ID MDTP_ECOLI Reviewed; 488 AA.
AC P32714; Q2M6M4;
DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT 15-JUL-1998, sequence version 2.
DT 27-MAR-2024, entry version 163.
DE RecName: Full=Multidrug resistance outer membrane protein MdtP;
DE Flags: Precursor;
GN Name=mdtP; Synonyms=yjcP; OrderedLocusNames=b4080, JW4041;
OS Escherichia coli (strain K12).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=8265357; DOI=10.1093/nar/21.23.5408;
RA Blattner F.R., Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L.;
RT "Analysis of the Escherichia coli genome. IV. DNA sequence of the region
RT from 89.2 to 92.8 minutes.";
RL Nucleic Acids Res. 21:5408-5417(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND SEQUENCE REVISION TO
RP 170.
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP FUNCTION.
RX PubMed=11257026; DOI=10.1128/aac.45.4.1126-1136.2001;
RA Sulavik M.C., Houseweart C., Cramer C., Jiwani N., Murgolo N., Greene J.,
RA DiDomenico B., Shaw K.J., Miller G.H., Hare R., Shimer G.;
RT "Antibiotic susceptibility profiles of Escherichia coli strains lacking
RT multidrug efflux pump genes.";
RL Antimicrob. Agents Chemother. 45:1126-1136(2001).
CC -!- FUNCTION: Could be involved in resistance to puromycin, acriflavine and
CC tetraphenylarsonium chloride. {ECO:0000269|PubMed:11257026}.
CC -!- SUBUNIT: Could be part of a tripartite efflux system composed of MdtN,
CC MdtO and MdtP.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000305}; Lipid-anchor
CC {ECO:0000255|PROSITE-ProRule:PRU00303}.
CC -!- SIMILARITY: Belongs to the outer membrane factor (OMF) (TC 1.B.17)
CC family. {ECO:0000305}.
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DR EMBL; U00006; AAC43174.1; -; Genomic_DNA.
DR EMBL; U00096; AAD13463.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE78082.1; -; Genomic_DNA.
DR PIR; G65216; G65216.
DR RefSeq; NP_418504.1; NC_000913.3.
DR RefSeq; WP_000610601.1; NZ_SSZK01000016.1.
DR AlphaFoldDB; P32714; -.
DR SMR; P32714; -.
DR BioGRID; 4262951; 161.
DR ComplexPortal; CPX-6021; SdsRQP multidrug transport complex.
DR IntAct; P32714; 3.
DR STRING; 511145.b4080; -.
DR TCDB; 1.B.17.3.9; the outer membrane factor (omf) family.
DR PaxDb; 511145-b4080; -.
DR EnsemblBacteria; AAD13463; AAD13463; b4080.
DR GeneID; 948583; -.
DR KEGG; ecj:JW4041; -.
DR KEGG; eco:b4080; -.
DR PATRIC; fig|1411691.4.peg.2621; -.
DR EchoBASE; EB1895; -.
DR eggNOG; COG1538; Bacteria.
DR HOGENOM; CLU_012817_6_3_6; -.
DR InParanoid; P32714; -.
DR OMA; TRALEHM; -.
DR OrthoDB; 9770517at2; -.
DR PhylomeDB; P32714; -.
DR BioCyc; EcoCyc:EG11952-MONOMER; -.
DR BioCyc; MetaCyc:EG11952-MONOMER; -.
DR PRO; PR:P32714; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0009279; C:cell outer membrane; ISA:EcoCyc.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:1990351; C:transporter complex; NAS:ComplexPortal.
DR GO; GO:0015562; F:efflux transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0046677; P:response to antibiotic; IMP:EcoCyc.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.20.1600.10; Outer membrane efflux proteins (OEP); 1.
DR Gene3D; 2.20.200.10; Outer membrane efflux proteins (OEP); 1.
DR InterPro; IPR003423; OMP_efflux.
DR InterPro; IPR010131; RND_efflux_OM_lipoprot_NodT.
DR NCBIfam; TIGR01845; outer_NodT; 1.
DR PANTHER; PTHR30203:SF20; MULTIDRUG RESISTANCE OUTER MEMBRANE PROTEIN MDTP-RELATED; 1.
DR PANTHER; PTHR30203; OUTER MEMBRANE CATION EFFLUX PROTEIN; 1.
DR Pfam; PF02321; OEP; 2.
DR SUPFAM; SSF56954; Outer membrane efflux proteins (OEP); 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Antibiotic resistance; Cell outer membrane; Lipoprotein; Membrane;
KW Palmitate; Reference proteome; Signal; Transmembrane;
KW Transmembrane beta strand.
FT SIGNAL 1..23
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT CHAIN 24..488
FT /note="Multidrug resistance outer membrane protein MdtP"
FT /id="PRO_0000031009"
FT LIPID 24
FT /note="N-palmitoyl cysteine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT LIPID 24
FT /note="S-diacylglycerol cysteine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT CONFLICT 170
FT /note="G -> A (in Ref. 1; AAC43174)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 488 AA; 53453 MW; C281EEDDD8595ADA CRC64;
MINRQLSRLL LCSILGSTTL ISGCALVRKD SAPHQQLKPE QIKLADDIHL ASSGWPQAQW
WKQLNDPQLD ALIQRTLSGS HTLAEAKLRE EKAQSQADLL DAGSQLQVAA LGMLNRQRVS
ANGFLSPYSM DAPALGMDGP YYTEATVGLF AGLDLDLWGV HRSAVAAAIG AHNAALAETA
AVELSLATGV AQLYYSMQAS YQMLDLLEQT HDVIDYAVKA HQSKVAHGLE AQVPFHGARA
QILAVDKQIV AVKGQITETR ESLRALIGAG ASDMPEIRPV ALPQVQTGIP ATLSYELLAR
RPDLQAMRWY VQASLDQVDS ARALFYPSFD IKAFFGLDSI HLHTLFKKTS RQFNFIPGLK
LPLFDGGRLN ANLEGTRAAS NMMIERYNQS VLNAVRDVAV NGTRLQTLND EREMQAERVE
ATRFTQRAAE AAYQRGLTSR LQATEARLPV LAEEMSLLML DSRRVIQSIQ LMKSLGGGYQ
AGPVVEKK
//
