29-42(2006).
CC -!- FUNCTION: Negatively controls the salicylic acid (SA)-mediated pathway
CC of programmed cell death in plant immunity. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9STW5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9STW5-2; Sequence=VSP_042282, VSP_042283;
CC -!- MISCELLANEOUS: [Isoform 2]: May be due to an intron retention.
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the complement C6/C7/C8/C9 (TC 1.C.39) family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BX826919; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305};
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DR EMBL; AL078637; CAB45064.1; -; Genomic_DNA.
DR EMBL; AL161561; CAB79339.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE84885.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE84886.1; -; Genomic_DNA.
DR EMBL; CP002687; ANM66407.1; -; Genomic_DNA.
DR EMBL; BX826919; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BT032874; ACD89064.1; -; mRNA.
DR PIR; T09892; T09892.
DR RefSeq; NP_001328303.1; NM_001341662.1. [Q9STW5-1]
DR RefSeq; NP_567698.1; NM_118562.2. [Q9STW5-2]
DR RefSeq; NP_849433.1; NM_179102.5. [Q9STW5-1]
DR AlphaFoldDB; Q9STW5; -.
DR STRING; 3702.Q9STW5; -.
DR iPTMnet; Q9STW5; -.
DR SwissPalm; Q9STW5; -.
DR PaxDb; 3702-AT4G24290-2; -.
DR ProteomicsDB; 238233; -. [Q9STW5-1]
DR EnsemblPlants; AT4G24290.1; AT4G24290.1; AT4G24290. [Q9STW5-2]
DR EnsemblPlants; AT4G24290.2; AT4G24290.2; AT4G24290. [Q9STW5-1]
DR EnsemblPlants; AT4G24290.3; AT4G24290.3; AT4G24290. [Q9STW5-1]
DR GeneID; 828532; -.
DR Gramene; AT4G24290.1; AT4G24290.1; AT4G24290. [Q9STW5-2]
DR Gramene; AT4G24290.2; AT4G24290.2; AT4G24290. [Q9STW5-1]
DR Gramene; AT4G24290.3; AT4G24290.3; AT4G24290. [Q9STW5-1]
DR KEGG; ath:AT4G24290; -.
DR Araport; AT4G24290; -.
DR TAIR; AT4G24290; -.
DR eggNOG; ENOG502QPZ4; Eukaryota.
DR HOGENOM; CLU_034245_1_0_1; -.
DR InParanoid; Q9STW5; -.
DR OMA; EDTVCIC; -.
DR OrthoDB; 458620at2759; -.
DR PhylomeDB; Q9STW5; -.
DR PRO; PR:Q9STW5; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q9STW5; baseline and differential.
DR Genevisible; Q9STW5; AT.
DR GO; GO:0005886; C:plasma membrane; HDA:TAIR.
DR GO; GO:0009626; P:plant-type hypersensitive response; IEA:UniProtKB-KW.
DR GO; GO:2000031; P:regulation of salicylic acid mediated signaling pathway; IEA:InterPro.
DR InterPro; IPR044663; CAD1/NSL1-like.
DR InterPro; IPR020864; MACPF.
DR PANTHER; PTHR33199; MACPF DOMAIN-CONTAINING PROTEIN CAD1; 1.
DR PANTHER; PTHR33199:SF1; OS01G0958700 PROTEIN; 1.
DR Pfam; PF01823; MACPF; 1.
DR SMART; SM00457; MACPF; 1.
DR PROSITE; PS51412; MACPF_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Hypersensitive response; Immunity; Innate immunity;
KW Plant defense; Reference proteome.
FT CHAIN 1..606
FT /note="MACPF domain-containing protein At4g24290"
FT /id="PRO_0000415542"
FT DOMAIN 1..332
FT /note="MACPF"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00745"
FT VAR_SEQ 321..350
FT /note="YKPPIEELHQFLEFQLPRQWAPVFSELPLG -> CKPINHLRFVHFFLELFF
FT ILVVSFTFRLEV (in isoform 2)"
FT /evidence="ECO:0000303|Ref.4"
FT /id="VSP_042282"
FT VAR_SEQ 351..606
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.4"
FT /id="VSP_042283"
FT CONFLICT 280
FT /note="W -> R (in Ref. 4; ACD89064)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 606 AA; 67934 MW; EEE60EB366FEAE6C CRC64;
MALRLPASKA AEVAIGSIGC GYDLAIDLRL KYCKGGSKDS RLLDIKEGDD NCEIVLPGGI
SIPNVSKSIK CDKGERMRFR SDILPFQQMA EQFNQELSLA GKIPSGLFNA MFEFSSCWQK
DAAYTKNLAF DGVFISLYSV ALDKSQVLLR EHVKQAVPST WDPAALARFI DIYGTHIIVS
VKMGGKDVIY AKQQHSSKLQ PEDLQKRLKE VADKRFVEAS VVHNTGSERV QASSKVETKE
QRLRFADTSS LGSYANKEDY VFMCKRRGGN DNRNLMHNEW LQTVQMEPDV ISMSFIPITS
LLNGVPGSGF LSHAINLYLR YKPPIEELHQ FLEFQLPRQW APVFSELPLG PQRKQQSCAS
LQFSFFGPKL YVNTTPVDVG KRPITGMRLY LEGRRSNRLA IHLQHLSSLP KIYQLEDDLN
RSIRQESHDR RYYEKVNWKN YSHVCTEPVE SDDDLSVVTG AQLHVESHGF KNVLFLRLCF
SRVVGATLVK NSEWDEAVGF APKSGLISTL ISHHFTAAQK PPPRPADVNI NSAIYPGGPP
VPTQAPKLLK FVDTSEMTRG PQESPGYWVV SGARLLVEKG KISLKVKYSL FTPILGDEVI
EEAYEG
//
