ID MDTJ_ENT38 Reviewed; 120 AA.
AC A4WA57;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 29-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 91.
DE RecName: Full=Spermidine export protein MdtJ {ECO:0000255|HAMAP-Rule:MF_01598};
GN Name=mdtJ {ECO:0000255|HAMAP-Rule:MF_01598}; OrderedLocusNames=Ent638_1911;
OS Enterobacter sp. (strain 638).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Enterobacter.
OX NCBI_TaxID=399742;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=638;
RX PubMed=20485560; DOI=10.1371/journal.pgen.1000943;
RA Taghavi S., van der Lelie D., Hoffman A., Zhang Y.B., Walla M.D.,
RA Vangronsveld J., Newman L., Monchy S.;
RT "Genome sequence of the plant growth promoting endophytic bacterium
RT Enterobacter sp. 638.";
RL PLoS Genet. 6:E1000943-E1000943(2010).
CC -!- FUNCTION: Catalyzes the excretion of spermidine. {ECO:0000255|HAMAP-
CC Rule:MF_01598}.
CC -!- SUBUNIT: Forms a complex with MdtI. {ECO:0000255|HAMAP-Rule:MF_01598}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01598}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01598}.
CC -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. MdtJ
CC subfamily. {ECO:0000255|HAMAP-Rule:MF_01598}.
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DR EMBL; CP000653; ABP60587.1; -; Genomic_DNA.
DR RefSeq; WP_012017302.1; NC_009436.1.
DR AlphaFoldDB; A4WA57; -.
DR SMR; A4WA57; -.
DR STRING; 399742.Ent638_1911; -.
DR KEGG; ent:Ent638_1911; -.
DR eggNOG; COG2076; Bacteria.
DR HOGENOM; CLU_133067_0_0_6; -.
DR OrthoDB; 9808638at2; -.
DR Proteomes; UP000000230; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015606; F:spermidine transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0042221; P:response to chemical; IEA:UniProt.
DR Gene3D; 1.10.3730.20; -; 1.
DR HAMAP; MF_01598; MdtJ; 1.
DR InterPro; IPR000390; Small_drug/metabolite_transptr.
DR InterPro; IPR045324; Small_multidrug_res.
DR InterPro; IPR023740; Spermidine_export_MdtJ.
DR PANTHER; PTHR30561; SMR FAMILY PROTON-DEPENDENT DRUG EFFLUX TRANSPORTER SUGE; 1.
DR PANTHER; PTHR30561:SF2; SPERMIDINE EXPORT PROTEIN MDTJ; 1.
DR Pfam; PF00893; Multi_Drug_Res; 1.
DR SUPFAM; SSF103481; Multidrug resistance efflux transporter EmrE; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..120
FT /note="Spermidine export protein MdtJ"
FT /id="PRO_0000331165"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01598"
FT TRANSMEM 31..51
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01598"
FT TRANSMEM 54..74
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01598"
FT TRANSMEM 81..101
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01598"
SQ SEQUENCE 120 AA; 13069 MW; 0F07D6023688D630 CRC64;
MFYWILLALA IVAEITGTLS MKWASISDDN TGFILMLVMI SLSYIFLSFA VKKIALGVAY
ALWEGIGILL ITLFSVMLFD EALSTMKIAG LATLVVGIVL IKSGTRKPTK QPKEQAHATV
//
