ID MALD2_XENTR Reviewed; 568 AA.
AC Q0IHQ3; Q28D82;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2006, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=MARVEL domain-containing protein 2;
GN Name=marveld2; Synonyms=mrvldc2; ORFNames=TGas093b21.1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Gastrula;
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=N6; TISSUE=Skin;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May play a role in the formation of the epithelial barrier.
CC {ECO:0000250|UniProtKB:Q3UZP0}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q3UZP0};
CC Multi-pass membrane protein {ECO:0000250|UniProtKB:Q3UZP0}. Cell
CC junction, tight junction {ECO:0000250|UniProtKB:Q3UZP0}. Note=Found at
CC tricellular contacts. {ECO:0000250|UniProtKB:Q3UZP0}.
CC -!- SIMILARITY: Belongs to the ELL/occludin family. {ECO:0000255|PROSITE-
CC ProRule:PRU01324}.
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DR EMBL; CR855651; CAJ83822.1; -; mRNA.
DR EMBL; BC123026; AAI23027.1; -; mRNA.
DR RefSeq; NP_001017292.1; NM_001017292.2.
DR AlphaFoldDB; Q0IHQ3; -.
DR SMR; Q0IHQ3; -.
DR STRING; 8364.ENSXETP00000043692; -.
DR PaxDb; 8364-ENSXETP00000039416; -.
DR DNASU; 550046; -.
DR GeneID; 550046; -.
DR KEGG; xtr:550046; -.
DR AGR; Xenbase:XB-GENE-5839559; -.
DR CTD; 153562; -.
DR Xenbase; XB-GENE-5839559; marveld2.
DR eggNOG; KOG4796; Eukaryota.
DR InParanoid; Q0IHQ3; -.
DR OrthoDB; 2910197at2759; -.
DR Proteomes; UP000008143; Chromosome 1.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070160; C:tight junction; ISS:UniProtKB.
DR Gene3D; 6.10.140.340; -; 1.
DR InterPro; IPR031176; ELL/occludin.
DR InterPro; IPR008253; Marvel.
DR InterPro; IPR010844; Occludin_ELL.
DR PANTHER; PTHR23288:SF3; MARVEL DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR23288; OCCLUDIN AND RNA POLYMERASE II ELONGATION FACTOR ELL; 1.
DR Pfam; PF01284; MARVEL; 1.
DR Pfam; PF07303; Occludin_ELL; 1.
DR SUPFAM; SSF144292; occludin/ELL-like; 1.
DR PROSITE; PS51225; MARVEL; 1.
DR PROSITE; PS51980; OCEL; 1.
PE 2: Evidence at transcript level;
KW Cell junction; Cell membrane; Coiled coil; Membrane; Reference proteome;
KW Tight junction; Transmembrane; Transmembrane helix.
FT CHAIN 1..568
FT /note="MARVEL domain-containing protein 2"
FT /id="PRO_0000271528"
FT TOPO_DOM 1..211
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 212..232
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 233..266
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 267..287
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 288..303
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 304..324
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 325..354
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 355..375
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 376..568
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 205..379
FT /note="MARVEL"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00581"
FT DOMAIN 451..562
FT /note="OCEL"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01324"
FT REGION 1..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 116..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 462..559
FT /evidence="ECO:0000255"
FT COMPBIAS 1..17
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..46
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..64
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 136
FT /note="G -> E (in Ref. 1; CAJ83822)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 568 AA; 64880 MW; 545EECDD8618F40B CRC64;
MSGGGSSSGP RSKDRNLNGR SAQYDEVPAD PRHPETNLET LHDRDLALSA DPLPPPPLPL
HPPFGAEFYP SDSEEPVTTL ELRPVRRFIP DSWKNIFKGK KENPWENPMT EINYTSGGVP
CSPPRSPSLP ASEPHGKNLA GDSKTVASSY RDPYGGSGGS YNSRREEEAM LPHDPYGSLG
RQTQTVKTYS ERVEEYNMRY AYMKSWAGLL RILCIVELLL GAAVFACVTA YIHKDNEWYN
MFGYSQPYGY TASMQGGYYY SGPKTPFVLV VAGLAWIVTI ILLVLGMSMY YRTILLDSTW
WPLTEFGINI SLFILYMAGA IVYVNDTNRG GLCYYQLFNT PVNASFCRVE GGQTAAIIFL
FVSMLMYFIS AMVSLKLWRH ESARKRREFL GQEMNPNQIS PPKVMREVAL GNGHMIDVPD
QQRDMRKVEM KPELLSGYIP AGHIPKPIVM PDYVAKYQAI KAEDERERYK AVFNDQFAEY
KELHAEVQAV MKKFSELDAV MQKLPRNPEN QHEYERIAKV LQEYQKKKNE PTFLEKKERC
EYLKNKLSHI KQRIQEYDKV MDWNDGYN
//
