ID MECA_ENTFA Reviewed; 220 AA.
AC Q830U4;
DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 85.
DE RecName: Full=Adapter protein MecA {ECO:0000255|HAMAP-Rule:MF_01124};
GN Name=mecA {ECO:0000255|HAMAP-Rule:MF_01124}; OrderedLocusNames=EF_2677;
OS Enterococcus faecalis (strain ATCC 700802 / V583).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
OC Enterococcus.
OX NCBI_TaxID=226185;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700802 / V583;
RX PubMed=12663927; DOI=10.1126/science.1080613;
RA Paulsen I.T., Banerjei L., Myers G.S.A., Nelson K.E., Seshadri R.,
RA Read T.D., Fouts D.E., Eisen J.A., Gill S.R., Heidelberg J.F., Tettelin H.,
RA Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C.,
RA DeBoy R.T., Durkin S.A., Kolonay J.F., Madupu R., Nelson W.C.,
RA Vamathevan J.J., Tran B., Upton J., Hansen T., Shetty J., Khouri H.M.,
RA Utterback T.R., Radune D., Ketchum K.A., Dougherty B.A., Fraser C.M.;
RT "Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus
RT faecalis.";
RL Science 299:2071-2074(2003).
CC -!- FUNCTION: Enables the recognition and targeting of unfolded and
CC aggregated proteins to the ClpC protease or to other proteins involved
CC in proteolysis. {ECO:0000255|HAMAP-Rule:MF_01124}.
CC -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01124}.
CC -!- DOMAIN: The N-terminal domain probably binds unfolded/aggregated
CC proteins; the C-terminal domain interacts with ClpC.
CC -!- SIMILARITY: Belongs to the MecA family. {ECO:0000255|HAMAP-
CC Rule:MF_01124}.
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DR EMBL; AE016830; AAO82382.1; -; Genomic_DNA.
DR RefSeq; NP_816312.1; NC_004668.1.
DR RefSeq; WP_002356478.1; NZ_KE136528.1.
DR AlphaFoldDB; Q830U4; -.
DR SMR; Q830U4; -.
DR STRING; 226185.EF_2677; -.
DR EnsemblBacteria; AAO82382; AAO82382; EF_2677.
DR GeneID; 60894671; -.
DR KEGG; efa:EF2677; -.
DR PATRIC; fig|226185.45.peg.885; -.
DR eggNOG; COG4862; Bacteria.
DR HOGENOM; CLU_071496_2_0_9; -.
DR Proteomes; UP000001415; Chromosome.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.70.1950; -; 1.
DR HAMAP; MF_01124; MecA; 1.
DR InterPro; IPR038471; MecA_C_sf.
DR InterPro; IPR008681; Neg-reg_MecA.
DR PANTHER; PTHR39161; ADAPTER PROTEIN MECA; 1.
DR PANTHER; PTHR39161:SF1; ADAPTER PROTEIN MECA; 1.
DR Pfam; PF05389; MecA; 1.
DR PIRSF; PIRSF029008; MecA; 1.
PE 3: Inferred from homology;
KW Reference proteome.
FT CHAIN 1..220
FT /note="Adapter protein MecA"
FT /id="PRO_0000212269"
SQ SEQUENCE 220 AA; 25345 MW; 40AF1044BC897BD3 CRC64;
MEMEHINENT IRVLIGNEDL ADRGITFLDL LGNHKDVENF FYSILEEVDV EDEFQGSEAV
TFQVLPKNDG LELFISKNVA MDDLSSLEGL SEVNADVSEL IRKQIEADKA AADELDEMEA
TDETNRNVIF ELDNFEAMIQ LSKEVFMQSV LTNLYTYNDR YYLQVLFLTD ELEKTNVDNE
IAQILEFAHK TTVTQDTLVE YGTCIMERSA LELTRYYFND
//
