ID MFRN_DICDI Reviewed; 308 AA.
AC Q55DY8;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 27-MAR-2024, entry version 107.
DE RecName: Full=Mitoferrin;
DE AltName: Full=Mitochondrial substrate carrier family protein F;
GN Name=mcfF; ORFNames=DDB_G0269470;
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP REVIEW.
RX PubMed=17442478; DOI=10.1016/j.biochi.2007.03.004;
RA Satre M., Mattei S., Aubry L., Gaudet P., Pelosi L., Brandolin G.,
RA Klein G.;
RT "Mitochondrial carrier family: repertoire and peculiarities of the cellular
RT slime mould Dictyostelium discoideum.";
RL Biochimie 89:1058-1069(2007).
CC -!- FUNCTION: Mitochondrial solute carriers shuttle metabolites,
CC nucleotides, and cofactors through the mitochondrial inner membrane.
CC Mitochondrial iron transporter that mediates iron uptake. Probably
CC required for heme synthesis of hemoproteins and Fe-S cluster assembly
CC (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000005; EAL72085.1; -; Genomic_DNA.
DR RefSeq; XP_645993.1; XM_640901.1.
DR AlphaFoldDB; Q55DY8; -.
DR SMR; Q55DY8; -.
DR STRING; 44689.Q55DY8; -.
DR PaxDb; 44689-DDB0237598; -.
DR EnsemblProtists; EAL72085; EAL72085; DDB_G0269470.
DR GeneID; 8616939; -.
DR KEGG; ddi:DDB_G0269470; -.
DR dictyBase; DDB_G0269470; mcfF.
DR eggNOG; KOG0760; Eukaryota.
DR HOGENOM; CLU_015166_3_1_1; -.
DR InParanoid; Q55DY8; -.
DR OMA; THCTAGA; -.
DR PhylomeDB; Q55DY8; -.
DR PRO; PR:Q55DY8; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031966; C:mitochondrial membrane; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; ISS:dictyBase.
DR GO; GO:0015093; F:ferrous iron transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005381; F:iron ion transmembrane transporter activity; ISS:dictyBase.
DR GO; GO:0048250; P:iron import into the mitochondrion; ISS:dictyBase.
DR Gene3D; 1.50.40.10; Mitochondrial carrier domain; 2.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR PANTHER; PTHR45758:SF4; MITOFERRIN-1; 1.
DR PANTHER; PTHR45758; MITOFERRIN-1-RELATED; 1.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; Mitochondrial carrier; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..308
FT /note="Mitoferrin"
FT /id="PRO_0000329413"
FT TRANSMEM 13..29
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 69..89
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 111..131
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 168..184
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 213..233
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 285..302
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 14..100
FT /note="Solcar 1"
FT REPEAT 108..192
FT /note="Solcar 2"
FT REPEAT 207..305
FT /note="Solcar 3"
SQ SEQUENCE 308 AA; 33914 MW; 707CA0191358C0CA CRC64;
MGGDHGHSHG DEGGSFYVHL IAGAAAGFAE HCGMYPIDTI KTHIQAIKPG AMQTSSLQIT
KHIIQQHGIT GLFRGLTAVA AGAAPSHAVH FSIYELLKFK FIGSDEDHHP IKVGIAGAIA
TMTSEAVASP MDVVKQRLQL QITDYKGLTD CTKRIWVKEG IRGFYSGYTT TLVMNVPYNI
VYFASYESLK KIIQPWFNNK NPEERSYQLI DHLVAGGGAG MLAAAFTNPF DVVKTRLQTQ
SDFIASSTIN SAKSIKRYGG MMDAMKTIWI EEGMDGYLRG MKPRMVFHSM SSAIVWSVYE
YFKFILGE
//
